Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Guillem Paniagua-Soriano"'
Autor:
Muhammad Riaz, Yotam Raz, Maaike van Putten, Guillem Paniagua-Soriano, Yvonne D Krom, Bogdan I Florea, Vered Raz
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006031 (2016)
Poly(A) Binding Protein Nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing, and its expression levels specifically decline in aging muscles. An expansion mutation in PABPN1 is the genetic cause of oculopharyngeal muscle dystrophy (O
Externí odkaz:
https://doaj.org/article/b01454b12f4f489ca125969f4059760f
Autor:
Bogdan I. Florea, Vered Raz, Muhammad Riaz, Cyriel Olie, Yotam Raz, Jacomina Cornelia Roorda, Guillem Paniagua-Soriano
Publikováno v:
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
Background Protein homeostasis, primarily regulated by the ubiquitin-proteasome system is crucial for proper function of cells. In tissues of post-mitotic cells, the impaired ubiquitin-proteasome system is found in a wide range of neuromuscular disor
Autor:
Vered, Raz, Yotam, Raz, Guillem, Paniagua-Soriano, Jacomina Cornelia, Roorda, Cyriel, Olie, Muhammad, Riaz, Bogdan I, Florea
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle
Background Protein homeostasis, primarily regulated by the ubiquitin–proteasome system is crucial for proper function of cells. In tissues of post‐mitotic cells, the impaired ubiquitin–proteasome system is found in a wide range of neuromuscular
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1491
Activity-based protein profiling (ABPP) is a method to highlight enzymatic activities in a biological sample, which uses chemical probes that react covalently with the catalytic nucleophile of the enzyme. To circumvent disadvantages associated with t
Publikováno v:
Methods in Molecular Biology ISBN: 9781493964376
Activity-based protein profiling (ABPP) is a method to highlight enzymatic activities in a biological sample, which uses chemical probes that react covalently with the catalytic nucleophile of the enzyme. To circumvent disadvantages associated with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5bbe1c58c11ae3de011b72bcf484776
https://doi.org/10.1007/978-1-4939-6439-0_15
https://doi.org/10.1007/978-1-4939-6439-0_15
Autor:
Yvonne D. Krom, Maaike van Putten, Vered Raz, Muhammad Riaz, Bogdan I. Florea, Yotam Raz, Guillem Paniagua-Soriano
Publikováno v:
PLOS GENETICS, 12(5)
PLoS Genetics
PLoS Genetics, Vol 12, Iss 5, p e1006031 (2016)
PLoS Genetics, 12(5)
PLOS GENETICS
PLoS Genetics
PLoS Genetics, Vol 12, Iss 5, p e1006031 (2016)
PLoS Genetics, 12(5)
PLOS GENETICS
Poly(A) Binding Protein Nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing, and its expression levels specifically decline in aging muscles. An expansion mutation in PABPN1 is the genetic cause of oculopharyngeal muscle dystrophy (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5813d7acda45b6f0a382c88b983b9fd
http://hdl.handle.net/1887/43785
http://hdl.handle.net/1887/43785
Autor:
Jürgen Bader, Lenka Besse, Andrej Besse, H den Dulk, Nico J. Meeuwenoord, Nan Li, Bart Everts, Marianne Kraus, Christoph Driessen, Herman S. Overkleeft, Bogdan I. Florea, Guillem Paniagua Soriano
Publikováno v:
Leukemia, 30, 2198-2207
Leukemia
Leukemia, 30(11), 2198-2207
Leukemia
Leukemia, 30(11), 2198-2207
Adaptive resistance of myeloma to proteasome inhibition represents a clinical challenge, whose biology is poorly understood. Proteasome mutations were implicated as underlying mechanism, while an alternative hypothesis based on low activation status
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee2802d461126fb4de93af86644892d
https://hdl.handle.net/1887/46749
https://hdl.handle.net/1887/46749
Autor:
Eva M. Huber, Gerjan de Bruin, Guillem Paniagua Soriano, Michael Groll, Wolfgang Heinemeyer, Herman S. Overkleeft
Publikováno v:
Journal of the American Chemical Society. 137(24)
Cleavage analyses of 20S proteasomes with natural or synthetic substrates allowed to infer the substrate specificities of the active sites and paved the way for the rational design of high-affinity proteasome inhibitors. However, details of cleavage
Autor:
Bogdan I. Florea, Guillem Paniagua Soriano, Jürgen Bader, Hermen S. Overkleeft, Marianne Kraus, Christoph Driessen, Andrej Besse, Lenka Besse
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 15:e232-e233
Autor:
Nan Li, Nico J. Meeuwenoord, Juergen Bader, Tobias Silzle, Marianne Kraus, Christoph Driessen, Bogdan I. Florea, Guillem Paniagua Soriano, Hans den Dulk, Lenka Besse, Herman S. Overkleeft, Andrej Besse
Publikováno v:
Blood. 126:1278-1278
Adaptive resistance of myeloma cells to proteasome inhibition is poorly understood. It is suggested to base on point mutations in PSMB5 and/or downmodulation of the activation state of the unfolded protein response (UPR) via reduced activity of its m