Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Guillem Argiles"'
Autor:
Lucia Taraborrelli, Yasin Şenbabaoğlu, Lifen Wang, Junghyun Lim, Kerrigan Blake, Noelyn Kljavin, Sarah Gierke, Alexis Scherl, James Ziai, Erin McNamara, Mark Owyong, Shilpa Rao, Aslihan Karabacak Calviello, Daniel Oreper, Suchit Jhunjhunwala, Guillem Argiles, Johanna Bendell, Tae Won Kim, Fortunato Ciardiello, Matthew J. Wongchenko, Frederic J. de Sauvage, Felipe de Sousa e Melo, Yibing Yan, Nathaniel R. West, Aditya Murthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve MSS-CRC patient outcomes. Here, we demonstrate that high t
Externí odkaz:
https://doaj.org/article/60a294e8ef9e4b37a641c0c3e8919afe
Autor:
Giulia Martini, Rodrigo Dienstmann, Javier Ros, Iosune Baraibar, Jose Luis Cuadra-Urteaga, Francesc Salva, Davide Ciardiello, Nuria Mulet, Guillem Argiles, Josep Tabernero, Elena Elez
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Colorectal cancer (CRC) is a heterogeneous disease representing a therapeutic challenge, which is further complicated by the common occurrence of several molecular alterations that confer resistance to standard chemotherapy and targeted agents. Mecha
Externí odkaz:
https://doaj.org/article/6654e5c3559c4202a4a19cbc5b7e1603
Autor:
Rodrigo Dienstmann, Elena Elez, Guillem Argiles, Ignacio Matos, Enrique Sanz‐Garcia, Carolina Ortiz, Teresa Macarulla, Jaume Capdevila, Maria Alsina, Tamara Sauri, Helena Verdaguer, Marta Vilaro, Fiorella Ruiz‐Pace, Cristina Viaplana, Ariadna Garcia, Stefania Landolfi, Hector G. Palmer, Paolo Nuciforo, Jordi Rodon, Ana Vivancos, Josep Tabernero
Publikováno v:
Molecular Oncology, Vol 11, Iss 9, Pp 1263-1272 (2017)
Sequencing of tumors is now routine and guides personalized cancer therapy. Mutant allele fractions (MAFs, or the ‘mutation dose’) of a driver gene may reveal the genomic structure of tumors and influence response to targeted therapies. We perfor
Externí odkaz:
https://doaj.org/article/db9cadd2428d4ebebd17baf85c373983
Publikováno v:
ESMO Open, Vol 4, Iss 2 (2019)
New therapeutic options for refractory metastatic colorectal cancer (mCRC) include trifluridine/tipiracil (TAS-102) and regorafenib. However, the optimal chemotherapeutic regimen for use of each agent beyond the second line for patients with mCRC rem
Externí odkaz:
https://doaj.org/article/a2e9f02994674e2d9be825c4be5041ec
Autor:
Aurelien Marabelle, Sylvie Chevret, Pierre Saintigny, Luis A. Diaz, Assia Lamrani-Ghaouti, Clotilde Simon, Frederic Legrand, Natalie Hoog-Labouret, Andrea Cercek, Neil H. Segal, Anthony Ferrari, Severine Tabone-Eglinger, Asha R. Krishnan, Guillem Argiles, Bill H. Diplas, Steven B. Maron, Michelle F. Lamendola-Essel, Dennis Stephens, Drew G. Gerber, Stephane Champiat, Jean-Charles Soria, Christophe Tournigand, Stephane Oudard, Farid El Hajbi, Diane Pannier, Thierry Andre, Olivier Bouche, Esma Saada-Bouzid, Sandrine Hiret, Frederic Rolland, Aude Flechon, Christelle de la Fouchardiere, Sophie Cousin, Muriel Duluc, Jean-Jacques Grob, Marielle Guillet, Amandine Bruyas, Rosine Guimbaud, Carlos Gomez-Roca, Damien Pouessel, Antoine Hollebecque, David Malka, Paule Augereau, Victor Simmet, Romain Cohen, Magali Svrcek, Julien Masliah-Planchon, Michael B. Foote, Valerie Attignon, Aurelien de Reynies, Lucas Michon, Nicolas Leulliot, Nadim Hamzaoui, Eric Pasmant, Ivan Bieche, Benoit Rousseau
Supplementary Figure from PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68c6d0639646b5d1548ca8532028d21
https://doi.org/10.1158/2159-8290.22541047.v1
https://doi.org/10.1158/2159-8290.22541047.v1
Autor:
Aurelien Marabelle, Sylvie Chevret, Pierre Saintigny, Luis A. Diaz, Assia Lamrani-Ghaouti, Clotilde Simon, Frederic Legrand, Natalie Hoog-Labouret, Andrea Cercek, Neil H. Segal, Anthony Ferrari, Severine Tabone-Eglinger, Asha R. Krishnan, Guillem Argiles, Bill H. Diplas, Steven B. Maron, Michelle F. Lamendola-Essel, Dennis Stephens, Drew G. Gerber, Stephane Champiat, Jean-Charles Soria, Christophe Tournigand, Stephane Oudard, Farid El Hajbi, Diane Pannier, Thierry Andre, Olivier Bouche, Esma Saada-Bouzid, Sandrine Hiret, Frederic Rolland, Aude Flechon, Christelle de la Fouchardiere, Sophie Cousin, Muriel Duluc, Jean-Jacques Grob, Marielle Guillet, Amandine Bruyas, Rosine Guimbaud, Carlos Gomez-Roca, Damien Pouessel, Antoine Hollebecque, David Malka, Paule Augereau, Victor Simmet, Romain Cohen, Magali Svrcek, Julien Masliah-Planchon, Michael B. Foote, Valerie Attignon, Aurelien de Reynies, Lucas Michon, Nicolas Leulliot, Nadim Hamzaoui, Eric Pasmant, Ivan Bieche, Benoit Rousseau
Supplementary Data from PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a66d609cc79fa4d01bedd59b08afcf
https://doi.org/10.1158/2159-8290.22541062
https://doi.org/10.1158/2159-8290.22541062
Autor:
Aurelien Marabelle, Sylvie Chevret, Pierre Saintigny, Luis A. Diaz, Assia Lamrani-Ghaouti, Clotilde Simon, Frederic Legrand, Natalie Hoog-Labouret, Andrea Cercek, Neil H. Segal, Anthony Ferrari, Severine Tabone-Eglinger, Asha R. Krishnan, Guillem Argiles, Bill H. Diplas, Steven B. Maron, Michelle F. Lamendola-Essel, Dennis Stephens, Drew G. Gerber, Stephane Champiat, Jean-Charles Soria, Christophe Tournigand, Stephane Oudard, Farid El Hajbi, Diane Pannier, Thierry Andre, Olivier Bouche, Esma Saada-Bouzid, Sandrine Hiret, Frederic Rolland, Aude Flechon, Christelle de la Fouchardiere, Sophie Cousin, Muriel Duluc, Jean-Jacques Grob, Marielle Guillet, Amandine Bruyas, Rosine Guimbaud, Carlos Gomez-Roca, Damien Pouessel, Antoine Hollebecque, David Malka, Paule Augereau, Victor Simmet, Romain Cohen, Magali Svrcek, Julien Masliah-Planchon, Michael B. Foote, Valerie Attignon, Aurelien de Reynies, Lucas Michon, Nicolas Leulliot, Nadim Hamzaoui, Eric Pasmant, Ivan Bieche, Benoit Rousseau
Missense mutations in the polymerase epsilon (POLE) gene have been reported to generate proofreading defects resulting in an ultramutated genome and to sensitize tumors to checkpoint blockade immunotherapy. However, many POLE-mutated tumors do not re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a36140e69ccd60ecf121a937d16ebe
https://doi.org/10.1158/2159-8290.c.6549541
https://doi.org/10.1158/2159-8290.c.6549541
Autor:
Ramon Salazar, Gabriel Capellá, Josep Tabernero, Clara Montagut, Rodrigo Dienstmann, Elena Elez, Guillem Argiles, Beatriz Bellosillo, Victor Moreno, Robert Montal, Joana Vidal, Fátima Marin, Xavier Sanjuan, Marga Nadal, Julieta Grasselli, Adriana Lopez-Doriga, Cristina Santos, Daniel Azuara
The clinical significance of low-frequent RAS pathway–mutated alleles and the optimal sensitivity cutoff value in the prediction of response to anti-EGFR therapy in metastatic colorectal cancer (mCRC) patients remains controversial. We aimed to eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f089bb17015905d5c0710a2ec015a060
https://doi.org/10.1158/1535-7163.c.6538722.v1
https://doi.org/10.1158/1535-7163.c.6538722.v1
Autor:
Ramon Salazar, Gabriel Capellá, Josep Tabernero, Clara Montagut, Rodrigo Dienstmann, Elena Elez, Guillem Argiles, Beatriz Bellosillo, Victor Moreno, Robert Montal, Joana Vidal, Fátima Marin, Xavier Sanjuan, Marga Nadal, Julieta Grasselli, Adriana Lopez-Doriga, Cristina Santos, Daniel Azuara
Estimation of the prediction quality of mutational status for treatment response. First column (AUC) indicates the Area Under the Curve as a prediction quality measure for all mutation groups. As expected, the AUC increases for lower mutation frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e7afb10573dc09ba9e7c45a26f7697
https://doi.org/10.1158/1535-7163.22507551.v1
https://doi.org/10.1158/1535-7163.22507551.v1
Autor:
Neil H. Segal, Ignacio Melero, Victor Moreno, Neeltje Steeghs, Aurelien Marabelle, Kristoffer Rohrberg, Maria E. Rodriguez-Ruiz, Joseph P. Eder, Cathy Eng, Gulam A. Manji, Daniel Waterkamp, Barbara Leutgeb, Said Bouseida, Nick Flinn, Meghna Das Thakur, Markus C. Elze, Hartmut Koeppen, Candice Jamois, Meret Martin-Facklam, Christopher H. Lieu, Emiliano Calvo, Luis Paz-Ares, Josep Tabernero, Guillem Argilés
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cibisatamab is a bispecific antibody-based construct targeting carcinoembryonic antigen (CEA) on tumour cells and CD3 epsilon chain as a T-cell engager. Here we evaluated cibisatamab for advanced CEA-positive solid tumours in two open-label
Externí odkaz:
https://doaj.org/article/c7ab25df143a4df7a0b711f295ef7d2c