Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Guillaume Rey"'
Autor:
Diana Avalos, Guillaume Rey, Diogo M. Ribeiro, Anna Ramisch, Emmanouil T. Dermitzakis, Olivier Delaneau
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
An analysis of cis-regulatory domains (CRDs) among monocytes, neutrophils, and T cells derived from ChIP-seq peaks and methylation data suggests cell-type specific regulatory mechanisms of immunity.
Externí odkaz:
https://doaj.org/article/32975dc4f57f4a8c9b7aaf8d5781771f
Autor:
Neha Mishra, Konrad Aden, Johanna I. Blase, Nathan Baran, Dora Bordoni, Florian Tran, Claudio Conrad, Diana Avalos, Charlot Jaeckel, Michael Scherer, Signe B. Sørensen, Silja H. Overgaard, Berenice Schulte, Susanna Nikolaus, Guillaume Rey, Gilles Gasparoni, Paul A. Lyons, Joachim L. Schultze, Jörn Walter, Vibeke Andersen, SYSCID Consortium, Emmanouil T. Dermitzakis, Stefan Schreiber, Philip Rosenstiel
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background and aims Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated the dynamic
Externí odkaz:
https://doaj.org/article/533221e6756c4c1d84dece9aba5649b6
Autor:
Florence Bettens, Halit Ongen, Guillaume Rey, Stéphane Buhler, Zuleika Calderin Sollet, Emmanouil Dermitzakis, Jean Villard
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010212 (2022)
The Human Leukocyte Antigen (HLA) is a critical genetic system for different outcomes after solid organ and hematopoietic cell transplantation. Its polymorphism is usually determined by molecular technologies at the DNA level. A potential role of HLA
Externí odkaz:
https://doaj.org/article/a038c0b3e22347ce9facd0fa2d01468a
Autor:
Ratnasekhar Ch, Guillaume Rey, Sandipan Ray, Pawan K. Jha, Paul C. Driscoll, Mariana Silva Dos Santos, Dania M. Malik, Radoslaw Lach, Aalim M. Weljie, James I. MacRae, Utham K. Valekunja, Akhilesh B. Reddy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Red blood cells, which do not possess a nucleus, have circadian redox rhythms with incompletely understood regulatory mechanisms. Here the authors show that glucose metabolism plays a crucial role in regulating circadian redox status of human red blo
Externí odkaz:
https://doaj.org/article/5f02b6e3c1e54ddcb29ebb7ccce4706e
Autor:
Crispin Zavala-Alvarado, Odile Sismeiro, Rachel Legendre, Hugo Varet, Giovanni Bussotti, Jan Bayram, Samuel G Huete, Guillaume Rey, Jean-Yves Coppée, Mathieu Picardeau, Nadia Benaroudj
Publikováno v:
PLoS Pathogens, Vol 16, Iss 10, p e1008904 (2020)
Pathogenic Leptospira spp. are the causative agents of the waterborne zoonotic disease leptospirosis. Leptospira are challenged by numerous adverse conditions, including deadly reactive oxygen species (ROS), when infecting their hosts. Withstanding R
Externí odkaz:
https://doaj.org/article/0879ef5aa50747b78623308bab87061d
Autor:
Guillaume Rey, Nikolay B Milev, Utham K Valekunja, Ratnasekhar Ch, Sandipan Ray, Mariana Silva Dos Santos, Andras D Nagy, Robin Antrobus, James I MacRae, Akhilesh B Reddy
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 8, Pp 1-11 (2018)
Abstract Circadian rhythms are cell‐autonomous biological oscillations with a period of about 24 h. Current models propose that transcriptional feedback loops are the primary mechanism for the generation of circadian oscillations. Within this frame
Externí odkaz:
https://doaj.org/article/d877c8d6c39f40e19523d13c606e6993
Autor:
Jonathan Aryeh Sobel, Irina Krier, Teemu Andersin, Sunil Raghav, Donatella Canella, Federica Gilardi, Alexandra Styliani Kalantzi, Guillaume Rey, Benjamin Weger, Frédéric Gachon, Matteo Dal Peraro, Nouria Hernandez, Ueli Schibler, Bart Deplancke, Felix Naef, CycliX consortium
Publikováno v:
PLoS Biology, Vol 15, Iss 4, p e2001069 (2017)
Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by transcription-translation feedback loops of the core circadian clock and by feeding-fasting
Externí odkaz:
https://doaj.org/article/7d6fad3d697d43e5a06a2218bd903837
Publikováno v:
PLoS Biology, Vol 9, Iss 2, p e1000595 (2011)
The mammalian circadian clock uses interlocked negative feedback loops in which the heterodimeric basic helix-loop-helix transcription factor BMAL1/CLOCK is a master regulator. While there is prominent control of liver functions by the circadian cloc
Externí odkaz:
https://doaj.org/article/c2ee8c98031d4142ad02218a776e5d72
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 2, p e38 (2008)
Circadian oscillator networks rely on a transcriptional activator called CLOCK/CYCLE (CLK/CYC) in insects and CLOCK/BMAL1 or NPAS2/BMAL1 in mammals. Identifying the targets of this heterodimeric basic-helix-loop-helix (bHLH) transcription factor pose
Externí odkaz:
https://doaj.org/article/4879e187d2dd4cf59d66f57d4f9c2799
Autor:
Diana Avalos, Guillaume Rey, Diogo M. Ribeiro, Anna Ramisch, Emmanouil Dermitzakis, Olivier Delaneau
Studying the interplay between genetic variation, epigenetic changes and regulation of gene expression in immune cells is important to understand the modification of cellular states in various conditions, including immune diseases. Here, we built cis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17b6bd416f345bd34cccd785be3cae9e
https://doi.org/10.21203/rs.3.rs-1897960/v1
https://doi.org/10.21203/rs.3.rs-1897960/v1
