Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Guillaume Luxardi"'
Autor:
Jonathan W. Riess, MD, Matthew S. Lara, BS, Miguel Lopez de Rodas, MD, Guillaume Luxardi, PhD, Samantha Herbert, MSPH, Michiko Shimoda, PhD, Karen Kelly, MD, Alexander Meerlev, PhD, Elizabeth Moore, MD, Laurel Beckett, PhD, Arta Monjazeb, MD, PhD, Kurt Schalper, MD, PhD, Emanual Maverakis, MD, David R. Gandara, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 10, Pp 100706- (2024)
Introduction: EGFR-mutated NSCLC is minimally responsive to programmed cell death protein 1 or programmed death-ligand 1 blockade. We evaluated the safety, tolerability, and immunomodulatory effects of the EGFR tyrosine kinase inhibitor (TKI) afatini
Externí odkaz:
https://doaj.org/article/863cfd19d5dc48c7a90762bd86354f28
Autor:
Arta M. Monjazeb, Megan E. Daly, Guillaume Luxardi, Emanual Maverakis, Alexander A. Merleev, Alina I. Marusina, Alexander Borowsky, Amin Mirhadi, Stephen L. Shiao, Laurel Beckett, Shuai Chen, David Eastham, Tianhong Li, Logan V. Vick, Heather M. McGee, Frances Lara, Leslie Garcia, Leigh Anne Morris, Robert J. Canter, Jonathan W. Riess, Kurt A. Schalper, William J. Murphy, Karen Kelly
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Stereotactic ablative radiotherapy (SABR) is a standard-of-care for medically-inoperable-early-stage non-small cell lung cancer (NSCLC). One third of patients progress and chemotherapy is rarely used in this population. We questioned if addi
Externí odkaz:
https://doaj.org/article/28952647439e48d680160b1ba89a37c4
Autor:
Alexander Merleev, Antonio Ji-Xu, Atrin Toussi, Lam C. Tsoi, Stephanie T. Le, Guillaume Luxardi, Xianying Xing, Rachael Wasikowski, William Liakos, Marie-Charlotte Brüggen, James T. Elder, Iannis E. Adamopoulos, Yoshihiro Izumiya, Annie R. Leal, Qinyuan Li, Nikolay Y. Kuzminykh, Amanda Kirane, Alina I. Marusina, Johann E. Gudjonsson, Emanual Maverakis
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the LDL receptor (LDLR). Recent studies have proposed a role for PCSK9 in regulating immune responses. Using RNA-Seq–based variant discovery, we identified a
Externí odkaz:
https://doaj.org/article/0af5f0392e5144bb91cb11d1e06f87ed
Autor:
Alexander A. Merleev, Stephanie T. Le, Claire Alexanian, Atrin Toussi, Yixuan Xie, Alina I. Marusina, Steven M. Watkins, Forum Patel, Allison C. Billi, Julie Wiedemann, Yoshihiro Izumiya, Ashish Kumar, Ranjitha Uppala, J. Michelle Kahlenberg, Fu-Tong Liu, Iannis E. Adamopoulos, Elizabeth A. Wang, Chelsea Ma, Michelle Y. Cheng, Halani Xiong, Amanda Kirane, Guillaume Luxardi, Bogi Andersen, Lam C. Tsoi, Carlito B. Lebrilla, Johann E. Gudjonsson, Emanual Maverakis
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
The epidermis is the outermost layer of skin. Here, we used targeted lipid profiling to characterize the biogeographic alterations of human epidermal lipids across 12 anatomically distinct body sites, and we used single-cell RNA-Seq to compare kerati
Externí odkaz:
https://doaj.org/article/29f7b5c3c7314462ae63385c896e06c5
Autor:
Evan Austin, Eugene Koo, Alexander Merleev, Denis Torre, Alina Marusina, Guillaume Luxardi, Andrew Mamalis, Roslyn Rivkah Isseroff, Avi Ma’ayan, Emanual Maverakis, Jared Jagdeo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Fibrosis occurs when collagen deposition and fibroblast proliferation replace healthy tissue. Red light (RL) may improve skin fibrosis via photobiomodulation, the process by which photosensitive chromophores in cells absorb visible or near-i
Externí odkaz:
https://doaj.org/article/1a227c143dba4b9495dc0bf4c116257c
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Reactive oxygen species (ROS) and hypoxia-inducible factors (HIF) mediate regeneration but how is unclear. Here, the authors use an optic-based probe (‘optrode’) to monitor oxygen (O2) during Xenopus tail regeneration, identifying crosstalk betwe
Externí odkaz:
https://doaj.org/article/f3ab9ec838cc49768feff3e1cc2f2ef9
Autor:
Yaohui Sun, Brian Reid, Fernando Ferreira, Guillaume Luxardi, Li Ma, Kristen L Lokken, Kan Zhu, Gege Xu, Yuxin Sun, Volodymyr Ryzhuk, Betty P Guo, Carlito B Lebrilla, Emanual Maverakis, Alex Mogilner, Min Zhao
Publikováno v:
PLoS Biology, Vol 17, Iss 4, p e3000044 (2019)
Many bacterial pathogens hijack macrophages to egress from the port of entry to the lymphatic drainage and/or bloodstream, causing dissemination of life-threatening infections. However, the underlying mechanisms are not well understood. Here, we repo
Externí odkaz:
https://doaj.org/article/88c7cf53dc304ac887f6d9ef388fdeaf
Autor:
Stephanie T. Le, Alexander A. Merleev, Guillaume Luxardi, Michiko Shimoda, Iannis E. Adamopoulos, Lam C. Tsoi, Jenny Z. Wang, Claire Alexanian, Siba P. Raychaudhuri, Samuel T. Hwang, Johann Gudjonsson, Alina I. Marusina, Emanual Maverakis
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The present paradigm of psoriasis pathogenesis revolves around the IL-23/IL-17A axis. Dual-secreting Th17 T cells presumably are the predominant sources of the psoriasis phenotype-driving cytokines, IL-17A and IL-22. We thus conducted a meta-analysis
Externí odkaz:
https://doaj.org/article/ee793b68b8a74bf49f481c9601c520be
Autor:
Elizabeth A. Wang, Andrea Steel, Guillaume Luxardi, Anupam Mitra, Forum Patel, Michelle Y. Cheng, Reason Wilken, Jason Kao, Kristopher de Ga, Hawa Sultani, Alexander A. Merleev, Alina I. Marusina, Alain Brassard, Maxwell A. Fung, Thomas Konia, Michiko Shimoda, Emanual Maverakis
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
BackgroundPyoderma gangrenosum (PG) is a debilitating ulcerative skin disease that is one of the most common associated diseases seen in patients with inflammatory bowel disease and rheumatoid arthritis. Although PG is classified as a neutrophilic de
Externí odkaz:
https://doaj.org/article/fe3ea2b9197646ba9e0c3fd94e1b89c6
Autor:
Pierluigi Scerbo, Fabrice Girardot, Céline Vivien, Gabriel V Markov, Guillaume Luxardi, Barbara Demeneix, Laurent Kodjabachian, Laurent Coen
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36855 (2012)
Vertebrate development requires progressive commitment of embryonic cells into specific lineages through a continuum of signals that play off differentiation versus multipotency. In mammals, Nanog is a key transcription factor that maintains cellular
Externí odkaz:
https://doaj.org/article/9b009d475c41471ebfce853cd84048f7