Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Guillaume Lemercier"'
Autor:
Bharath Srinivasan, Juan Daniel Flórez Weidinger, Xiang Zhai, Guillaume Lemercier, Timothy Ikeda, Mark Brewer, Bairu Zhang, Stephan Heyse, Jonathan Wingfield, Stephan Steigele
Publikováno v:
SLAS Discovery, Vol 27, Iss 8, Pp 460-470 (2022)
Recent efforts for increasing the success in drug discovery focus on an early, massive, and routine mechanistic and/or kinetic characterization of drug-target engagement as part of a design-make-test-analyze strategy. From an experimental perspective
Externí odkaz:
https://doaj.org/article/a2126a1a1f8f429598c4f15e9ed9a831
Autor:
Valerio Ortenzi, Garry Douglas, Barbara Romagnoli, Yasmeen Sarfraz, Fawaz M. Alotaibi, Awab T. Tayyib, Luis Chiriboga, David Zagzag, Jean-Pierre Gagner, Guillaume Lemercier, Eric Chevalier, Klaus Dembowsky, Michel Schmitt, Gerald Tuffin
Resistance to antiangiogenic therapy in glioblastoma (GBM) patients may involve hypoxia-induced expression of C-X-C motif chemokine receptor 4 (CXCR4) on invading tumor cells, macrophage/microglial cells (MGCs), and glioma stem cells (GSCs). We deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427df2b12f9e81f1788e20147d820c2a
https://europepmc.org/articles/PMC5809520/
https://europepmc.org/articles/PMC5809520/
Publikováno v:
Angewandte Chemie. 119:4359-4362
Reference LIP-ARTICLE-2008-006doi:10.1002/anie.200700408View record in Web of Science Record created on 2008-06-09, modified on 2017-05-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c9fd6242f42a3eb65a8a311cf31f5c
https://doi.org/10.1002/ange.200700408
https://doi.org/10.1002/ange.200700408
Autor:
Robert Gerlai, Bryan C Hains, Matt J Barnes, David J Miller, William Davies, Tom Misteli, Dipak K Sarker, Mauro Perretti, Eric D Spitzer, Laurel L Lenz, Norbert Bakalara, Guillaume Lemercier, Robert H Insall
Publikováno v:
Drug Discovery Today. 9:93-97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4acb152f9419ee77e6fa0372bb177fab
https://doi.org/10.1016/s1359-6446(03)02923-4
https://doi.org/10.1016/s1359-6446(03)02923-4
Autor:
Stephanie Gibert, Norbert Bakalara, Xavier Santarelli, Théo Baltz, Dominique Baltz, Guillaume Lemercier, Sandrine Dutoya
Publikováno v:
Journal of Biological Chemistry. 276:49117-49124
Kinesins are cytoskeletal motor proteins that play roles in a variety of fundamental cellular processes including cell division and the anterograde transport of vesicles and organelles. We purified, cloned, and functionally characterized in Trypanoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6f26729459e646d6dd9a0df39fe685
https://doi.org/10.1074/jbc.m105962200
https://doi.org/10.1074/jbc.m105962200
Autor:
Benoit Espiau, Gilles Merlin, Audrey Ambit, Guillaume Lemercier, Frédéric Bringaud, Théo Baltz, Norbert Bakalara
Publikováno v:
The Journal of biological chemistry. 281(3)
We report the functional characterization in Leishmania amazonensis of a soluble pyrophosphatase (LaVSP1) that localizes in acidocalcisomes, a vesicular acidic compartment. LaVSP1 is preferentially expressed in metacyclic forms. Experiments with domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc27c8ba621596880dac12ea9b650f2b
https://pubmed.ncbi.nlm.nih.gov/16291745
https://pubmed.ncbi.nlm.nih.gov/16291745
Autor:
Théo Baltz, Felix A. Ruiz, Guillaume Lemercier, Benoit Espiau, Roberto Docampo, Mauricio Vieira, Shuhong Luo, Norbert Bakalara
Publikováno v:
The Journal of biological chemistry. 279(5)
We report the functional characterization of a soluble pyrophosphatase (TbVSP1), which localizes to acidocalcisomes, a vesicular acidic compartment of Trypanosoma brucei. Depending on the pH and the cofactors Mg(2+) or Zn(2+), both present in the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f89b0134833284badd184e2251de1c
https://pubmed.ncbi.nlm.nih.gov/14615483
https://pubmed.ncbi.nlm.nih.gov/14615483
Autor:
Kai Johnsson, Guillaume Lemercier
The tight interaction between the small molecule biotin and the tetrameric protein streptavidin is widely exploited for many different applications in protein science. In this issue, researchers present the design of a monovalent streptavidin tetrame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb67765dbafa26fa297c1b2f54e591b
https://infoscience.epfl.ch/record/125023
https://infoscience.epfl.ch/record/125023