Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Guillaume Cognet"'
1
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3 -Mutant Leukemia
Autor: Marie Sabatier, Rudy Birsen, Laura Lauture, Sarah Mouche, Paolo Angelino, Jonas Dehairs, Lea Goupille, Ismael Boussaid, Mael Heiblig, Emeline Boet, Ambrine Sahal, Estelle Saland, Juliana C. Santos, Marc Armengol, Miranda Fernandez-Serrano, Thomas Farge, Guillaume Cognet, Federico Simonetta, Corentin Pignon, Antoine Graffeuil, Celine Mazzotti, Herve Avet-Loiseau, Oceane Delos, Justine Bertrand-Michel, Amelie Chedru, Vilma Dembitz, Paolo Gallipoli, Natasha S. Anstee, Sun Loo, Andrew H. Wei, Martin Carroll, Armelle Goubard, Remy Castellano, Yves Collette, Francois Vergez, Veronique Mansat-De Mas, Sarah Bertoli, Suzanne Tavitian, Muriel Picard, Christian Recher, Nathalie Bourges-Abella, Fanny Granat, Olivier Kosmider, Pierre Sujobert, Benoit Colsch, Carine Joffre, Lucille Stuani, Johannes V. Swinnen, Herve Guillou, Gael Roue, Nawad Hakim, Anne S. Dejean, Petros Tsantoulis, Clement Larrue, Didier Bouscary, Jerome Tamburini, Jean-Emmanuel Sarry
Publikováno v: Cancer Discovery
Cancer Discovery, 2023, 13 (7), pp.1720-1747. ⟨10.1158/2159-8290.CD-22-0411⟩
Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely unknown in cancer. Here, multiomics analyses uncovered a coordinated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fd3924e83dedc872384ed373873c22
https://hal.inrae.fr/hal-04166110
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5
Activation of Vitamin D Receptor Pathway Enhances Differentiating Capacity in Acute Myeloid Leukemia with Isocitrate Dehydrogenase Mutations
Autor: Pierre Bories, Sonia Zaghdoudi, Jean-Emmanuel Sarry, Florence Castelli, Héléna Boutzen, Alexis Hucteau, Sarah Bertoli, Marie Sabatier, Ambrine Sahal, Laura Lauture, Thomas Farge, Vera Pancaldi, Emeline Chu-Van, Lucille Stuani, Emeline Boet, Nathaniel Polley, Christian Récher, Nathan Guiraud, Guillaume Cognet, Estelle Saland, Véronique Mansat-De Mas
Publikováno v: Cancers
Volume 13
Issue 20
Cancers, Vol 13, Iss 5243, p 5243 (2021)
Simple Summary Around 15% of acute myeloid leukemia (AML) patients harbor mutations in isocitrate dehydrogenases (IDH), which lead to the production of the oncometabolite 2-hydroxyglutarate (2-HG). Inhibitors of mutant IDH enzymes and their 2-HG prod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147659ba5f1edabb08bc2d51337095a6
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6
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
Autor: Lara Gales, Camille Montersino, Marc Conti, Pierre Bories, Courtney D. DiNardo, Brandon Nicolay, Fabien Jourdan, Nicolas Broin, Mohsen Hosseini, Guillaume Cognet, Yves Gibon, Marie Sabatier, Tony Kaoma, Marina Konopleva, Lucille Stuani, Mathilde Gotanègre, Christian Recher, Laurent Fernando, Vera Pancaldi, Nathalie Poupin, Estelle Saland, Jean-Emmanuel Sarry, Joseph R. Marszalek, Andrei Turtoi, Thomas Farge, Feng Wang, Yves Collette, Laurent Le Cam, Madi Y. Cissé, Cédric Cassan, Alexis Hucteau, Claudie Bosc, Natalia Baran, Sebastien Ronseaux, Aliki Zavoriti, François Fenaille, Florence Castelli, Laetitia K. Linares, Evgenia Turtoi, Emeline Chu-Van, Martin Carroll, Pierre-Luc Mouchel, Mary A. Selak, Guillaume Cazals, Emeline Boet, Rémy Castellano, Floriant Bellvert, Norbert Vey, Clément Larrue, Koichi Takahashi, Ambrine Sahal, Sylvain Loric, Jean-Charles Portais
Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2021, 218 (5), pp.e20200924. ⟨10.1084/jem.20200924⟩
Journal of Experimental Medicine, Rockefeller University Press, 2021, 218 (5), ⟨10.1084/jem.20200924⟩
The Journal of Experimental Medicine
Stuani et al. demonstrate that IDH mutant AML cells display an enhanced mitochondrial phenotype, which is not reversed by IDH mutant inhibitors. This study provides a scientific rationale for combinatory mitochondrial-targeted therapies to treat IDH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfb2b30f8b948c067d643d1119fbb0e
https://amu.hal.science/hal-03563454/file/jStuani_em_20200924.pdf
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7
Combinatory therapy targeting mitochondrial oxidative phosphorylation improves efficacy of IDH mutant inhibitors in acute myeloid leukemia
Autor: Floriant Bellvert, Camille Montersino, Pierre-Luc Mouchel, Brandon Nicolay, Guillaume Cazals, Laurent Fernando, Nicolas Broin, Jean-Charles Portais, Joe Marszalek, Clément Larrue, Norbert Vey, Sebastien Ronseaux, Thomas Farge, Jean-Emmanuel Sarry, Andrei Turtoi, Aliki Zavoriti, Tony Kaoma, Courtney D. DiNardo, Emeline Chu-Van, Claudie Bosc, Guillaume Cognet, Rémy Castellano, Héléna Boutzen, Cédric Cassan, Claire Calmettes, Florence Castelli, Marie Sabatier, Arnaud Pigneux, Evgenia Turtoi, Yves Collette, Martin Carroll, Yves Gibon, Emeline Boet, Laetitia K. Linares, Mathilde Gotanègre, Francois Fenaille, Laurent Le Cam, Lara Gales, Marc Conti, Nathalie Poupin, Mary A. Selak, Lucille Stuani, Andrew Futreal, Christian Recher, Marina Konopleva, Feng Wang, Estelle Saland, Mohsen Hosseini, Audrey Bidet, Kiyomi Morita, Natalia Baran, Koichi Takahashi, Sylvain Loric, Pierre Bories, Fabien Jourdan
Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, BCL-2 dependence and susceptibility to mitochondrial inhibitors in cance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55157cd88bc325916e6636c39f8f7b18
https://hal.archives-ouvertes.fr/hal-02935177
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