Activity of Hydrophilic, Biocompatible, Fluorescent, Organic Nanoparticles Functionalized with Purpurin-18 in Photodynamic Therapy for Colorectal Cancer

Autor: Rayan Chkair, Justine Couvez, Frédérique Brégier, Mona Diab-Assaf, Vincent Sol, Mireille Blanchard-Desce, Bertrand Liagre, Guillaume Chemin

Publikováno v: Nanomaterials, Vol 14, Iss 19, p 1557 (2024)

Photodynamic therapy (PDT) is a clinically approved, non-invasive therapy currently used for several solid tumors, triggering cell death through the generation of reactive oxygen species (ROS). However, the hydrophobic nature of most of the photosens

Externí odkaz: https://doaj.org/article/e0fa90c4eaa24640891b175dca963287

Hydrophilic Biocompatible Fluorescent Organic Nanoparticles as Nanocarriers for Biosourced Photosensitizers for Photodynamic Therapy

Autor: Isabelle Sasaki, Frédérique Brégier, Guillaume Chemin, Jonathan Daniel, Justine Couvez, Rayan Chkair, Michel Vaultier, Vincent Sol, Mireille Blanchard-Desce

Publikováno v: Nanomaterials, Vol 14, Iss 2, p 216 (2024)

Most photosensitizers of interest for photodynamic therapy—especially porphyrinoids and chlorins—are hydrophobic. To circumvent this difficulty, the use of nanocarriers is an attractive strategy. In this perspective, we have developed highly wate

Externí odkaz: https://doaj.org/article/f01ca7395f214d3394a20b28f58ba9cc

PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice

Autor: Guillaume Chemin, Sylvie Hébrard, Chloé Oudinet, Ngoc Sa Nguyen Huu, Pierre Brousset, Stéphanie Lagarde, Laura Jamrog, Vincent Fregona, Cyril Broccardo, Bastien Gerby, Cathy Quelen, Eric Delabesse, Marina Bousquet, Stéphane J. C. Mancini, Naïs Prade, Nelly Rouquié, Charlotte Cresson, Marlène Pasquet, Lucie Coster, Ahmed Amine Khamlichi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (41), pp.10357-10362. ⟨10.1073/pnas.1721678115⟩

International audience; PAX5 is a well-known haploinsufficient tumor suppressor gene in human B-cell precursor acute lymphoblastic leukemia (B-ALL) and is involved in various chromosomal translocations that fuse a part of PAX5 with other partners. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0897d5cf8c5dd337cf3b8d30ccb25c7b
https://hal.archives-ouvertes.fr/hal-02351122

Analysis of the in vitro and in vivo effects of photodynamic therapy on prostate cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives

Autor: Guillaume Chemin, David Yannick Leger, Robert Granet, Claude-Yves Couquet, Chloë Fidanzi-Dugas, Claire Carrion, Bertrand Liagre, Vincent Sol, Aurélie Perraud

Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2017, 1861 (7), pp.1676-1690. ⟨10.1016/j.bbagen.2017.02.003⟩

Background Photodynamic therapy, using porphyrins as photosensitizers (PS), has been approved in treatment of several solid tumors. However, commonly used PS induce death but also resistance pathways in cancer cells and an alteration of surrounding n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4df7aaf8a38a3b13804213cccae37a
https://pubmed.ncbi.nlm.nih.gov/28188858

Multiple RNA Surveillance Mechanisms Cooperate to Reduce the Amount of Nonfunctional Igκ Transcripts

Autor: Guillaume Chemin, Michel Cogné, Aurélien Tinguely, Fabien Lechouane, Sophie Duchez, Laurent Delpy, Christophe Sirac

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 184 (9), pp.5009-17. ⟨10.4049/jimmunol.0902949⟩

Random V(D)J junctions ensure that the diversity of the Ig primary repertoire is adapted to the vast heterogeneity of Ags. In two-thirds of cases, recombination between variable segments induces a frameshift in the open reading frame and generates a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4d229a364b6db68786ad13f78c833a
https://doi.org/10.4049/jimmunol.0902949