Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Guillaume Bossis"'
Autor:
Martine Pugnière, Bruno Robert, Pierre Martineau, Loïs Coënon, Jessy Présumey, Emilie Rigal, Hortense Courot, Caroline Multrier, Sara Zemiti, Jennifer Lambour, Marion de Toledo, Guillaume Bossis, Guillaume Cartron, Bénédicte Fauvel, Martin Villalba
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Natural killer (NK) cell therapy is considered an attractive and safe strategy for anticancer therapy. Nevertheless, when autologous or allogenic NK cells are used alone, the clinical benefit has been disappointing. This is partially due t
Externí odkaz:
https://doaj.org/article/991361b1d9be41e2b17d78fb65236edd
Autor:
Damien Dufour, Typhanie Dumontet, Isabelle Sahut-Barnola, Aude Carusi, Méline Onzon, Eric Pussard, James Jr Wilmouth, Julie Olabe, Cécily Lucas, Adrien Levasseur, Christelle Damon-Soubeyrand, Jean-Christophe Pointud, Florence Roucher-Boulez, Igor Tauveron, Guillaume Bossis, Edward T. Yeh, David T. Breault, Pierre Val, Anne-Marie Lefrançois-Martinez, Antoine Martinez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
SUMOylation is a mechanism of posttranslational modification involved in eukaryotic cell homeostasis. Here the authors report that mice unable to control SUMOylation in the adrenal cortex develop a selective defect in glucocorticoid production due to
Externí odkaz:
https://doaj.org/article/94675fdf0b57490d98010c427e95a3d3
Autor:
Ludovic Gabellier, Marion De Toledo, Mehuli Chakraborty, Dana Akl, Rawan Hallal, Mays Aqrouq, Giovanni Buonocore, Clara Recasens-Zorzo, Guillaume Cartron, Abigaïl Delort, Marc Piechaczyk, Denis Tempé, Guillaume Bossis
Publikováno v:
Haematologica, Vol 109, Iss 1 (2023)
Acute myeloid leukemias (AML) are severe hematomalignancies with dismal prognosis. The post-translational modification SUMOylation plays key roles in leukemogenesis and AML response to therapies. Here, we show that TAK-981 (subasumstat), a first-in-c
Externí odkaz:
https://doaj.org/article/b6bdcf71115d4bb8be8915ca3cbc1c90
Autor:
Moïra Rossitto, Stephanie Déjardin, Chris M. Rands, Stephanie Le Gras, Roberta Migale, Mahmoud-Reza Rafiee, Yasmine Neirijnck, Alain Pruvost, Anvi Laetitia Nguyen, Guillaume Bossis, Florence Cammas, Lionel Le Gallic, Dagmar Wilhelm, Robin Lovell-Badge, Brigitte Boizet-Bonhoure, Serge Nef, Francis Poulat
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Gonadal fate in mammals is determined during embryogenesis and is actively maintained in adulthood. This study shows that E3-SUMO ligase activity of TRIM28 is required for ovarian identity maintenance and testicular-specific gene repression in mouse
Externí odkaz:
https://doaj.org/article/ee83c64ad8d44323a3713a98d8b88a59
Autor:
Charlotte Martinat, Arthur Cormier, Joëlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Bijan Mahboubi, Si’Ana A. Coggins, Julian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, Lucile Espert, Guillaume Bossis, Pascale Lesage, Olivier Schwartz, Baek Kim, Florence Margottin-Goguet, Ali Saïb, Alessia Zamborlini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. des
Externí odkaz:
https://doaj.org/article/70d02ba8c29446d69d93dada293f5c11
Autor:
Rosa Paolillo, Mathias Boulanger, Pierre Gâtel, Ludovic Gabellier, Marion De Toledo, Denis Tempé, Rawan Hallal, Dana Akl, Jérôme Moreaux, Hayeon Baik, Elise Gueret, Christian Recher, Jean-Emmanuel Sarry, Guillaume Cartron, Marc Piechaczyk, Guillaume Bossis
Publikováno v:
Haematologica, Vol 107, Iss 11 (2022)
Resistance to chemotherapeutic drugs is a major cause of treatment failure in acute myeloid leukemias (AML). To better characterize the mechanisms of chemoresistance, we first identified genes whose expression is dysregulated in AML cells resistant t
Externí odkaz:
https://doaj.org/article/693f4bfe8c834a5588ccd2b699cb8b45
Autor:
Kyoung Ah Kang, Yea Seong Ryu, Mei Jing Piao, Kristina Shilnikova, Hee Kyoung Kang, Joo Mi Yi, Mathias Boulanger, Rosa Paolillo, Guillaume Bossis, Sung Young Yoon, Seong Bong Kim, Jin Won Hyun
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 224-235 (2018)
The therapeutic benefits offered by 5-fluorouracil (5-FU) are limited because of the acquisition of drug resistance, the main cause of treatment failure and metastasis. The ability of the cancer cells to undergo epithelial-mesenchymal transition (EMT
Externí odkaz:
https://doaj.org/article/0d84167be1b343a78e4c9d1688cba885
Publikováno v:
Viruses, Vol 13, Iss 11, p 2197 (2021)
Intrinsic immunity is orchestrated by a wide range of host cellular proteins called restriction factors. They have the capacity to interfere with viral replication, and most of them are tightly regulated by interferons (IFNs). In addition, their regu
Externí odkaz:
https://doaj.org/article/0ea1bca8f7b14219849fc86a41aad3ca
Autor:
Nadhuma Youssouf, Clara Recasens-Zorzo, Virginie Molle, Guillaume Bossis, Philippe Soubeyran, Laila Gannoun-Zaki
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8108 (2021)
Staphylococcus aureus is a commensal bacterium that causes severe infections in soft tissue and the bloodstream. During infection, S. aureus manipulates host cell response to facilitate its own replication and dissemination. Here, we show that S. aur
Externí odkaz:
https://doaj.org/article/6a4a053337274e90a9ba7304aa85db0f
Publikováno v:
Molecules, Vol 26, Iss 4, p 828 (2021)
One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is transcriptional control. This occurs via modification of virtually all classes of transcriptional actors, which include transcription factors, transcriptional c
Externí odkaz:
https://doaj.org/article/3457913ab9e0425187381873422fdf6a