Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Guillaume Albert"'
Autor:
Christer Halldin, Akihiro Takano, Elsa Y. Pioli, Laurent Grégoire, Delphine Charvin, Erwan Bezard, Thérèse Di Paolo, Rossella Medori, François Conquet, Guillaume Albert Jacques Duvey
Publikováno v:
Movement Disorders. 33:1619-1631
Background Levodopa remains the gold-standard treatment for PD. However, it becomes less effective as the disease progresses and produces debilitating side effects, such as motor fluctuations and l-dopa-induced dyskinesia. Modulation of metabotropic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ab634a16562f1c9c74adb2e46f9aad
https://doi.org/10.1002/mds.27462
https://doi.org/10.1002/mds.27462
Autor:
Ryosuke Arakawa, Delphine Charvin, Sangram Nag, Per Grybäck, Akihiro Takano, Anton Forsberg, Mahabuba Jahan, Christer Halldin, Guillaume Albert Jacques Duvey, Zhisheng Jia
Publikováno v:
Molecular Imaging and Biology. 21:500-508
Modulation of presynaptic metabotropic glutamate receptor 4 (mGlu4) by an allosteric ligand has been proposed as a promising therapeutic target in Parkinson’s disease and levodopa-induced dyskinesia. A positron emission tomography (PET) ligand for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f1a10ef964fbe4ef2e04953ebfde5c
https://doi.org/10.1007/s11307-018-1257-0
https://doi.org/10.1007/s11307-018-1257-0
Autor:
Guillaume Albert
Publikováno v:
Comparative Sociology of Examinations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4becce5c989553caf6918fc5f6d53258
https://doi.org/10.4324/9780429466243-12
https://doi.org/10.4324/9780429466243-12
Autor:
Joseph P. Walton, Robert D. Frisina, Sylvain Celanire, Guillaume Albert Jacques Duvey, Xiaoxia Zhu, Reza M. Amanipour
Publikováno v:
EMBC
Acoustic trauma can induce temporary or permanent noise-induced hearing loss (NIHL). Noise exposed animal models allow us to study the effects of various noise trauma insults on the cochlea and auditory pathways. Here we studied the short-term and lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2020d225d7578a9345b0f872c1fd11fc
https://pubmed.ncbi.nlm.nih.gov/30440607
https://pubmed.ncbi.nlm.nih.gov/30440607
Autor:
Pype Stefan Maria Christiaan, Andrés A. Trabanco, Wilhelmus Drinkenburg, Abdelah Ahnaou, María Lourdes Linares, José Manuel Alonso, Guillaume Albert Jacques Duvey, Ana Isabel de Lucas, Sonia Poli, Jean-Philippe Rocher, Terry Patrick Finn, Juan Antonio Vega, Claire Mackie, David J. Gallacher, Jesús Alcázar, Encarnación Matesanz, José Ignacio Andrés, Daniel Oehlrich, Hilde Lavreysen, Robert Johannes Lütjens, Gregor James Macdonald, José María Cid, Gary Tresadern
Publikováno v:
Journal of Medicinal Chemistry. 57:6495-6512
We previously reported the discovery of 4-aryl-substituted pyridones with mGlu2 PAM activity starting from the HTS hit 5. In this article, we describe a different exploration from 5 that led to the discovery of a novel subseries of phenylpiperidine-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a7c0b766a0c4301a3e053e7c8696b4
https://doi.org/10.1021/jm500496m
https://doi.org/10.1021/jm500496m
Autor:
José-Ignacio Andrés, Furnari R, Gregor James Macdonald, Sonia Poli, A. Ahnaou, Guillaume Albert Jacques Duvey, José María Cid, Juan Antonio Vega, Wilhelmus Drinkenburg, Philippe Cluzeau, José Manuel Alonso, D. Oehlrich, Andrés A. Trabanco, Hilde Lavreysen, Himogai H, Gary Tresadern, Nhem, María Lourdes Linares, Claire Mackie, Robert Johannes Lütjens, de Lucas Ai, Rocher Jp, Encarnación Matesanz
Publikováno v:
Journal of Medicinal Chemistry. 55:2388-2405
The discovery and characterization of compound 48, a selective and in vivo active mGlu2 receptor positive allosteric modulator (PAM), are described. A key to the discovery was the rational exploration of the initial HTS hit 13 guided by an overlay mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0308fb5c192cb1d3bbb84125fabeaf
https://doi.org/10.1021/jm2016864
https://doi.org/10.1021/jm2016864
Autor:
Robert Johannes Lütjens, Andrés A. Trabanco, Vanthea Nhem, Yves Thollon, Géraldine Poulain, Philippe Cluzeau, Rocco Furnari, Jean-Philippe Rocher, Nadia Behaj, Gregor James Macdonald, Hassan Julien Imogai, Hilde Lavreysen, José María Cid, Terry Patrick Finn, Nicolas Poirier, Sonia Poli, Emmanuel Le Poul, David D’Addona, José Ignacio Andrés, Alexandre Raux, Guillaume Albert Jacques Duvey
Publikováno v:
MedChemComm. 2:132-139
A series of N-propyl-5-substituted isoquinolones was identified as positive allosteric modulators (PAM) of metabotropic glutamate receptor 2 (mGluR2) via high-throughput screening (HTS). The subsequent synthesis and preliminary SAR exploration that l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90dd920ad8ee7d2db1f770f049686fe6
https://doi.org/10.1039/c0md00200c
https://doi.org/10.1039/c0md00200c
Autor:
Philippe Cluzeau, Hassan Julien Imogai, Mark Epping-Jordan, Alexandre Raux, Guillaume Albert Jacques Duvey, Jean-Philippe Rocher, Gregor James Macdonald, José María Cid, Ana Isabel de Lucas, Juan Antonio Vega, Vanthea Nhem, Francis Derouet, Gary Tresadern, Andrés A. Trabanco, Christelle Boléa, José Ignacio Andrés, Robert Johannes Lütjens, Daniel Oehlrich, Karim Macary, Encarnación Matesanz, Hilde Lavreysen, Terry Patrick Finn, Sonia Poli, Jessica Muller, María Lourdes Linares, Nicolas Poirier, Francoise Girard, Julen Oyarzabal, Emilie Chamelot, Emmanuel Le Poul
Publikováno v:
ACS Chemical Neuroscience. 1:788-795
The discovery and characterization of compound 48, a selective and in vivo active mGlu2 receptor positive allosteric modulator (PAM), are described. A key to the discovery was the rational exploration of the initial HTS hit 13 guided by an overlay mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f590c750783d25cc6a29610597f8f26
https://doi.org/10.1021/cn1000638
https://doi.org/10.1021/cn1000638
Autor:
Stéphane Bouchard, Louis-Georges Cournoyer, Guillaume Albert, Sylvain Chartier, Patrice Renaud, Jean Décarie
Publikováno v:
CyberPsychology & Behavior. 10:122-130
This paper presents a tentative model of the role of perceptual-motor dynamics in the emergence of the feeling of presence. A new method allowing the measure of how gaze probes three-dimensional space in immersion is used to support this model. Fract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1811f52de19d3cda7833992506049ffc
https://doi.org/10.1089/cpb.2006.9983
https://doi.org/10.1089/cpb.2006.9983