Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Guillaume, Andrey"'
A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival
Autor:
Samuel Abassah-Oppong, Matteo Zoia, Brandon J. Mannion, Raquel Rouco, Virginie Tissières, Cailyn H. Spurrell, Virginia Roland, Fabrice Darbellay, Anja Itum, Julie Gamart, Tabitha A. Festa-Daroux, Carly S. Sullivan, Michael Kosicki, Eddie Rodríguez-Carballo, Yoko Fukuda-Yuzawa, Riana D. Hunter, Catherine S. Novak, Ingrid Plajzer-Frick, Stella Tran, Jennifer A. Akiyama, Diane E. Dickel, Javier Lopez-Rios, Iros Barozzi, Guillaume Andrey, Axel Visel, Len A. Pennacchio, John Cobb, Marco Osterwalder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Approximately a quarter of the human genome consists of gene deserts, large regions devoid of genes often located adjacent to developmental genes and thought to contribute to their regulation. However, defining the regulatory functions embed
Externí odkaz:
https://doaj.org/article/ea97ba56f1764b518e534e1063bf2e68
Autor:
Fabrice Darbellay, Anna Ramisch, Lucille Lopez-Delisle, Michael Kosicki, Antonella Rauseo, Zahra Jouini, Axel Visel, Guillaume Andrey
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Chondrocyte differentiation controls skeleton development and stature. Here we provide a comprehensive map of chondrocyte-specific enhancers and show that they provide a mechanistic framework through which non-coding genetic variants can inf
Externí odkaz:
https://doaj.org/article/b064cf129fd146118f68faab2889d660
Autor:
Christopher Chase Bolt, Lucille Lopez-Delisle, Aurélie Hintermann, Bénédicte Mascrez, Antonella Rauseo, Guillaume Andrey, Denis Duboule
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its
Externí odkaz:
https://doaj.org/article/31200988e2c64a1faf824691e328c268
Autor:
Raquel Rouco, Olimpia Bompadre, Antonella Rauseo, Olivier Fazio, Rodrigue Peraldi, Fabrizio Thorel, Guillaume Andrey
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Developmental genes are frequently controlled by multiple enhancers sharing similar specificities, so deletions of such regulatory elements often fail to reveal their full function. Here the authors use the Pitx1 testbed locus to characterize the reg
Externí odkaz:
https://doaj.org/article/0b815c21fe024b74b873bddc50a6f53e
Autor:
Guillaume Andrey, Denis Duboule
Publikováno v:
Genes & Development. 37:261-276
Congenital genetic disorders affecting limb morphology in humans and other mammals are particularly well described, due to both their rather high frequencies of occurrence and the ease of their detection when expressed as severe forms. In most cases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892e02142eb224937c6c5762e4208c1f
https://doi.org/10.1101/gad.350450.123
https://doi.org/10.1101/gad.350450.123
Autor:
Hasan Asfour, Estelle Hirsinger, Raquel Rouco, Faouzi Zarrouki, Shinichiro Hayashi, Sandra Swist, Thomas Braun, Ketan Patel, Frédéric Relaix, Guillaume Andrey, Sigmar Stricker, Delphine Duprez, Amalia Stantzou, Helge Amthor
Publikováno v:
Development.
The mechanism of pattern formation during limb muscle development remains poorly understood. The canonical view holds that naïve limb muscle progenitor cells (MPCs) invade a pre-established pattern of muscle connective tissue, thereby forming indivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::894e17ad845af17e7e1e94da99dde5c6
https://doi.org/10.1242/dev.201504
https://doi.org/10.1242/dev.201504
Autor:
Fabrice Darbellay, Anna Ramisch, Lucille Lopez-Delisle, Michael Kosicki, Axel Visel, Guillaume Andrey
The precisely orchestrated differentiation of chondrocytes during skeleton development is a critical determinant of human height and body shape and disruptions of this process can cause severe skeletal abnormalities. The ultimate size and shape of ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::631f3e83aaf2238a753f98dd367e31b2
https://doi.org/10.1101/2023.05.10.539849
https://doi.org/10.1101/2023.05.10.539849
Autor:
Nayuta Yakushiji-Kaminatsui, Lucille Lopez-Delisle, Christopher Chase Bolt, Guillaume Andrey, Leonardo Beccari, Denis Duboule
Publikováno v:
PLoS Biology, Vol 16, Iss 11, p e3000004 (2018)
In all tetrapods examined thus far, the development and patterning of limbs require the activation of gene members of the HoxD cluster. In mammals, they are regulated by a complex bimodal process that controls first the proximal patterning and then t
Externí odkaz:
https://doaj.org/article/9b1719bd932d4fb380472a66623e0974
Autor:
Katerina Kraft, Sinje Geuer, Anja J. Will, Wing Lee Chan, Christina Paliou, Marina Borschiwer, Izabela Harabula, Lars Wittler, Martin Franke, Daniel M. Ibrahim, Bjørt K. Kragesteen, Malte Spielmann, Stefan Mundlos, Darío G. Lupiáñez, Guillaume Andrey
Publikováno v:
Cell Reports, Vol 10, Iss 5, Pp 833-839 (2015)
Structural variations (SVs) contribute to the variability of our genome and are often associated with disease. Their study in model systems was hampered until now by labor-intensive genetic targeting procedures and multiple mouse crossing steps. Here
Externí odkaz:
https://doaj.org/article/1dd3ee1f85b7489a97143d51e0609733
Autor:
Ivana Jerković, Daniel M Ibrahim, Guillaume Andrey, Stefan Haas, Peter Hansen, Catrin Janetzki, Irene González Navarrete, Peter N Robinson, Jochen Hecht, Stefan Mundlos
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006567 (2017)
Homeotic genes code for key transcription factors (HOX-TFs) that pattern the animal body plan. During embryonic development, Hox genes are expressed in overlapping patterns and function in a partially redundant manner. In vitro biochemical screens pr
Externí odkaz:
https://doaj.org/article/e8324d305f6947cd9b32c89f8da57fc4