Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Guilherme Z, Rocha"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Subclinical inflammation is linked to comorbidities and risk factors, consolidating the diagnosis of chronic non-communicable diseases, such as insulin resistance, atherosclerosis, hepatic steatosis, and some types of cancer. In this context, the rol
Externí odkaz:
https://doaj.org/article/fc7410d757bf41ef8d39b8c131aa743a
Autor:
Heloisa B. Assalin, Kelly Cristiane Gabriel De Almeida, Dioze Guadagnini, Andrey Santos, Caio J. Teixeira, Silvana Bordin, Guilherme Z. Rocha, Mario J. A. Saad
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13766 (2022)
Proton pump inhibitors (PPIs) are one of the most prescribed drugs around the world. PPIs induce microbiota modulation such as obesity both in humans and in animal models. However, since PPIs can induce microbiota modulation despite the absence of a
Externí odkaz:
https://doaj.org/article/0f34093903454ded8a5c2826b43f796d
Autor:
José B.C. Carvalheira, Mario J.A. Saad, Anibal E. Vercesi, Franco A. Rossato, Felipe Osório-Costa, Eduardo R. Ropelle, Marília M. Dias, Guilherme Z. Rocha
Supplementary Figure 1 from Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022884269ceaa2fe4e8ca595e53766e3
https://doi.org/10.1158/1078-0432.22441035
https://doi.org/10.1158/1078-0432.22441035
Autor:
José B.C. Carvalheira, Mario J.A. Saad, Anibal E. Vercesi, Franco A. Rossato, Felipe Osório-Costa, Eduardo R. Ropelle, Marília M. Dias, Guilherme Z. Rocha
Purpose: Metformin is a widely used antidiabetic drug whose anticancer effects, mediated by the activation of AMP-activated protein kinase (AMPK) and reduction of mTOR signaling, have become noteworthy. Chemotherapy produces genotoxic stress and indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e6510a37064d98fbf6d5585e27e745
https://doi.org/10.1158/1078-0432.c.6518217
https://doi.org/10.1158/1078-0432.c.6518217
Autor:
José B.C. Carvalheira, Mario J.A. Saad, Anibal E. Vercesi, Franco A. Rossato, Felipe Osório-Costa, Eduardo R. Ropelle, Marília M. Dias, Guilherme Z. Rocha
Supplementary Figure 2 from Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cb8fb7712b302d704862f0b0157a29
https://doi.org/10.1158/1078-0432.22441032
https://doi.org/10.1158/1078-0432.22441032
Autor:
José B.C. Carvalheira, Mario J.A. Saad, Anibal E. Vercesi, Franco A. Rossato, Felipe Osório-Costa, Eduardo R. Ropelle, Marília M. Dias, Guilherme Z. Rocha
Supplementary Figure 3 from Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44de5bc82bf96fe43851d5aa3bb8282b
https://doi.org/10.1158/1078-0432.22441029.v1
https://doi.org/10.1158/1078-0432.22441029.v1
Autor:
Natália Tobar, Guilherme Z. Rocha, Andrey Santos, Dioze Guadagnini, Heloísa B. Assalin, Juliana A. Camargo, Any E. S. S. Gonçalves, Flavia R. Pallis, Alexandre G. Oliveira, Silvana A. Rocco, Raphael M. Neto, Irene Layane de Sousa, Marcos R. Alborghetti, Maurício L. Sforça, Patrícia B. Rodrigues, Raissa G. Ludwig, Emerielle C. Vanzela, Sergio Q. Brunetto, Patrícia A. Boer, José A. R. Gontijo, Bruno Geloneze, Carla R. O. Carvalho, Patricia O. Prada, Franco Folli, Rui Curi, Marcelo A. Mori, Marco A. R. Vinolo, Celso D. Ramos, Kleber G. Franchini, Claudio F. Tormena, Mario J. A. Saad
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Metformin is the most prescribed drug for DM2, but its site and mechanism of action are still not well established. Here, we investigated the effects of metformin on basolateral intestinal glucose uptake (BIGU), and its consequences on hepatic glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4971f54712ee60754bf33b0dc0aa3f4f
Autor:
Marcelo N. Pedro, Guilherme Z. Rocha, Dioze Guadagnini, Andrey Santos, Daniela O. Magro, Heloisa B. Assalin, Alexandre G. Oliveira, Rogerio de Jesus Pedro, Mario J. A. Saad
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Here we review how immune activation and insulin resistance contribute to the metabolic alterations observed in HIV-infected patients, and how these alterations increase the risk of developing CVD. The introduction and evolution of antiretroviral dru
Externí odkaz:
https://doaj.org/article/6fd34005704c47e88252034ee55a2191
Autor:
Alexandre G. Oliveira, Tiago G. Araújo, Bruno de Melo Carvalho, Guilherme Z. Rocha, Andrey Santos, Mario J. A. Saad
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
In obesity, insulin resistance (IR) and diabetes, there are proteins and hormones that may lead to the discovery of promising biomarkers and treatments for these metabolic disorders. For example, these molecules may impair the insulin signaling pathw
Externí odkaz:
https://doaj.org/article/017227237dbf45fd9c18c0b4cfae9ce5
Autor:
Guilherme Z. Rocha, Karen L. Ferrari, Isis G. A. Kiehl, Leonardo Oliveira Reis, Marina V Ossick, Maria C B Linarelli, Ana Clara Salustiano, Giovanna Rosa Degasperi, Heloisa Balan Assalin
Publikováno v:
Nutrition and Cancer. 73:2687-2694
Evaluate tryptophan and thymine (TT) impact on carcinogenesis and intravesical BCG bladder cancer treatment.After identification of TT in vitro inhibitory effect in multiple cancer cell cultures, bladder cancer animal model was induced by MNU intrave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56306d644aea65dbc8abbeccfb814ea0
https://doi.org/10.1080/01635581.2020.1856389
https://doi.org/10.1080/01635581.2020.1856389