The PI3Kγ/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone

Autor: Fernando Q. Cunha, Thiago M. Cunha, José C. Alves-Filho, Nerry T. Cecilio, Guilherme R. Souza

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Dipyrone (DIP), also known as metamizole, is an over-the-counter analgesic used in Europe and Latin America. Evidence suggesting that inflammatory pain attenuation by DIP is associated with a direct impact on peripheral primary nociceptive neurons th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5396f9e83ca40337e52bba7a0e2a3269
https://doi.org/10.1111/fcp.12606

Meningeal dendritic cells-astrocytes interactions elevate the kynurenine metabolic pathway to sustain neuropathic pain

Autor: Guilherme R. Souza, Fernando Q. Cunha, Miriam D. Fonseca, Alexandre H. Lopes, Morena Brazil Sant'Anna, Rangel L. Silva, Gabriela A. Buqui, Jhimmy Talbot, Jason C. O’Connor, Thiago M. Cunha, Rafaela M. Guimarães, Dênis Augusto Reis Santana, Alexandre Gomes de Macedo Maganin, Norberto P. Lopes, Ricardo M. Leão, Atlante S. Mendes, Nerry T. Cecilio, Andre Dagostin, Gabriela Pacholczyk, Letícia Magalhães Arruda, Danielle S. Coelho, Marcela Davoli-Ferreira, Henrique Lemos, Lei Huang, Ricardo Kusuda, José C. Alves-Filho, Lucas Miranda Marques, Andrew L. Mellor, Francisco Isaac Fernandes Gomes

Neuropathic pain is triggered by injury to the somatosensory system, and is one of the most important types of chronic pain. Nevertheless, critical pathophysiological mechanisms that maintain neuropathic pain are poorly understood. Here, we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::278a962a7ad05317c4de2966b1899e9d
https://doi.org/10.1101/2021.01.25.428142

Aqueous humor renin, angiotensin I, and angiotensin II activity in primary open-angle glaucoma

Autor: Jayter Silva Paula, Guilherme R. Souza, Dulce Elena Casarini, Valéria Batista Boreck Seki, Andre Messias

Publikováno v: Arquivos Brasileiros de Oftalmologia v.83 n.4 2020
Arquivos brasileiros de oftalmologia
Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
Arquivos Brasileiros de Oftalmologia

Purpose: The renin-angiotensin system is involved in the pathogenesis of retinal ischemic conditions and glaucoma. Our objective was to evaluate the renin, angiotensinconverting enzyme 1, and angiotensin-converting enzyme 2 activities in aqueous humo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d49f316cebf62fc15de56ebeb9a399
https://pubmed.ncbi.nlm.nih.gov/35416904

Non-peptidergic nociceptive neurons are essential for mechanical inflammatory hypersensitivity in mice

Autor: Ricardo Kusuda, Sérgio H. Ferreira, Thiago M. Cunha, Alexandre H. Lopes, Larissa G. Pinto, Fernando Q. Cunha, Morena Brazil Sant'Anna, Guilherme R. Souza

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Small nerve fibers that bind the isolectin B4 (IB4+ C-fibers) are a subpopulation of primary afferent neurons that are involved in nociceptive sensory transduction and do not express the neuropeptides substance P and calcitonin-gene related peptide (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e462ffe2bd88dfc99b07f1aa484383f

Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization

Autor: Thiago M. Cunha, Gabriel Shimizu Bassi, Morena Brazil Sant'Anna, Ricardo Kusuda, Guilherme R. Souza, Fernando Q. Cunha, Tiago A. Bozzo, José C. Alves-Filho, Sérgio H. Ferreira

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports

Peripheral neuropathic pain is a consequence of an injury/disease of the peripheral nerves. The mechanisms involved in its pathophysiology are not entirely understood. To better understand the mechanisms involved in the development of peripheral nerv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2021f4e6a7cb94bc40aa3bdd1b823aa
https://doi.org/10.1038/srep26955