Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.

Autor: Green SR; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Davis SH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Damerow S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Engelhart CA; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Mathieson M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Baragaña B; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Robinson DA; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Tamjar J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Dawson A; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Tamaki FK; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Buchanan KI; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Post J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Dowers K; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Shepherd SM; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Jansen C; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Zuccotto F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Epemolu O; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Riley J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Stojanovski L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Osuna-Cabello M; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Pérez-Herrán E; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Rebollo MJ; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Guijarro López L; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Casado Castro P; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Camino I; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Kim HC; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Bean JM; Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA., Nahiyaan N; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Rhee KY; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Wang Q; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD, USA., Tan VY; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD, USA., Boshoff HIM; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD, USA., Converse PJ; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Li SY; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Chang YS; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Fotouhi N; Global Alliance for TB Drug Development, New York, NY, USA., Upton AM; Global Alliance for TB Drug Development, New York, NY, USA., Nuermberger EL; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA., Schnappinger D; Dept. of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA., Read KD; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Encinas L; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Bates RH; Global Health Medicines R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760, Madrid, Spain., Wyatt PG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Cleghorn LAT; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK. l.a.t.cleghorn@dundee.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 11; Vol. 13 (1), pp. 5992. Date of Electronic Publication: 2022 Oct 11.

A radiological score for the assessment of tuberculosis progression: Validation in mouse models.

Autor: Ortega-Gil A; Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain; Diseases of the Developing World, Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Madrid, Spain., Muñoz-Barrutia A; Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain. Electronic address: mamunozb@ing.uc3m.es., Roca JJ; Diseases of the Developing World, Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Madrid, Spain., Guijarro-López L; Diseases of the Developing World, Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Madrid, Spain., Vaquero JJ; Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.

Publikováno v: Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2020 Mar; Vol. 121, pp. 101918. Date of Electronic Publication: 2020 Mar 03.

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.

Autor: Keurulainen L; †Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5 E (P.O. Box 56), FI-00014 Helsinki, Finland., Vahermo M; †Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5 E (P.O. Box 56), FI-00014 Helsinki, Finland., Puente-Felipe M; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Sandoval-Izquierdo E; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Crespo-Fernández B; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Guijarro-López L; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Huertas-Valentín L; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., de las Heras-Dueña L; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Leino TO; †Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5 E (P.O. Box 56), FI-00014 Helsinki, Finland., Siiskonen A; †Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5 E (P.O. Box 56), FI-00014 Helsinki, Finland., Ballell-Pages L; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Sanz LM; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Castañeda-Casado P; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Jiménez-Díaz MB; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Martínez-Martínez MS; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Viera S; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Kiuru P; †Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5 E (P.O. Box 56), FI-00014 Helsinki, Finland., Calderón F; ‡Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Yli-Kauhaluoma J; †Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5 E (P.O. Box 56), FI-00014 Helsinki, Finland.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Jun 11; Vol. 58 (11), pp. 4573-80. Date of Electronic Publication: 2015 May 19.

Structure-Metabolism Relationships of Benzimidazole Derivatives with anti-Trypanosoma cruzi Activity for Chagas Disease.

Autor: Espinoza-Chávez RM; Laboratory of Synthetic Organic Chemistry, Institute of Chemistry, State University of Campinas (Unicamp), Campinas-SP, 13084-971, Brazil., de Oliveira Rezende Júnior C; Laboratory of Synthetic Organic Chemistry, Institute of Chemistry, State University of Campinas (Unicamp), Campinas-SP, 13084-971, Brazil.; Institute of Chemistry, Federal University of Uberlândia (UFU), Uberlândia-MG, 38400-902, Brazil., Laureano de Souza M; Laboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos (IFSC), University of Sao Paulo (USP), Sao Carlos-SP, 13563-120, Brazil., Consolin Chelucci R; Laboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos (IFSC), University of Sao Paulo (USP), Sao Carlos-SP, 13563-120, Brazil., Michelan-Duarte S; Laboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos (IFSC), University of Sao Paulo (USP), Sao Carlos-SP, 13563-120, Brazil., Krogh R; Laboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos (IFSC), University of Sao Paulo (USP), Sao Carlos-SP, 13563-120, Brazil., Gomes Ferreira LL; Laboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos (IFSC), University of Sao Paulo (USP), Sao Carlos-SP, 13563-120, Brazil., Valli M; Laboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos (IFSC), University of Sao Paulo (USP), Sao Carlos-SP, 13563-120, Brazil., Sena de Oliveira A; Laboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos (IFSC), University of Sao Paulo (USP), Sao Carlos-SP, 13563-120, Brazil.; Department of Exact Sciences and Education, Federal University of Santa Catarina (UFSC), Blumenau-SC, 89036-004, Brazil., Andricopulo AD; Laboratory of Medicinal and Computational Chemistry, Physics Institute of Sao Carlos (IFSC), University of Sao Paulo (USP), Sao Carlos-SP, 13563-120, Brazil., Carlos Dias L; Laboratory of Synthetic Organic Chemistry, Institute of Chemistry, State University of Campinas (Unicamp), Campinas-SP, 13084-971, Brazil.

Publikováno v: ChemMedChem [ChemMedChem] 2024 Oct 16; Vol. 19 (20), pp. e202400293. Date of Electronic Publication: 2024 Aug 27.

Study of the Effect of Substituents of ortho -Phenylenediamines in the Opening of Lactones and Lactams for Access to Benzimidazol-2-yl Alkanols and Benzimidazol-2-yl Alkylamines.

Autor: Castillo-Aguilera, Omar, Depreux, Patrick, Ballée, Alexia, Beaurain, Florian, Arimondo, Paola B., Goossens, Laurence

Publikováno v: Synlett; 2020, Vol. 31 Issue 12, p1216-1220, 5p