Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Guihua Sun"'
Autor:
Qi Cui, Arjit Vijey Jeyachandran, Gustavo Garcia jr., Chao Qin, Yu Zhou, Mingzi Zhang, Cheng Wang, Guihua Sun, Wei Liu, Tao Zhou, Lizhao Feng, Chance Palmer, Zhuo Li, Adam Aziz, Brigitte N. Gomperts, Pinghui Feng, Vaithilingaraja Arumugaswami, Yanhong Shi
Publikováno v:
MedComm, Vol 4, Iss 5, Pp n/a-n/a (2023)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causal agent for coronavirus disease 2019 (COVID‐19). Although vaccines have helped to prevent uncontrolled viral spreading, our understanding of the fundamental biolo
Externí odkaz:
https://doaj.org/article/81c88b3fb37e42ad884dc34e3347c863
Autor:
Guihua Sun, Qi Cui, Gustavo Garcia, Elizabeth M. Lizhar, Vaithilingaraja Arumugaswami, Yanhong Shi, Arthur D. Riggs
Publikováno v:
Microbiology Research, Vol 13, Iss 4, Pp 788-808 (2022)
After two years into the pandemic of the coronavirus disease 2019 (COVID-19), it remains unclear how the host RNA interference (RNAi) pathway and host miRNAs regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and impact t
Externí odkaz:
https://doaj.org/article/89023e9f76354f5086a76a5ad36c4835
Autor:
Lizhao Feng, Jianfei Chao, Peng Ye, Qui Luong, Guoqiang Sun, Wei Liu, Qi Cui, Sergio Flores, Natasha Jackson, Afm Nazmul Hoque Shayento, Guihua Sun, Zhenqing Liu, Weidong Hu, Yanhong Shi
Publikováno v:
Advanced Science, Vol 10, Iss 23, Pp n/a-n/a (2023)
Abstract Demyelinating disorders are among the most common and debilitating diseases in neurology. Canavan disease (CD) is a lethal demyelinating disease caused by mutation of the aspartoacylase (ASPA) gene, which leads to the accumulation of its sub
Externí odkaz:
https://doaj.org/article/09dd6e46f2554eef892a2a30ee48afbe
Autor:
Zhenqing Liu, Jianfei Chao, Cheng Wang, Guihua Sun, Daniel Roeth, Wei Liu, Xianwei Chen, Li Li, E Tian, Lizhao Feng, Hayk Davtyan, Mathew Blurton-Jones, Markus Kalkum, Yanhong Shi
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112841- (2023)
Summary: The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest known genetic risk factor for late-onset Alzheimer’s disease. However, whether this single-nucleotide polymorphism (SNP) is functional and what t
Externí odkaz:
https://doaj.org/article/77cf8d20e7704cc4ab9715b8179a709d
Autor:
Guihua Sun, Qi Cui, Gustavo Garcia, Cheng Wang, Mingzi Zhang, Vaithilingaraja Arumugaswami, Arthur D. Riggs, Yanhong Shi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The transcriptome of SARS-CoV-2-infected cells that reflects the interplay between host and virus has provided valuable insights into mechanisms underlying SARS-CoV-2 infection and COVID-19 disease progression. In this study, we show that SA
Externí odkaz:
https://doaj.org/article/0f087bf8808a4cf993b837bd93dab18a
Autor:
Jianfei Chao, Lizhao Feng, Peng Ye, Xianwei Chen, Qi Cui, Guihua Sun, Tao Zhou, E Tian, Wendong Li, Weidong Hu, Arthur D. Riggs, Reuben Matalon, Yanhong Shi
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104391- (2022)
Summary: Canavan disease (CD) is a devastating neurological disease that lacks effective therapy. Because CD is caused by mutations of the aspartoacylase (ASPA) gene, we introduced the wild-type (WT) ASPA gene into patient iPSCs through lentiviral tr
Externí odkaz:
https://doaj.org/article/ec108dc0d5d644b9b0f6d2a356457de6
Autor:
Guihua Sun, Meirigeng Qi, Alexis S. Kim, Elizabeth M. Lizhar, Olivia W. Sun, Ismail H. Al-Abdullah, Arthur D. Riggs
Publikováno v:
Non-Coding RNA, Vol 9, Iss 2, p 20 (2023)
miRNAs are critical for pancreas development and function. However, we found that there are discrepancies regarding pancreatic miRNA abundance in published datasets. To obtain a more relevant profile that is closer to the true profile, we profiled sm
Externí odkaz:
https://doaj.org/article/01f635858bac481a8ad6d4e1bf975e09
Autor:
Qi Cui, Gustavo Garcia, Jr., Mingzi Zhang, Cheng Wang, Hongzhi Li, Tao Zhou, Guihua Sun, Vaithilingaraja Arumugaswami, Yanhong Shi
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103684- (2022)
Summary: The COVID-19 outbreak poses a serious threat to global public health. Effective countermeasures and approved therapeutics are desperately needed. In this study, we screened a small molecule library containing the NCI-DTP compounds to identif
Externí odkaz:
https://doaj.org/article/16ee232fae5c4f02afb338b295fed815
Autor:
Guihua Sun, Arthur D. Riggs
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 345-355 (2017)
We have studied the molecular properties of in-vitro-transcribed sliced small interfering RNAs (tsli-siRNAs) as an alternative RNAi agent for chemically synthesized siRNA. We describe here a simple and cost-effective procedure for high-purity product
Externí odkaz:
https://doaj.org/article/ead99974bc3a4192b60f117ea40f6904
Autor:
Qi Cui, Hailing Shi, Peng Ye, Li Li, Qiuhao Qu, Guoqiang Sun, Guihua Sun, Zhike Lu, Yue Huang, Cai-Guang Yang, Arthur D. Riggs, Chuan He, Yanhong Shi
Publikováno v:
Cell Reports, Vol 18, Iss 11, Pp 2622-2634 (2017)
RNA modifications play critical roles in important biological processes. However, the functions of N6-methyladenosine (m6A) mRNA modification in cancer biology and cancer stem cells remain largely unknown. Here, we show that m6A mRNA modification is
Externí odkaz:
https://doaj.org/article/82bb54561d654155b57bf783885b88c3