Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Guihua Du"'
Autor:
Fankun Zhou, Lu Ouyang, Jie Xie, Sisi Liu, Qi Li, Shuo Yang, Jiajun Li, Rui Su, Shaoqi Rao, Lingyu Yan, Xin Wan, Hui Cheng, Peishan Liu, Lingling Li, Yanhui Zhu, Guihua Du, Chang Feng, Guangqin Fan
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 264, Iss , Pp 115425- (2023)
Lead (Pb), cadmium (Cd), and mercury (Hg) are environmentally toxic heavy metals that can be simultaneously detected at low levels in the blood of the general population. Although our previous studies have demonstrated neurodevelopmental toxicity upo
Externí odkaz:
https://doaj.org/article/6767a316d549499aa9bec8ac065feeac
Autor:
Guangqin Fan, Guihua Du, Huijun Li, Fen Lin, Ziyong Sun, Wei Yang, Chang Feng, Gaochun Zhu, Yanshu Li, Ying Chen, Huan Jiao, Fankun Zhou
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101537 (2014)
Both an excess of toxic lead (Pb) and an essential iron disorder have been implicated in many diseases and public health problems. Iron metabolism genes, such as the hemochromatosis (HFE) gene, have been reported to be modifiers for lead absorption a
Externí odkaz:
https://doaj.org/article/2aee6f13350e4b40b112a882fac43bb9
Autor:
Weiya Xu, Yiyun Zhang, Dongdong Qin, Yiqian Gui, Shu Wang, Guihua Du, Fan Yang, Lufan Li, Shuiqiao Yuan, Mei Wang, Xin Wu
Publikováno v:
Journal of Cell Science. 135
Transcription factor-like 5 (TCFL5) is a testis-specific protein that contains the basic helix-loop-helix domain, but the in vivo functions of TCFL5 remain unknown. Herein, we generated CRISPR/Cas9-mediated knockout mice to dissect the function of TC
Publikováno v:
Biology of reproduction. 106(6)
Spermatogenic regeneration is key for male fertility and relies on activities of an undifferentiated spermatogonial population. Here, a high-throughput approach with primary cultures of mouse spermatogonia was devised to rapidly predict alterations i
Publikováno v:
Development
The stem cell-containing undifferentiated spermatogonial population in mammals, which ensures continual sperm production, arises during development from prospermatogonial precursors. Although a period of quiescence is known to occur in prospermatogon
Autor:
Weiya Xu, Luping Yu, Guihua Du, Mengcheng Luo, John Zhong Li, Xin Wu, Lufan Li, P. Jeremy Wang, Jon M. Oatley, Li'e Cai, Tao Zhou, Mei Wang, Xinrui Wang
Publikováno v:
Development.
Continual spermatogenesis relies on the actions of an undifferentiated spermatogonial population that is composed of stem cells and progenitors. Here, using mouse models, we explored the role of RNA binding proteins (RBPs) in regulation of the biolog
Autor:
Yanyan Gao, Guihua Du, Guangming Yin, Fankun Zhou, Zhiping Wang, Guangqin Fan, Jie Xie, Junwang Gu, Shuyun Zhang, Qiyue Jia, Chang Feng, Yu Li
Publikováno v:
Toxicology and Applied Pharmacology. 338:103-111
Although the neurotoxic mechanism of lead (Pb2+) has been extensively studied, it is not well understood. The effects of Pb2+ on free cytosolic calcium (Ca2+) concentration and calcium-regulated events have been suggested to be major mechanisms in Pb
Autor:
Tao Zhou, Hao Zhang, Lin Qi, Yueshuai Guo, Lan Ye, Xiang Wei, Yuanyuan Xue, Min Wang, Lufan Li, Xuejiang Guo, Xin Wu, Jing Wang, Guihua Du, Mei Wang
Publikováno v:
Molecular & Cellular Proteomics. 16:982-997
Cytokine-dependent renewal of stem cells is a fundamental requisite for tissue homeostasis and regeneration. Spermatogonial progenitor cells (SPCs) including stem cells support life-long spermatogenesis and male fertility, but pivotal phosphorylation
Autor:
Zhipeng Zha, Chang Feng, Guihua Du, Qiyue Jia, Ying Fan, Han Yu, Fankun Zhou, Junwang Gu, Lu Ouyang, Jie Xie, Guangqin Fan, Kai Wang, Lijian Shao
Publikováno v:
The Science of the total environment. 701
Heavy metal lead (Pb) is widely distributed in the environment and can induce neurodegeneration. Accumulating evidence has shown that ryanodine receptors (RyRs) play vital roles in neurodegenerative brain. However, whether aberrant RyRs levels contri
Publikováno v:
Development (09501991); May2021, Vol. 148 Issue 9, p1-12, 12p