Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Guifeng Wei"'
Publikováno v:
Molecules, Vol 28, Iss 12, p 4672 (2023)
Oncogenic fusion proteins, arising from chromosomal rearrangements, have emerged as prominent drivers of tumorigenesis and crucial therapeutic targets in cancer research. In recent years, the potential of small molecular inhibitors in selectively tar
Externí odkaz:
https://doaj.org/article/0ec6a6eeeffb48f5835125cb870be03f
Autor:
Joseph S. Bowness, Tatyana B. Nesterova, Guifeng Wei, Lisa Rodermund, Mafalda Almeida, Heather Coker, Emma J. Carter, Artun Kadaster, Neil Brockdorff
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110830- (2022)
Summary: X chromosome inactivation (XCI) is mediated by the non-coding RNA Xist, which directs chromatin modification and gene silencing in cis. The RNA binding protein SPEN and associated corepressors have a central role in Xist-mediated gene silenc
Externí odkaz:
https://doaj.org/article/cbb4ebeca8874aee9b97248ef77766d9
Autor:
Yingying Lin, Ting Qiu, Guifeng Wei, Yueyue Que, Wenxin Wang, Yichao Kong, Tian Xie, Xiabin Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer’s disease, psoriasis, asthma,
Externí odkaz:
https://doaj.org/article/6fd47f308ba949da9688c098162a889d
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
AbstractTo ensure stable transmission of genetic information to the next generation, germ cells frequently silence sex chromosomes, as well as autosomal loci that promote inappropriate differentiation programs. In Caenorhabditis elegansC. elegansoef-
Externí odkaz:
https://doaj.org/article/2a067f494446407fb4b78311865f8f5e
Autor:
Tatyana B. Nesterova, Guifeng Wei, Heather Coker, Greta Pintacuda, Joseph S. Bowness, Tianyi Zhang, Mafalda Almeida, Bianca Bloechl, Benoit Moindrot, Emma J. Carter, Ines Alvarez Rodrigo, Qi Pan, Ying Bi, Chun-Xiao Song, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Xist RNA is the master regulator of X chromosome inactivation. Here the authors describe a systematic analysis of Xist-mediated allelic silencing in mouse ESC models and define the contribution of different pathways that regulate gene silencing.
Externí odkaz:
https://doaj.org/article/1099fcaec9864035a2a87b2701f1ba55
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background The wide variety of specialized permissive and repressive mechanisms by which germ cells regulate developmental gene expression are not well understood genome-wide. Isolation of germ cells with high integrity and purity from livin
Externí odkaz:
https://doaj.org/article/da20cb9d1f374945acce6b84f10fba4b
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101741- (2020)
Summary: Transcriptional fidelity depends on accurate promoter selection and initiation from the correct sites. In yeast, H3K36me3-mediated recruitment of the Rpd3S HDAC complex to gene bodies suppresses spurious transcription initiation. Here we des
Externí odkaz:
https://doaj.org/article/a018d1b1e063427d8727a4e6c17a474f
Autor:
Heather Coker, Guifeng Wei, Benoit Moindrot, Shabaz Mohammed, Tatyana Nesterova, Neil Brockdorff
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Background: X chromosome inactivation in mammals is regulated by the non-coding (nc) RNA, Xist, which represses the chromosome from which it is transcribed. High levels of the N6-methyladenosine (m6A) RNA modification occur within Xist exon I, close
Externí odkaz:
https://doaj.org/article/b298b9adf43348348402ac34948230ba
A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
Autor:
Tianyi Zhang, Guifeng Wei, Christopher J. Millard, Roman Fischer, Rebecca Konietzny, Benedikt M. Kessler, John W. R. Schwabe, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Transcription regulation requires recruitment of different epigenetic regulators to the chromatin. Here the authors provide evidence that an H3K36me3 reader PWWP2A forms a variant NuRD complex and plays a role in regulating transcription and histone
Externí odkaz:
https://doaj.org/article/5054f4fdda3244658206c728b04b321a
Autor:
Mei Han, Wenjuan Zou, Hao Chang, Yong Yu, Haining Zhang, Shitian Li, Hankui Cheng, Guifeng Wei, Yan Chen, Valerie Reinke, Tao Xu, Lijun Kang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Synaptic vesicles (SV) store various neurotransmitters that are released at the synapse. The molecular mechanisms of biogenesis, exocytosis, and endocytosis for SV, however, remain largely elusive. In this study, using Complex Object Parametric Analy
Externí odkaz:
https://doaj.org/article/6cabb0244f464ce896acd368b2d19db3