Výsledky vyhledávání

Autor: Jens Rettig, Qingning Su, Claudia Gerwin, Volker Scheuss, Sumiko Mochida, Zu-Hang Sheng, Guifang Lao

Publikováno v: Neuron. 25(1):191-201

Syntaxin-1 is a key component of the synaptic vesicle docking/fusion machinery that forms the SNARE complex with VAMP/synaptobrevin and SNAP-25. Identifying proteins that modulate SNARE complex formation is critical for understanding the molecular me

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Biomarkers for the development of new medications for cocaine dependence

Autor: Anne H. Dougherty, Kristopher J. Bough, Guifang Lao, Charles Green, Nilesh S Tannu, Joy M. Schmitz, Scott E. Hemby, Jyoti Sharma, Kyle M. Kampman, F. Gerard Moeller, Shashi Amur, Kalpana M. Merchant, Diana Martinez

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 39(1)

There has been significant progress in personalized drug development. In large part, this has taken place in the oncology field and been due to the ability of researchers/clinicians to discover and develop novel drug development tools (DDTs), such as

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https://pubmed.ncbi.nlm.nih.gov/23979119

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Cloning, sequencing, and expression of a Thermomonospora fusca protease gene in Streptomyces lividans

Autor: David Wilson, Guifang Lao

Publikováno v: Applied and Environmental Microbiology. 62:4256-4259

The major Thermomonospora fusca YX extracellular protease gene (tfpA) was cloned into Escherichia coli and Streptomyces lividans and was sequenced. The open reading frame encoded 375 residues, including a 31-residue potential signal sequence, an N-te

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https://doi.org/10.1128/aem.62.11.4256-4259.1996

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Engineering mammalian cells for solid-state sensor applications

Autor: Malcolm Potts, Paul J. Price, John R. Battista, Fredric R. Bloom, Jiu Lin Xia, Richard F. Helm, John H. Crowe, Steve Slaughter, Guifang Lao

Publikováno v: Biosensorsbioelectronics. 16(7-8)

A fundamental advance in the development and application of cell- and tissue-based biosensors would be the ability to achieve air-dry stabilization of mammalian (especially human) cells with subsequent recovery following rehydration. The would allow

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https://pubmed.ncbi.nlm.nih.gov/11544055

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Characterization of a Thermomonospora fusca exocellulase

Autor: Sheng Zhang, David Wilson, Guifang Lao

Publikováno v: Biochemistry. 34(10)

The exocellulase E3 gene was cloned on a 7.1 kb NotI fragment from Thermomonospora fusca genomic DNA into Escherichia coli and expressed in Streptomyces lividans. The E3 gene was sequenced and encoded a 596 residue peptide. The molecular masses of th

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https://pubmed.ncbi.nlm.nih.gov/7880834

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DNA sequences and expression in Streptomyces lividans of an exoglucanase gene and an endoglucanase gene from Thermomonospora fusca

Autor: Guifang Lao, David Wilson, A. Benjamin, E. D. Jung, Brian K. Barr, Diana C. Irwin

Two genes encoding cellulases E1 and E4 from Thermomonospora fusca have been cloned in Escherichia coli, and their DNA sequences have been determined. Both genes were introduced into Streptomyces lividans, and the enzymes were purified from the cultu

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https://europepmc.org/articles/PMC182403/

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