Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Guido Wendel"'
Autor:
Danmei Xu, Findlay Bewicke-Copley, Karina Close, Jessica Okosun, Robert Peter Gale, Jane Apperley, David M. Weinstock, Hans-Guido Wendel, Jude Fitzgibbon
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/091cc56248bf4dceb9867bb651ad6600
Autor:
Ana Portelinha, Mariana da Silva Ferreira, Tatiana Erazo, Man Jiang, Zahra Asgari, Elisa de Stanchina, Anas Younes, Hans-Guido Wendel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Genomic instability occurs infrequently in in diffuse large B cell lymphoma (DLBCL), suggesting a therapeutic vulnerability. Here, the authors identify a synergistic combination between the induction of polyploidy by a PLK4 inhibitor and a BCL-2 inhi
Externí odkaz:
https://doaj.org/article/10d2ea4c9cf4467884462bb93e66c548
Autor:
Susanne Schiffmann, Marina Henke, Michelle Seifert, Thomas Ulshöfer, Luise A. Roser, Francesca Magari, Hans-Guido Wendel, Arnold Grünweller, Michael J. Parnham
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5872 (2023)
A promising new approach to broad spectrum antiviral drugs is the inhibition of the eukaryotic translation initiation factor 4A (elF4A), a DEAD-box RNA helicase that effectively reduces the replication of several pathogenic virus types. Beside the an
Externí odkaz:
https://doaj.org/article/20304e90eded43f5addbbb288ee210d7
Autor:
Elisa Oricchio, Hans-Guido Wendel
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
Follicular lymphoma (FL) is an incurable form of B-cell lymphoma. Genomic alterations that inactivate RB signaling are surprisingly common in indolent FL. We show that FLs that are positive for phosphorylated RB respond to dual CDK4/BCL2 inhibition.
Externí odkaz:
https://doaj.org/article/47583e54b5f744b981a843183b968de3
Autor:
Kamini Singh, Maria Guadalupe Martinez, Jianan Lin, James Gregory, Trang Uyen Nguyen, Rawan Abdelaal, Kristy Kang, Kristen Brennand, Arnold Grünweller, Zhengqing Ouyang, Hemali Phatnani, Margaret Kielian, Hans-Guido Wendel
Publikováno v:
Viruses, Vol 14, Iss 7, p 1418 (2022)
Zika virus (ZIKV) and dengue virus (DENV) are members of the Flaviviridae family of RNA viruses and cause severe disease in humans. ZIKV and DENV share over 90% of their genome sequences, however, the clinical features of Zika and dengue infections a
Externí odkaz:
https://doaj.org/article/97db0caa53a3485ba9d516d0d9e2a0ff
Autor:
Wiebke Obermann, Alexandra Friedrich, Ramakanth Madhugiri, Paul Klemm, Jan Philipp Mengel, Torsten Hain, Stephan Pleschka, Hans-Guido Wendel, Roland K. Hartmann, Susanne Schiffmann, John Ziebuhr, Christin Müller, Arnold Grünweller
Publikováno v:
Viruses, Vol 14, Iss 3, p 519 (2022)
Rocaglates are potent broad-spectrum antiviral compounds with a promising safety profile. They inhibit viral protein synthesis for different RNA viruses by clamping the 5′-UTRs of mRNAs onto the surface of the RNA helicase eIF4A. Apart from the nat
Externí odkaz:
https://doaj.org/article/3e1d33eeeca54b6b86b42b72458da6f7
Autor:
Jibin Zhang, Tingting Wang, Kunal Shetty, Serhan Alkan, Senlin Xu, Qiang Gong, Xuxiang Liu, Yuping Li, Zunsong Hu, Wendong Huang, Hans-Guido Wendel, Alex F. Herrera, Raju K. Pillai, Joo Y. Song, Wing C. Chan
Publikováno v:
Blood Advances. 6:5067-5071
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little efficacy on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2e6eadd89b35c3fbc11103d986522f
https://doi.org/10.1158/2159-8290.c.6549037.v1
https://doi.org/10.1158/2159-8290.c.6549037.v1
Autor:
Renier J. Brentjens, Michel Sadelain, Hans-Guido Wendel, Mithat Gonen, Yvette Bernal, Daniel Li, Lisa M. DeAngelis, Xi Chen, Behroze Vachha, Hui Liu, Justin R. Cross, Terence Purdon, Brigitte Senechal, Xiuyan Wang, Elizabeth Halton, Elena Mead, Jessica Flynn, Isabelle Riviere, Darin Salloum, Jae H. Park, Bianca D. Santomasso
Table S1: Detailed descriptions of all grade neurotoxicity; Table S2: Correlation between CAR T cell phenotype and neurotoxicity; Table S3: Correlation between CSF cytokines and CSF protein concentrations; Table S4: Definitions of CRS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c8df8879a42603ffc44dc3d22f8b0e
https://doi.org/10.1158/2159-8290.22532539
https://doi.org/10.1158/2159-8290.22532539
Autor:
Ari M. Melnick, Hans-Guido Wendel, Olivier Elemento, Wayne Tam, Randy D. Gascoyne, Scott W. Hiebert, Rita Shaknovich, Robert G. Roeder, Chi-Shuen Chu, James W. Young, Sneh Sharma, Edward Holson, Janice E. Kranz, Kristy R. Stengel, David W. Scott, Daisuke Ennishi, Shenqiu Wang, David Poloway, Zhuoning Li, Cem Meydan, Matt Teater, Xabier Agirre, Ashley S. Doane, Ling Wang, Dylan McNally, Sara Parsa, Katerina Hatzi, Hsia-Yuan Ying, Huimin Geng, Ana Ortega-Molina, Yanwen Jiang
Supplementary Figure S1. Crebbp deficiency results in accelerated germinal center derived B-cell lymphoma development in mice. Supplementary Figure S2. Ep300 deficiency results in accelerated germinal center derived B-cell lymphoma development in mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454b834f82e2ea2602f9d0f040226cbc
https://doi.org/10.1158/2159-8290.22531458.v1
https://doi.org/10.1158/2159-8290.22531458.v1