Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Guido T. Bommer"'
Autor:
Joseph P. Dewulf, Manon Martin, Sandrine Marie, Fabie Oguz, Leila Belkhir, Julien De Greef, Jean Cyr Yombi, Xavier Wittebole, Pierre-François Laterre, Michel Jadoul, Laurent Gatto, Guido T. Bommer, Johann Morelle
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract SARS-CoV-2 causes major disturbances in serum metabolite levels, associated with severity of the immune response. Despite the numerous advantages of urine for biomarker discovery, the potential association between urine metabolites and disea
Externí odkaz:
https://doaj.org/article/d2faae9dc89846cf98d443222291a0d8
Publikováno v:
Microbial Cell, Vol 3, Iss 10, Pp 495-499 (2016)
Externí odkaz:
https://doaj.org/article/f68ac716a80941fba466722aa80d1a36
Autor:
Isabelle Gerin, Benoît Ury, Isabelle Breloy, Céline Bouchet-Seraphin, Jennifer Bolsée, Mathias Halbout, Julie Graff, Didier Vertommen, Giulio G. Muccioli, Nathalie Seta, Jean-Marie Cuisset, Ivana Dabaj, Susana Quijano-Roy, Ammi Grahn, Emile Van Schaftingen, Guido T. Bommer
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Mutations in genes required for the glycosylation of α-dystroglycan lead to dystroglycanopathies. Here, the authors show that three of these enzymes (ISPD, FKTN and FKRP) work together to attach ribitol phosphate to α-dystroglycan.
Externí odkaz:
https://doaj.org/article/52a41f70e28942c9b6bfb5d64d331efc
Autor:
Richard L. Watson, Aaron C. Spalding, Steven P. Zielske, Meredith Morgan, Alex C. Kim, Guido T. Bommer, Hagit Eldar-Finkelman, Thomas Giordano, Eric R. Fearon, Gary D. Hammer, Theodore S. Lawrence, Edgar Ben-Josef
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 5, Pp 357-365 (2010)
BACKGROUND: Knowledge of factors and mechanisms contributing to the inherent radioresistance of pancreatic cancer may improve cancer treatment. Irradiation inhibits glycogen synthase kinase 3β (GSK3β) by phosphorylation at serine 9. In turn, releas
Externí odkaz:
https://doaj.org/article/0f0e827a05184e858ae9e9f30ed296b7
Autor:
Manuel Johanns, Cyril Corbet, Roxane Jacobs, Melissa Drappier, Guido T. Bommer, Gaëtan Herinckx, Didier Vertommen, Nicolas Tajeddine, David Young, Joris Messens, Olivier Feron, Gregory R. Steinberg, Louis Hue, Mark H. Rider
Publikováno v:
The Biochemical journal, Vol. 479, no.12, p. 1317-1336 (2022)
Pharmacological AMPK activation represents an attractive approach for the treatment of type 2 diabetes (T2D). AMPK activation increases skeletal muscle glucose uptake, but there is controversy as to whether AMPK activation also inhibits hepatic gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aac092c3c348fbc7d9f09e908c72f48
https://doi.org/10.1042/bcj20220170
https://doi.org/10.1042/bcj20220170
Autor:
Isaac P. Heremans, Francesco Caligiore, Isabelle Gerin, Marina Bury, Marilena Lutz, Julie Graff, Vincent Stroobant, Didier Vertommen, Aurelio Teleman, Emile Van Schaftingen, Guido T. Bommer
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ce23c48e05769e258a3685735adf857
https://doi.org/10.1096/fasebj.2022.36.s1.r5062
https://doi.org/10.1096/fasebj.2022.36.s1.r5062
Autor:
Isaac P. Heremans, Francesco Caligiore, Isabelle Gerin, Marina Bury, Marilena Lutz, Julie Graff, Vincent Stroobant, Didier Vertommen, Aurelio A. Teleman, Emile Van Schaftingen, Guido T. Bommer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences USA
Proceedings of the National Academy of Sciences USA
Significance Reactive compounds cause cellular damage that is suspected to contribute to aging and neurodegenerative diseases. Oxidative stress and environmental factors likely contribute to this. Here we report that an enzyme mutated in Parkinson’
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed33e9ff7ec2860c4048d4b0ee54198
http://europepmc.org/articles/PMC8795555
http://europepmc.org/articles/PMC8795555
Publikováno v:
Journal of Inherited Metabolic Disease
It is traditionally assumed that enzymes of intermediary metabolism are extremely specific and that this is sufficient to prevent the production of useless and/or toxic side‐products. Recent work indicates that this statement is not entirely correc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea45d9ed6879fd3fb9480906f71a758
https://doi.org/10.1002/jimd.12187
https://doi.org/10.1002/jimd.12187
Autor:
Younes Achouri, Joseph P. Dewulf, Emile Van Schaftingen, Stéphanie Paquay, Etienne Marbaix, Guido T. Bommer
Publikováno v:
The Journal of Biological Chemistry
The Journal of biological chemistry, Vol. 297, no.4, p. 101083 (2021)
The Journal of biological chemistry, Vol. 297, no.4, p. 101083 (2021)
The cytosolic enzyme ethylmalonyl-CoA decarboxylase (ECHDC1) decarboxylates ethyl- or methyl-malonyl-CoA, two side-products of acetyl-CoA carboxylase. These CoA derivatives can be used to synthesize a subset of branched-chain fatty acids (FAs). We pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b97fc024070caa6e86136ac1563a523
https://pubmed.ncbi.nlm.nih.gov/34419447
https://pubmed.ncbi.nlm.nih.gov/34419447
Autor:
Guido T. Bommer, Isabelle Gerin, Maria Veiga-da-Cunha, Mark H. Rider, Joseph P. Dewulf, Emile Van Schaftingen
Publikováno v:
Biochemical Journal
The Biochemical journal, Vol. 476, no. 16, p. 2427-2447 (2019)
The Biochemical journal, Vol. 476, no. 16, p. 2427-2447 (2019)
Most fatty acids (FAs) are straight chains and are synthesized by fatty acid synthase (FASN) using acetyl-CoA and malonyl-CoA units. Yet, FASN is known to be promiscuous as it may use methylmalonyl-CoA instead of malonyl-CoA and thereby introduce met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b04f64548f63bda73e0b47bba8c527d
https://doi.org/10.1042/bcj20190500
https://doi.org/10.1042/bcj20190500