Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Guido R. M. M. Haenen"'
Autor:
Yaping Xu, Yue Wang, Chujie Li, Tao Han, Haiming Chen, Wenxue Chen, Qiuping Zhong, Jianfei Pei, Guido R. M. M. Haenen, Zhengwen Li, Mohamed Moalin, Ming Zhang, Weijun Chen
Publikováno v:
AAPS Open, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Dihydroquercetin (DHQ) is a natural occurring dihydroflavonol that has strong antioxidant and antibacterial activities. However, its application is limited due to its poor solubility. This study aims to improve the aqueous solubility of DHQ
Externí odkaz:
https://doaj.org/article/fef7384b379345a3a32cefc155631980
Autor:
Yaping Xu, Zhengwen Li, Yue Wang, Chujie Li, Ming Zhang, Haiming Chen, Wenxue Chen, Qiuping Zhong, Jianfei Pei, Weijun Chen, Guido R. M. M. Haenen, Mohamed Moalin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14220 (2023)
It has been reported that in an oxidative environment, the flavonoid 2R,3R-dihydroquercetin (2R,3R-DHQ) oxidizes into a product that rearranges to form quercetin. As quercetin is a very potent antioxidant, much better than 2R,3R-DHQ, this would be an
Externí odkaz:
https://doaj.org/article/2da7dfb94298416887548f276fac29ba
Autor:
Guido R. M. M. Haenen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6667 (2023)
‘Forever’ chemicals that unintendedly in the long run pollute the environment, climate change, COVID; life continuously faces all sorts of unforeseen challenges that are an inevitable side product of ‘progress’ [...]
Externí odkaz:
https://doaj.org/article/e4fba4b4ce8741cb89f84bb9b7241cf8
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 187 (2021)
In all life forms, opposing forces provide the energy that flows through networks in an organism, which fuels life. In this concept, health is the ability of an organism to maintain the balance between these opposing forces, which creates resilience,
Externí odkaz:
https://doaj.org/article/860ee394e5ad44989cc5f647bd927940
Autor:
Zhengwen Li, Mohamed Moalin, Ming Zhang, Lily Vervoort, Erik Hursel, Alex Mommers, Guido R. M. M. Haenen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6015 (2020)
Most studies on the antioxidant activity of flavonoids like Quercetin (Q) do not consider that it comprises a series of sequential reactions. Therefore, the present study examines how the redox energy flows through the molecule during Q’s antioxida
Externí odkaz:
https://doaj.org/article/0dd113c3d5994a8f81f90222ed76ab5a
Autor:
Kristien J. A. Lemmens, Misha F. Vrolijk, Freek G. Bouwman, Wim J. F. van der Vijgh, Aalt Bast, Guido R. M. M. Haenen
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 5, Pp 7475-7484 (2014)
Antioxidants act as intermediates by picking up the high unselective reactivity of radicals and transferring it to other molecules. In this process the reactivity is reduced and becomes selective. This channeling of the reactivity can cause selective
Externí odkaz:
https://doaj.org/article/f84e6feec60d4b628f9e1a1b3c8c2d42
Autor:
Guido R. M. M. Haenen, Aalt Bast, Paul J. Borm, Geja J. Hagemen, Maud Beckers, Gino P. F. van Strijdonck, Mohamed Moalin
Publikováno v:
Molecules, Vol 16, Iss 11, Pp 9636-9650 (2011)
The polyphenol quercetin (Q) that has a high antioxidant capacity is a lead compound in the design of antioxidants. We investigated the possibility of modifying quercetin while retaining its antioxidant capacity as much as possible. To this end, the
Externí odkaz:
https://doaj.org/article/d9da1f19096f476f9397f0771c210a6f
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 1, p 18 (2017)
Many Western drugs can give rise to serious side effects due to their ability to bind to acetylcholine receptors in the brain. This aggravates when they are combined, which is known as anticholinergic accumulation (AA). Some bioactives in Traditional
Externí odkaz:
https://doaj.org/article/2f267a8109294b9ab58ff6a801f36631
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 10, p 1649 (2016)
Life on Earth has to adapt to the ever changing environment. For example, due to introduction of oxygen in the atmosphere, an antioxidant network evolved to cope with the exposure to oxygen. The adaptive mechanisms of the antioxidant network, specifi
Externí odkaz:
https://doaj.org/article/b4311ba1f83548a686988065cbc232fc
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 2, p 239 (2016)
In chronic inflammatory diseases the anti-inflammatory effect of glucocorticoids (GCs) is often decreased, leading to GC resistance. Inflammation is related with increased levels of reactive oxygen species (ROS), leading to oxidative stress which is
Externí odkaz:
https://doaj.org/article/50ed3128631346528b515f04c4b26cfc