Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Guido P. L. Bossers"'
Autor:
Quint A. J. Hagdorn, Kondababu Kurakula, Anne-Marie C. Koop, Guido P. L. Bossers, Emmanouil Mavrogiannis, Tom van Leusden, Diederik E. van der Feen, Rudolf A. de Boer, Marie-José T. H. Goumans, Rolf M. F. Berger
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundRight ventricular (RV) function and failure are key determinants of morbidity and mortality in various cardiovascular diseases. Myocardial fibrosis is regarded as a contributing factor to heart failure, but its importance in RV failure has
Externí odkaz:
https://doaj.org/article/59a9886305c849eb969d7513d719491a
Autor:
Anne‐Marie C. Koop, Guido P. L. Bossers, Mark‐Jan Ploegstra, Quint A. J. Hagdorn, Rolf M. F. Berger, Herman H. W. Silljé, Beatrijs Bartelds
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 21 (2019)
Background Right ventricular (RV) failure because of chronic pressure load is an important determinant of outcome in pulmonary hypertension. Progression towards RV failure is characterized by diastolic dysfunction, fibrosis and metabolic dysregulatio
Externí odkaz:
https://doaj.org/article/cbe97ece7971434b9af7d9df7a8c2354
Autor:
Guido P. L. Bossers, Quint A. J. Hagdorn, Anne-Marie C. Koop, Diederik E. van der Feen, B. Bartelds, Tom van Leusden, Rudolf A. De Boer, Herman H. W. Silljé, Rolf M. F. Berger
Publikováno v:
American journal of physiology. Heart and circulatory physiology, 322(6), H994-H1002. American Physiological Society
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 322(6), H994-H1002. AMER PHYSIOLOGICAL SOC
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 322(6), H994-H1002. AMER PHYSIOLOGICAL SOC
Sex is increasingly emerging as determinant of right ventricular (RV) adaptation to abnormal loading conditions. It is unknown, however, whether sex-related differences already occur in childhood. Therefore, this study aimed to assess sex differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0c4f01d37eccea3b9ee48de53fb5fc
https://pure.eur.nl/en/publications/8006ea05-4b59-4606-8f94-166c06cfb9a5
https://pure.eur.nl/en/publications/8006ea05-4b59-4606-8f94-166c06cfb9a5
Autor:
M. van Weeghel, Beatrijs Bartelds, Frédéric M. Vaz, Rolf M. F. Berger, Quint A. J. Hagdorn, Anne-Marie C. Koop, A. Gerding, T. van Leusden, Debby P.Y. Koonen, Herman H W Silljé, Guido P. L. Bossers
Publikováno v:
International Journal of Cardiology, 287, 96-105. ELSEVIER IRELAND LTD
International journal of cardiology, 287, 96-105. Elsevier Ireland Ltd
International journal of cardiology, 287, 96-105. Elsevier Ireland Ltd
Introduction: Right ventricular (RV) failure due to pressure load is an important determinant of clinical outcome in pulmonary hypertension, congenital heart disease and left ventricular failure. The last decades it has become clear that metabolic dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df58413d2855b7bb2e6432441f21ae43
https://doi.org/10.1016/j.ijcard.2019.04.004
https://doi.org/10.1016/j.ijcard.2019.04.004
Autor:
Rudolf A. de Boer, Kondababu Kurakula, Anne-Marie C. Koop, Marie-José Goumans, Guido P. L. Bossers, Rolf M. F. Berger, Diederik E. van der Feen, Emmanouil Mavrogiannis, Tom van Leusden, Quint A. J. Hagdorn
Publikováno v:
Frontiers in Physiology, 12:557514. Frontiers Media SA
Frontiers in Physiology, 12. FRONTIERS MEDIA SA
Frontiers in Physiology, 12:557514. Frontiers Research Topics
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Hagdorn, Q A J, Kurakula, K, Koop, A M C, Bossers, G P L, Mavrogiannis, E, van Leusden, T, van der Feen, D E, de Boer, R A, Goumans, M J T H & Berger, R M F 2021, ' Volume Load-Induced Right Ventricular Failure in Rats Is Not Associated With Myocardial Fibrosis ', Frontiers in Physiology, vol. 12, 557514, pp. 557514 . https://doi.org/10.3389/fphys.2021.557514, https://doi.org/10.3389/fphys.2021.557514
Frontiers in Physiology, 12. FRONTIERS MEDIA SA
Frontiers in Physiology, 12:557514. Frontiers Research Topics
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Hagdorn, Q A J, Kurakula, K, Koop, A M C, Bossers, G P L, Mavrogiannis, E, van Leusden, T, van der Feen, D E, de Boer, R A, Goumans, M J T H & Berger, R M F 2021, ' Volume Load-Induced Right Ventricular Failure in Rats Is Not Associated With Myocardial Fibrosis ', Frontiers in Physiology, vol. 12, 557514, pp. 557514 . https://doi.org/10.3389/fphys.2021.557514, https://doi.org/10.3389/fphys.2021.557514
BackgroundRight ventricular (RV) function and failure are key determinants of morbidity and mortality in various cardiovascular diseases. Myocardial fibrosis is regarded as a contributing factor to heart failure, but its importance in RV failure has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0926a4d88e28ffc2253ab8ec419bd45d
https://research.rug.nl/en/publications/293cd841-afd7-4c05-879c-617892f6fedc
https://research.rug.nl/en/publications/293cd841-afd7-4c05-879c-617892f6fedc
Autor:
Quint A. J. Hagdorn, Rolf M. F. Berger, Guido P. L. Bossers, Anne-Marie C. Koop, Karel van Duijvenboden, Marie Günthel Dipl-Ing, Marinus A.J. Borgdorff, Vincent M. Christoffels, Herman H W Silljé, Phil Barnett, Beatrijs Bartelds, Diederik E. van der Feen
Publikováno v:
Journal of thoracic and cardiovascular surgery. Mosby Inc.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 164(6), e493-e510. MOSBY-ELSEVIER
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 164(6), e493-e510. MOSBY-ELSEVIER
OBJECTIVES: Right ventricular (RV) failure is a leading cause of death in patients with congenital heart disease. RV failure is kept at bay during childhood. Limited proliferation of cardiomyocytes is present in the postnatal heart. We propose that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b03648597bc7b1fc0cecc7e91c4a3f
https://pure.amc.nl/en/publications/neuregulin1-enhances-cellcycle-activity-delays-cardiac-fibrosis-and-improves-cardiac-performance-in-rat-pups-with-right-ventricular-pressure-load(57fcd891-8b23-48ba-bdfd-62b5017ecaa1).html
https://pure.amc.nl/en/publications/neuregulin1-enhances-cellcycle-activity-delays-cardiac-fibrosis-and-improves-cardiac-performance-in-rat-pups-with-right-ventricular-pressure-load(57fcd891-8b23-48ba-bdfd-62b5017ecaa1).html
Autor:
Arjen H. Petersen, Rudolf A. de Boer, Diederik E. van der Feen, Rolf M. F. Berger, Marco Demaria, Michele Donato, Purvesh Khatri, Jaskaren Kohli, Guido P. L. Bossers, Francesco Vallania, Beatrijs Bartelds, Marlene Rabinovitch, Robert Szulcek, James Chappell, Klaas Kok, Tom van Leusden, Quint A. J. Hagdorn, Kondababu Kurakula, Marie-José Goumans, Jan-Renier A. J. Moonen
Publikováno v:
Sci Transl Med
Science Translational Medicine, 12(554):eaaw4974. American Association for the Advancement of Science
van der Feen, D E, Bossers, G P L, Hagdorn, Q A J, Moonen, J R, Kurakula, K, Szulcek, R, Chappell, J, Vallania, F, Donato, M, Kok, K, Kohli, J S, Petersen, A H, van Leusden, T, Demaria, M, Goumans, M J T H, De Boer, R A, Khatri, P, Rabinovitch, M, Berger, R M F & Bartelds, B 2020, ' Cellular senescence impairs the reversibility of pulmonary arterial hypertension ', Science Translational Medicine, vol. 12, no. 554, eaaw4974 . https://doi.org/10.1126/scitranslmed.aaw4974
Science Translational Medicine, 12(554). AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine, 12(554):4974. AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine, 12(554):eaaw4974. American Association for the Advancement of Science
van der Feen, D E, Bossers, G P L, Hagdorn, Q A J, Moonen, J R, Kurakula, K, Szulcek, R, Chappell, J, Vallania, F, Donato, M, Kok, K, Kohli, J S, Petersen, A H, van Leusden, T, Demaria, M, Goumans, M J T H, De Boer, R A, Khatri, P, Rabinovitch, M, Berger, R M F & Bartelds, B 2020, ' Cellular senescence impairs the reversibility of pulmonary arterial hypertension ', Science Translational Medicine, vol. 12, no. 554, eaaw4974 . https://doi.org/10.1126/scitranslmed.aaw4974
Science Translational Medicine, 12(554). AMER ASSOC ADVANCEMENT SCIENCE
Science Translational Medicine, 12(554):4974. AMER ASSOC ADVANCEMENT SCIENCE
Pulmonary arterial hypertension (PAH) in congenital cardiac shunts can be reversed by hemodynamic unloading (HU) through shunt closure. However, this reversibility potential is lost beyond a certain point in time. The reason why PAH becomes irreversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53fdf3bcfa519e3f48fa15309750ee9
https://europepmc.org/articles/PMC7891555/
https://europepmc.org/articles/PMC7891555/
Autor:
Beatrijs Bartelds, Herman H W Silljé, Mark-Jan Ploegstra, Rolf M. F. Berger, Marinus A.J. Borgdorff, Guido P. L. Bossers, Quint A. J. Hagdorn
Publikováno v:
European Journal of Heart Failure. 20:808-812
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d978568c0423136b1ad4031e4aaafe4
https://doi.org/10.1002/ejhf.931
https://doi.org/10.1002/ejhf.931
Autor:
Guido P. L. Bossers, Mark-Jan Ploegstra, Rolf M. F. Berger, Anne-Marie C. Koop, Beatrijs Bartelds, Quint A. J. Hagdorn, Herman H W Silljé
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, 8(21):e012086. Wiley
Journal of the American Heart Association, 8(21):e012086. Wiley
Background Right ventricular ( RV ) failure because of chronic pressure load is an important determinant of outcome in pulmonary hypertension. Progression towards RV failure is characterized by diastolic dysfunction, fibrosis and metabolic dysregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c244693bd157b75df7b95302a0db4f
https://pubmed.ncbi.nlm.nih.gov/31657265
https://pubmed.ncbi.nlm.nih.gov/31657265
Autor:
Karima Habbout, Ravi Jahagirdar, Guido P. L. Bossers, Sandra Martineau, Roxane Paulin, Beatrijs Bartelds, Robert Szulcek, Marie-Claude Lampron, Marie-José Goumans, Alice Bourgeois, Rolf M. F. Berger, Diederik E. van der Feen, Eve Tremblay, Ingrid Schalij, Ewelina Kulikowski, Olivier Boucherat, Steeve Provencher, Harm Jan Bogaard, Kondababu Kurakula, Sébastien Bonnet
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 200(7), 910-920. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine, 200(7), 910-920. AMER THORACIC SOC
Van der Feen, D E, Kurakula, K, Tremblay, E, Boucherat, O, Bossers, G PL, Szulcek, R, Bourgeois, A, Lampron, M-C, Habbout, K, Martineau, S, Paulin, R, Kulikowski, E, Jahagirdar, R, Schalij, I, Bogaard, H J, Bartelds, B, Provencher, S, Berger, R M F, Bonnet, S & Goumans, M-J 2019, ' Multicenter preclinical validation of BET inhibition for the treatment of pulmonary arterial hypertension ', American Journal of Respiratory and Critical Care Medicine, vol. 200, no. 7, pp. 910-920 . https://doi.org/10.1164/rccm.201812-2275OC, https://doi.org/10.1164/rccm.201812-2275OC
American Journal of Respiratory and Critical Care Medicine, 200(7), 910-920. AMER THORACIC SOC
Van der Feen, D E, Kurakula, K, Tremblay, E, Boucherat, O, Bossers, G PL, Szulcek, R, Bourgeois, A, Lampron, M-C, Habbout, K, Martineau, S, Paulin, R, Kulikowski, E, Jahagirdar, R, Schalij, I, Bogaard, H J, Bartelds, B, Provencher, S, Berger, R M F, Bonnet, S & Goumans, M-J 2019, ' Multicenter preclinical validation of BET inhibition for the treatment of pulmonary arterial hypertension ', American Journal of Respiratory and Critical Care Medicine, vol. 200, no. 7, pp. 910-920 . https://doi.org/10.1164/rccm.201812-2275OC, https://doi.org/10.1164/rccm.201812-2275OC
Rationale: Pulmonary arterial hypertension (PAH) is a degenerative arteriopathy that leads to right ventricular (RV) failure. BRD4 (bromodomain-containing protein 4), a member of the BET (bromodomain and extra-terminal motif) family, has been identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1080444cf954254efa11ac9596014acf
https://research.vumc.nl/en/publications/05a0fffc-21eb-4c2c-8b59-541f22c7d740
https://research.vumc.nl/en/publications/05a0fffc-21eb-4c2c-8b59-541f22c7d740