Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Guido Kurz"'
Autor:
Esperanza Martín-Sánchez, Socorro M. Rodríguez-Pinilla, Margarita Sánchez-Beato, Luis Lombardía, Beatriz Domínguez-González, Diana Romero, Lina Odqvist, Pablo García-Sanz, Magdalena B. Wozniak, Guido Kurz, Carmen Blanco-Aparicio, Manuela Mollejo, F. Javier Alves, Javier Menárguez, Fernando González-Palacios, José Luis Rodríguez-Peralto, Pablo L. Ortiz-Romero, Juan F. García, James R. Bischoff, Miguel A. Piris
Publikováno v:
Haematologica, Vol 98, Iss 1 (2013)
Peripheral T-cell lymphomas are very aggressive hematologic malignancies for which there is no targeted therapy. New, rational approaches are necessary to improve the very poor outcome in these patients. Phosphatidylinositol-3-kinase is one of the mo
Externí odkaz:
https://doaj.org/article/14db3811599b4511a95671c0d27c5ee4
Autor:
Gustavo Saluste, Maria I Albarran, Rosa M Alvarez, Obdulia Rabal, Miguel Angel Ortega, Carmen Blanco, Guido Kurz, Antonio Salgado, Paolo Pevarello, James R Bischoff, Joaquin Pastor, Julen Oyarzabal
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45964 (2012)
A new chemical series, triazolo[4,5-b]pyridines, has been identified as an inhibitor of PIM-1 by a chemotype hopping strategy based on a chemically feasible fragment database. In this case, structure-based virtual screening and in silico chemogenomic
Externí odkaz:
https://doaj.org/article/1991fa60141b408181e69602e550bc26
Autor:
Daniel H. Wiseman, Julio Cesar Castro-Palomino, Christophe Willekens, Iñigo Tirapu, Alberto Ortega, Cristina Mascaró, Filippo Ciceri, Guido Kurz, Nathalie Guibourt, Marc Martinell, Cihangir Duy, Nuria Valls, Carlos Buesa, Angels Estiarte, Ari Melnick, Tamara Maes, Michele M.P. Lufino, Tim C. P. Somervaille, Alvaro Perdones, Matthew Colin Thor Fyfe, Serena Lunardi
Publikováno v:
Cancer cell. 33(3)
Summary The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf894e7653b94c6547fc85d60ea372c
https://pubmed.ncbi.nlm.nih.gov/29533778
https://pubmed.ncbi.nlm.nih.gov/29533778
Autor:
Pablo Garcia-Sanz, James R. Bischoff, Lina Odqvist, Esperanza Martín-Sánchez, Manuela Mollejo, Margarita Sánchez-Beato, F. Javier Alves, José Luis Rodríguez-Peralto, Javier Menárguez, Magdalena B. Wozniak, Carmen Blanco-Aparicio, Pablo L. Ortiz-Romero, Diana Romero, Socorro María Rodríguez-Pinilla, Luis Lombardia, Beatriz Dominguez-Gonzalez, Juan F. García, Guido Kurz, Fernando González-Palacios, Miguel A. Piris
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
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Obtained from Haematologica/the Hematology Journal website http://www.haematologica.org
Peripheral T-cell lymphomas are very aggressive hematologic malignancies for which there is no targeted therapy. New, rational approaches are necessary to im
Peripheral T-cell lymphomas are very aggressive hematologic malignancies for which there is no targeted therapy. New, rational approaches are necessary to im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79fd3792560d9bc40e0a6009dedc486
https://hdl.handle.net/10486/662805
https://hdl.handle.net/10486/662805
Autor:
Guido Kurz, James R. Bischoff, Miguel Angel Ortega, Joaquín Pastor, Julen Oyarzabal, Carmen Blanco, María Isabel Albarrán, Antonio Salgado, Paolo Pevarello, Obdulia Rabal, Rosa María Alvarez, Gustavo Saluste
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e45964 (2012)
PLoS ONE, Vol 7, Iss 10, p e45964 (2012)
A new chemical series, triazolo[4,5-b]pyridines, has been identified as an inhibitor of PIM-1 by a chemotype hopping strategy based on a chemically feasible fragment database. In this case, structure-based virtual screening and in silico chemogenomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695da6466de38b333cf5b8c938ba0c24
http://europepmc.org/articles/PMC3480357
http://europepmc.org/articles/PMC3480357
Autor:
Paolo Pevarello, Milagros Lorenzo, Teresa G. Granda, David Soilan, Sandra Peregrina, María Isabel Albarrán, Obdulia Rabal, Amancio Carnero, Beatriz G. Serelde, Patricia Alfonso, Antonio Cebriá, Plácido A. Ceballos, Julen Oyarzabal, Jesús Fominaya, Ana-Isabel Hernández, James R. Bischoff, Wolfgang Link, Guido Kurz, Oliver Renner
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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9 páginas, 4 figuras, 1 tabla.
Activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is one the most frequent genetic events in human cancer. A cell-based imaging assay that monitored the translocation of the Akt effector pro
Activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is one the most frequent genetic events in human cancer. A cell-based imaging assay that monitored the translocation of the Akt effector pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0dc98bcd67fa063d8869121bed1dd17
http://hdl.handle.net/10261/38823
http://hdl.handle.net/10261/38823
Autor:
Rolf Olsson, Charlotta Häggström, Lars O. M. Engblom, Guido Kurz, Vivienne Larwood, Kent Axelsson, Naimie H. M. Edling, Birgitta Ohman, Tjeerd Barf, Yuko Rönquist-Nii, Lars Abrahmsén, Rikard Emond, Erifili Mosialou, Alf Nygren, Jerk Vallgarda, Peteris Alberts
Publikováno v:
Journal of medicinal chemistry. 45(18)
Novel antidiabetic arylsulfonamidothiazoles are presented that exert action through selective inhibition of the 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme, thereby attenuating hepatic gluconeogenesis. The diethylamide derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcca58273d3a2ee8afca1d47a6720349
https://pubmed.ncbi.nlm.nih.gov/12190302
https://pubmed.ncbi.nlm.nih.gov/12190302
Autor:
S. Martinez, A. Cebria, Guido Kurz, M.R. Rico Ferreira, I. Palacios, J. Pastor, J.R. Bischoff, D. Soilan, O. Rabal, M.A. Ortega
Publikováno v:
European Journal of Cancer Supplements. 8:25-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2d12a6f5f37d854ca09b028e684927d
https://doi.org/10.1016/s1359-6349(10)71757-2
https://doi.org/10.1016/s1359-6349(10)71757-2
Autor:
Hans-Jürgen Diehl, Guido Kurz, Matthias Köck, Hans Matter, Horst Kessler, Mia Callens, Rik K. Wierenga, Armin Geyer, Fred R. Opperdoes
Publikováno v:
Angewandte Chemie. 104:343-345
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f38a1c8f1ff9aa8b3fce73478557d9f
https://doi.org/10.1002/ange.19921040331
https://doi.org/10.1002/ange.19921040331
Autor:
Matthias Köck, Armin Geyer, Guido Kurz, Hans Matter, Hans-Jürgen Diehl, Fred R. Opperdoes, Horst Kessler, Rik K. Wierenga, Mia Callens
Publikováno v:
Angewandte Chemie International Edition in English. 31:328-330
One approach to conquering sleeping sickness is the selective inhibition of trypanosomal triosephosphate isomerase, a key enzyme in the pathogen's metabolism, with cyclic hexapeptides. The thionylation of the Phe5-Phe6 amide bond of the cyclic hexape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ab55edb451fe4386872af57fd40f3df
https://doi.org/10.1002/anie.199203281
https://doi.org/10.1002/anie.199203281