Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Guido Koch"'
Publikováno v:
CHIMIA, Vol 74, Iss 10, Pp 814-817 (2020)
Chronic non-healing wounds impose a huge burden on patients and health care providers. In spite of improvements in standards of care there are no effective and safe treatments that promote new tissue formation and wound closure in ailments such as di
Externí odkaz:
https://doaj.org/article/c530af13c9ab4af5b54bef6a97aac416
Publikováno v:
CHIMIA, Vol 74, Iss 10 (2020)
Externí odkaz:
https://doaj.org/article/60e9988563364203890e3ac99e611412
Autor:
Guido Koch
Publikováno v:
CHIMIA, Vol 71, Iss 10 (2017)
Externí odkaz:
https://doaj.org/article/a0ae7c26fa4e43fe9e445a939a790f87
Publikováno v:
CHIMIA, Vol 57, Iss 5 (2003)
The core structure of a natural product was selected as scaffold for combinatorial library synthesis. The key step for the construction of the 3,9-diazabicyclo[3.3.1]non-6-ene core is a novel Dakin-West/Pictet-Spengler reaction sequence. Route select
Externí odkaz:
https://doaj.org/article/9e86f75ca86c435b92e6287ef7b3b734
Autor:
Heiner Schuetz, Anthony Casarez, Robert Lowell Simmons, Folkert Reck, Guido Koch, Sandro Nocito, Markus Furegati
Publikováno v:
Organic Process Research & Development. 24:1244-1253
The new potentially best-in-class β-lactamase inhibitor IID572 was discovered by a late-stage functionalization approach. An alternative synthesis was developed to satisfy the short-term material n...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37d655d0da596bb5d51f4b26e284c044
https://doi.org/10.1021/acs.oprd.0c00069
https://doi.org/10.1021/acs.oprd.0c00069
Autor:
Thomas Vorherr, Marcel Leroux, Michael Schaefer, Paul Knochel, Ian Lewis, Konstantin Karaghiosoff, Guido Koch
Publikováno v:
Angewandte Chemie International Edition. 58:8231-8234
We have reported a new late-stage functionalization of small peptides and cyclopeptides using readily prepared iodotyrosine or iodophenylalanine containing peptides and performing Negishi cross-couplings with aryl-, heteroaryl- and alkyl-zinc pivalat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edaa68fa723dcdd9b87addab93eacd8
https://doi.org/10.1002/anie.201902454
https://doi.org/10.1002/anie.201902454
Autor:
Paul Knochel, Thomas Vorherr, Konstantin Karaghiosoff, Ian Lewis, Marcel Leroux, Guido Koch, Michael Schaefer
Publikováno v:
Angewandte Chemie. 131:8316-8320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6ab9c54ad86c37c3345f1ce69306ec
https://doi.org/10.1002/ange.201902454
https://doi.org/10.1002/ange.201902454
Publikováno v:
CHIMIA, Vol 74, Iss 10, Pp 814-817 (2020)
Chronic non-healing wounds impose a huge burden on patients and health care providers. In spite of improvements in standards of care there are no effective and safe treatments that promote new tissue formation and wound closure in ailments such as di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4174f29b7078fb7d6887a9ec5cde7c4
https://pubmed.ncbi.nlm.nih.gov/33115566
https://pubmed.ncbi.nlm.nih.gov/33115566
Publikováno v:
Angewandte Chemie. 129:12949-12953
We report a general preparation of arylated bicyclo[1.1.1]pentanes by the opening of [1.1.1]propellane with various arylmagnesium halides. After transmetalation with ZnCl2 and a Negishi cross-coupling with aryl and heteroaryl halides, bis-arylated bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fa410eaa2e105c5fb174df3f7896052
https://doi.org/10.1002/ange.201706799
https://doi.org/10.1002/ange.201706799
Publikováno v:
Synlett. 28:1636-1640
The paper demonstrates a safe method in which highly unstable O-mesitylsulfonylhydroxylamine (MSH) can be prepared and consumed in continuous flow. MSH was prepared in situ and used for the flow amination of a range of pyridines, which were subsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66dffe0fd8c55011063deb45f8079bfd
https://doi.org/10.1055/s-0036-1588799
https://doi.org/10.1055/s-0036-1588799