Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Guido Keijzers"'
Autor:
Artur Wnorowski, Danuta Dudzik, Michel Bernier, Jakub Wójcik, Guido Keijzers, Alberto Diaz-Ruiz, Karolina Mazur, Yongqing Zhang, Haiyong Han, Morten Scheibye-Knudsen, Krzysztof Jozwiak, Coral Barbas, Irving W. Wainer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Metabolic reprogramming contributes to oncogenesis, tumor growth, and treatment resistance in pancreatic ductal adenocarcinoma (PDAC). Here we report the effects of (R,S′)-4′-methoxy-1-naphthylfenoterol (MNF), a GPR55 antagonist and bias
Externí odkaz:
https://doaj.org/article/ab585d3344ff410ab9d0f234f371e331
Autor:
Jon Ambæk Durhuus, Maarten P. Rozing, Marie Krogh Nielsen, Christopher Rue Molbech, Guido Keijzers, Morten Scheibye-Knudsen, Lene Juel Rasmussen, Rudi G. J. Westendorp, Torben Lykke Sørensen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Age-related macular degeneration (AMD) is a highly prevalent degenerative disease and a leading cause of vision loss worldwide. Evidence for an inflammatory component in the development of AMD exists, yet the exact mechanisms remain unclear.
Externí odkaz:
https://doaj.org/article/90a31db0e9514fae98b0ee165a94d82a
Autor:
Peng Song, Shaojun Liu, Dekang Liu, Guido Keijzers, Daniela Bakula, Shunlei Duan, Niels de Wind, Zilu Ye, Sergey Y. Vakhrushev, Morten Scheibye-Knudsen, Lene Juel Rasmussen
Publikováno v:
Cells, Vol 11, Iss 3, p 521 (2022)
DNA mismatch repair (MMR) is a highly conserved pathway that corrects both base–base mispairs and insertion-deletion loops (IDLs) generated during DNA replication. Defects in MMR have been linked to carcinogenesis and drug resistance. However, the
Externí odkaz:
https://doaj.org/article/ee9708c0af6a4ec8b6d76963285d4ab2
Autor:
Huiming Lu, Raghavendra A. Shamanna, Guido Keijzers, Roopesh Anand, Lene Juel Rasmussen, Petr Cejka, Deborah L. Croteau, Vilhelm A. Bohr
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 161-173 (2016)
The RecQ helicase RECQL4, mutated in Rothmund-Thomson syndrome, regulates genome stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end resection, which is the initial and an essential step of homologous recombination (H
Externí odkaz:
https://doaj.org/article/ed1c1ede51e940ae8554082a50f5dfce
Autor:
Takabumi Inagawa, Thomas Wennink, Joyce H. G. Lebbink, Guido Keijzers, Bogdan I. Florea, Nicole S. Verkaik, Dik C. van Gent
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6725 (2020)
The Ku70/80 heterodimer binds to DNA ends and attracts other proteins involved in the non-homologous end-joining (NHEJ) pathway of DNA double-strand break repair. We developed a novel assay to measure DNA binding and release kinetics using difference
Externí odkaz:
https://doaj.org/article/9670f73492094ca9b33adf6639a4513c
Autor:
Guido Keijzers, Daniela Bakula, Michael Angelo Petr, Nils Gedsig Kirkelund Madsen, Amanuel Teklu, Garik Mkrtchyan, Brenna Osborne, Morten Scheibye-Knudsen
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 1, p 74 (2018)
Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or
Externí odkaz:
https://doaj.org/article/ad0adba4ca4642a1bba6e94308d1a904
Autor:
Michael Angelo Petr, Lina M Carmona-Marin, Tulika Tulika, Stella Kristensen, Simon Reves, Daniela Bakula, Guido Keijzers, Brenna Osborne, Sarah J Mitchell, Sam Hamilton, Jonathan Kato, Irene Alfaras, Amanuel A. Teklu, Indra Heckenbach, Jakob Madsen, Michael Ben Ezra, Garik Mkrtchyan, Erika Varner, Benjamin Fink, Eliana von Krusenstiern, Nathaniel W Snyder, Hector Herranz, Rafael de Cabo, Morten Scheibye-Knudsen
SUMMARYThere is currently no established intervention for Cockayne syndrome, a disease characterized by progressive early onset neurodegeneration with features of premature aging. Here, we tested if acetyl-CoA precursors, citrate and beta-hydroxybuty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cd60a3aee6463049e9191d2cb534bb5
https://doi.org/10.1101/2022.03.08.483430
https://doi.org/10.1101/2022.03.08.483430
Autor:
Peng Song, Shaojun Liu, Dekang Liu, Guido Keijzers, Daniela Bakula, Shunlei Duan, Niels de Wind, Zilu Ye, Sergey Y. Vakhrushev, Morten Scheibye-Knudsen, Lene Juel Rasmussen
Publikováno v:
Cells, Vol 11, Iss 521, p 521 (2022)
Cells; Volume 11; Issue 3; Pages: 521
Cells, 11(3). MDPI
Song, P, Liu, S, Liu, D, Keijzers, G, Bakula, D, Duan, S, de Wind, N, Ye, Z, Vakhrushev, S Y, Scheibye-Knudsen, M & Rasmussen, L J 2022, ' CNOT6 : A Novel Regulator of DNA Mismatch Repair ', Cells, vol. 11, no. 3, 521 . https://doi.org/10.3390/cells11030521
Cells; Volume 11; Issue 3; Pages: 521
Cells, 11(3). MDPI
Song, P, Liu, S, Liu, D, Keijzers, G, Bakula, D, Duan, S, de Wind, N, Ye, Z, Vakhrushev, S Y, Scheibye-Knudsen, M & Rasmussen, L J 2022, ' CNOT6 : A Novel Regulator of DNA Mismatch Repair ', Cells, vol. 11, no. 3, 521 . https://doi.org/10.3390/cells11030521
DNA mismatch repair (MMR) is a highly conserved pathway that corrects both base–base mispairs and insertion-deletion loops (IDLs) generated during DNA replication. Defects in MMR have been linked to carcinogenesis and drug resistance. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2c0b6a071d4479f463ea7ebb73557e
https://hdl.handle.net/1887/3564228
https://hdl.handle.net/1887/3564228
Autor:
Dylan M. Glubb, Niels de Wind, Helga Westers, Christi J. van Asperen, Marc S. Greenblatt, Susan S. Wallace, Lisa Pappas, Scott D. Kathe, Sean V. Tavtigian, Rolf H. Sijmons, David E. Goldgar, Jane H. Frederiksen, Kenneth M. Boucher, Guido Keijzers, Bryony A. Thompson, Yvonne Tiersma, Mark Drost, Jan Osinga, José B. M. Zonneveld, Siska Molenkamp, Amanda B. Spurdle, Lene Juel Rasmussen
Publikováno v:
Genetics in Medicine
Genetics in Medicine, 21(7), 1486-1496. Nature Publishing Group
Genet Med
Genetics in Medicine, 21(7), 1486-1496. NATURE PUBLISHING GROUP
Genetics in Medicine, 21(7), 1486-1496. Nature Publishing Group
Genet Med
Genetics in Medicine, 21(7), 1486-1496. NATURE PUBLISHING GROUP
PURPOSE:To enhance classification of variants of uncertain significance (VUS) in the DNA mismatch repair (MMR) genes in the cancer predisposition Lynch syndrome, we developed the cell-free in vitro MMR activity (CIMRA) assay. Here, we calibrate and v
Autor:
Rudi G. J. Westendorp, Marie Krogh Nielsen, Guido Keijzers, Torben Lykke Sørensen, Morten Scheibye-Knudsen, Maarten Pieter Rozing, Christopher Rue Molbech, Lene Juel Rasmussen, Jon Ambæk Durhuus
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports
Durhuus, J A, Rozing, M P, Nielsen, M K, Molbech, C R, Keijzers, G, Scheibye-Knudsen, M, Rasmussen, L J, Westendorp, R G J & Sørensen, T L 2021, ' EX-vivo whole blood stimulation with A2E does not elicit an inflammatory cytokine response in patients with age-related macular degeneration ', Scientific Reports, vol. 11, no. 1, 8226 . https://doi.org/10.1038/s41598-021-87337-1
Scientific Reports
Durhuus, J A, Rozing, M P, Nielsen, M K, Molbech, C R, Keijzers, G, Scheibye-Knudsen, M, Rasmussen, L J, Westendorp, R G J & Sørensen, T L 2021, ' EX-vivo whole blood stimulation with A2E does not elicit an inflammatory cytokine response in patients with age-related macular degeneration ', Scientific Reports, vol. 11, no. 1, 8226 . https://doi.org/10.1038/s41598-021-87337-1
Age-related macular degeneration (AMD) is a highly prevalent degenerative disease and a leading cause of vision loss worldwide. Evidence for an inflammatory component in the development of AMD exists, yet the exact mechanisms remain unclear. Bisretin