The NF-κB Pharmacopeia: Novel Strategies to Subdue an Intractable Target

Autor: Daniela Verzella, Jessica Cornice, Paola Arboretto, Davide Vecchiotti, Mauro Di Vito Nolfi, Daria Capece, Francesca Zazzeroni, Guido Franzoso

Publikováno v: Biomedicines, Vol 10, Iss 9, p 2233 (2022)

NF-κB transcription factors are major drivers of tumor initiation and progression. NF-κB signaling is constitutively activated by genetic alterations or environmental signals in many human cancers, where it contributes to almost all hallmarks of ma

Externí odkaz: https://doaj.org/article/7e5eaff61d704563be5a56672d26381b

Insights into the Interaction Mechanism of DTP3 with MKK7 by Using STD-NMR and Computational Approaches

Autor: Annamaria Sandomenico, Lorenzo Di Rienzo, Luisa Calvanese, Emanuela Iaccarino, Gabriella D’Auria, Lucia Falcigno, Angela Chambery, Rosita Russo, Guido Franzoso, Laura Tornatore, Marco D’Abramo, Menotti Ruvo, Edoardo Milanetti, Domenico Raimondo

Publikováno v: Biomedicines, Vol 9, Iss 1, p 20 (2020)

GADD45β/MKK7 complex is a non-redundant, cancer cell-restricted survival module downstream of the NF-kB survival pathway, and it has a pathogenically critical role in multiple myeloma, an incurable malignancy of plasma cells. The first-in-class GADD

Externí odkaz: https://doaj.org/article/830a5a16f29844b08bd60fdf714a01ec

Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity

Autor: Federica Begalli, Jason Bennett, Daria Capece, Daniela Verzella, Daniel D’Andrea, Laura Tornatore, Guido Franzoso

Publikováno v: Biomedicines, Vol 5, Iss 3, p 50 (2017)

Transcription factors of the nuclear factor κB (NF-κB) family are central coordinating regulators of the host defence responses to stress, injury and infection. Aberrant NF-κB activation also contributes to the pathogenesis of some of the most com

Externí odkaz: https://doaj.org/article/8fb9fd9b63dc4f7fbb9ee18db5d15d31

Supplementary information from GADD45β Loss Ablates Innate Immunosuppression in Cancer

Autor: Guido Franzoso, Francesca Zazzeroni, Edoardo Alesse, Antonio Sica, Stuart J. Forbes, Toby Lawrence, Salvatore Papa, Laura Tornatore, Federica Begalli, Marcella De Maglie, Barbara Di Francesco, Daniel D'Andrea, Davide Vecchiotti, Daria Capece, Fabio Pasqualini, Camilla Recordati, Anil K. Thotakura, Mariafausta Fischietti, Jason Bennett, Daniela Verzella

Supplemental Figure Legends and Supplementary Materials and Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4f01ba137904ec86b58c77c7d10618
https://doi.org/10.1158/0008-5472.22412108

Measurement of the Nuclear Modification Factor and Prompt Charged Particle Production in p -Pb and pp Collisions at sNN=5 TeV

Autor: Imanol Corredoira, Barak Raimond Gruberg Cazon, Tommaso Pajero, Oliver Lantwin, Patrick Koppenburg, Alessandro Minotti, Joao Coelho, Aleksandr Solovev, Lesya Shchutska, Sheldon Stone, Niladribihari Sahoo, Alexandre Brea Rodríguez, Guido Franzoso, Jana Crkovska, Eluned Smith, Marina Artuso, Maurizio Martinelli, Olaf Steinkamp, Cristina Sánchez Gras, Agnieszka Oblakowska-Mucha, Vladimir Chulikov, Ivan Belyaev, Gary Robertson, Marcos Romero Lamas, Victor Egorychev, Konrad Klimaszewski, Artur Ukleja, Michela Garau, Elena Graverini, Mariusz Witek, Federico Betti, Ming Zeng, Carina Trippl, Alexandru Tudor Grecu, Patrick Haworth Owen, Michał Mazurek, MATTEO BARTOLINI, Alexander Bitadze, Sergey Filippov, Olivier Schneider, Jinlin Fu, Matteo Giovannetti, Paula Alvarez Cartelle, Christopher John Parkinson, Matthew Kenzie, Kristof De Bruyn, Zhenwei Yang, Pablo Vázquez Regueiro, George Lovell, Nigel Watson, Victor Coco, Alexander Vagner, Anton Poluektov, Christoph Frei, Murilo Rangel, Mick Mulder, Davide Zuliani, Vitalii Lisovskyi, Giovanni Punzi, Fernando Martinez Vidal, Claudio Gotti, Hengne Li, Abraham Antonio Gallas Torreira, Marek Idzik, Andrii Usachov, David Hutchcroft, Efrén Rodríguez Rodríguez, Felipe García, Frédéric Blanc, Igor Slazyk, Michael Wilkinson, Youhua Yang, Mark Tobin, Eduardo Rodrigues, Martino Borsato, Alexander Bondar, Thomas Latham, Claudia Patrignani, Tara Shears, Tomasz Fiutowski, Mark Williams, Giulia Tuci, Miriam Calvo Gomez, Lucas Meyer Garcia, Miroslaw Firlej, Xabier Cid Vidal, S Gomez, Holger Stevens, Luis Miguel Garcia Martin, Tomasz Szumlak, Guido Haefeli, Dorothea Vom Bruch, Ina Carli, Méril Reboud, Ulrik Egede, Alessandro Bertolin, Igor Gorelov, Jakub Moron, Bartłomiej Rachwał, Michael Schmelling, Federico Redi, Oliver Lupton, Lingyun Dai, Saverio Mariani, Kimberley Keri Vos, Jacco De Vries, Igor Kostiuk, Lakshan Ram Madhan Mohan, Andrea Merli, Paul Soler, Sevda Esen, George Lafferty, Zehua Xu, Davide Brundu, Serena Maccolini, Konstantin Belous, Dominik Stefan Mitzel, Maciej Majewski, Pawel Kopciewicz, Gerco Onderwater, Mara Soares, Felipe Luan Souza de Almeida, Alexander Inglessi, Sergey Gromov, Lorenzo Capriotti, Olivier Deschamps, Eleonora Luppi, Wojciech Krzemien, Srishti Bhasin, Simone Bifani, Giovanni Cavallero, Tadeusz Lesiak, Maria Vieites Diaz, Jakub Malczewski, Suzanne Klaver, Daniel Craik, Laurent Dufour, Arantza Oyanguren, Naomi Cooke, Stefano Perazzini, Juan José Saborido Silva, Mauro Piccini, Wojciech Krupa, Raul Iraq Rabadan Trejo

Publikováno v: Physical Review Letters. 128

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::632eea2cf147696ad0256e3df3248c42
https://doi.org/10.1103/physrevlett.128.142004