Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Guido Franceschini"'
Autor:
Massimiliano Ruscica, Margherita Botta, Nicola Ferri, Eleonora Giorgio, Chiara Macchi, Guido Franceschini, Paolo Magni, Laura Calabresi, Monica Gomaraschi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Recent evidence suggests that oxidative stress can play a role in the pathogenesis and the progression of prostate cancer (PCa). Reactive oxygen species (ROS) generation is higher in PCa cells compared to normal prostate epithelial cells and
Externí odkaz:
https://doaj.org/article/236f961aaeed4316833c7b6131b30204
Autor:
Monica Gomaraschi, Alice Ossoli, Samuela Castelnuovo, Sara Simonelli, Chiara Pavanello, Gloria Balzarotti, Marcello Arca, Alessia Di Costanzo, Tiziana Sampietro, Gaetano Vaudo, Damiano Baldassarre, Fabrizio Veglia, Guido Franceschini, Laura Calabresi
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 994-1001 (2017)
The aim of this study was to evaluate the vasoprotective effects of HDL isolated from carriers of LCAT deficiency, which are characterized by a selective depletion of LpA-I:A-II particles and predominance of preβ migrating HDL. HDLs were isolated fr
Externí odkaz:
https://doaj.org/article/7a34f0f2a30043a1ae83e0c728243ac8
Autor:
Alice Ossoli, Edward B Neufeld, Seth G Thacker, Boris Vaisman, Milton Pryor, Lita A Freeman, Christine A Brantner, Irina Baranova, Nicolás O Francone, Stephen J Demosky, Cecilia Vitali, Monica Locatelli, Mauro Abbate, Carlamaria Zoja, Guido Franceschini, Laura Calabresi, Alan T Remaley
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0150083 (2016)
Human familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is characterized by low HDL, accumulation of an abnormal cholesterol-rich multilamellar particle called lipoprotein-X (LpX) in plasma, and renal disease. The aim of our study
Externí odkaz:
https://doaj.org/article/924d5b398dcb4f228c32af616b5ce081
Autor:
Laura Calabresi, Damiano Baldassarre, Sara Simonelli, Monica Gomaraschi, Mauro Amato, Samuela Castelnuovo, Beatrice Frigerio, Alessio Ravani, Daniela Sansaro, Jussi Kauhanen, Rainer Rauramaa, Ulf de Faire, Anders Hamsten, Andries J. Smit, Elmo Mannarino, Steve E. Humphries, Philippe Giral, Fabrizio Veglia, Cesare R. Sirtori, Guido Franceschini, Elena Tremoli
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 8, Pp 1569-1574 (2011)
Lecithin:cholesterol acyltransferase (LCAT) is the enzyme responsible for cholesterol esterification in plasma. LCAT is a major factor in HDL remodeling and metabolism, and it has long been believed to play a critical role in macrophage reverse chole
Externí odkaz:
https://doaj.org/article/d90abf61c6be4a1189cb4e9d0f3290c9
Autor:
Ilaria Zanotti, Francesco Potì, Matteo Pedrelli, Elda Favari, Elsa Moleri, Guido Franceschini, Laura Calabresi, Franco Bernini
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 5, Pp 954-960 (2008)
The liver X receptors (LXRs) have been shown to affect lipoprotein plasma profile, lipid metabolism, and reverse cholesterol transport (RCT). In the present study, we investigated whether a short-term administration of the synthetic LXR agonist T0901
Externí odkaz:
https://doaj.org/article/090850e84bb2480896222c85ef8761bf
Autor:
Bela F. Asztalos, Ernst J. Schaefer, Katalin V. Horvath, Shizuya Yamashita, Michael Miller, Guido Franceschini, Laura Calabresi
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 3, Pp 592-599 (2007)
To better understand the role of LCAT in HDL metabolism, we compared HDL subpopulations in subjects with homozygous (n = 11) and heterozygous (n = 11) LCAT deficiency with controls (n = 22). Distribution and concentrations of apolipoprotein A-I (apoA
Externí odkaz:
https://doaj.org/article/644c994ee6684cc08609d720fd3134d7
Autor:
Miriam Lee, Petri T. Kovanen, Gabriella Tedeschi, Emanuela Oungre, Guido Franceschini, Laura Calabresi
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 3, Pp 539-546 (2003)
Mast cell chymase, a chymotrypsin-like neutral protease, can proteolyze HDL3. Here we studied the ability of rat and human chymase to proteolyze discoidal preβ-migrating reconstituted HDL particles (rHDLs) containing either apolipoprotein A-I (apoA-
Externí odkaz:
https://doaj.org/article/1d1c1f58e42946248767ed4b882d5366
Autor:
Monica Gomaraschi, Alice Ossoli, Silvia Pozzi, Peter Nilsson, Angelo B Cefalù, Maurizio Averna, Jan Albert Kuivenhoven, G Kees Hovingh, Fabrizio Veglia, Guido Franceschini, Laura Calabresi
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95925 (2014)
Mutations in the CETP gene resulting in defective CETP activity have been shown to cause remarkable elevations of plasma HDL-C levels, with the accumulation in plasma of large, buoyant HDL particles enriched in apolipoprotein E. Genetic CETP deficien
Externí odkaz:
https://doaj.org/article/bec15a00ecd6475394964fdbeab21250
Autor:
Cristina Sensi, Sara Simonelli, Ilaria Zanotti, Gabriella Tedeschi, Giulia Lusardi, Guido Franceschini, Laura Calabresi, Ivano Eberini
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95044 (2014)
LCAT (lecithin:cholesterol acyltransferase) catalyzes the transacylation of a fatty acid of lecithin to cholesterol, generating a cholesteryl ester and lysolecithin. The knowledge of LCAT atomic structure and the identification of the amino acids rel
Externí odkaz:
https://doaj.org/article/d992e99ad9c347fca6088e6f66e619e2
Autor:
Laura Calabresi, Gabriella Tedeschi, Chiara Treu, Severino Ronchi, Debora Galbiati, Silvia Airoldi, Cesare R. Sirtori, Yves Marcel, Guido Franceschini
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 6, Pp 935-942 (2001)
The apolipoprotein A-IMilano (apoA-IM) is a molecular variant of apoA-I characterized by the Arg173“→Cys substitution, leading to the formation of homodimers A-IM/A-IM. Upon interaction with palmitoyloleoylphosphatidylcholine, A-IM/A-IM forms onl
Externí odkaz:
https://doaj.org/article/21b7ecc67f204e34bdd1fb3a5b82d4a5