Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Guido Bottà"'
Autor:
Giuliano Meyer, Laura Fugazzola, Paolo Beck-Peccoz, Markus Paulmichl, Charity Nofziger, Elisabetta Salvioni, Elisabeth Grabmayer, Simona Rodighiero, Marta Boccazzi, Guido Bottà, Valeria Vezzoli, Silvia Dossena
Publikováno v:
Journal of Molecular Endocrinology. 43:93-103
Pendred syndrome (PS) is the most frequent form of genetically related syndromic hearing loss, and is associated with mutations of pendrin, encoded by the SLC26A4 gene. This protein localizes to the cellular membrane and permits the exchange of anion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1817c6b122e98f4d13c2f8dbae734f5a
https://doi.org/10.1677/jme-08-0175
https://doi.org/10.1677/jme-08-0175
Autor:
Sabine Schmidt, Guido Bottà, Markus Paulmichl, Ivano Costa, Martin Jakab, Andrea Ravasio, Markus Ritter, Johannes Fürst
Publikováno v:
Cellular Physiology and Biochemistry. 23:397-406
ICln is a ubiquitously expressed multifunctional protein that plays a critical role in regulatory volume decrease after cell swelling. The majority of ICln is localized in the cytosol and a small fraction of ICln associates with the plasma membrane.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::565d8533b269d4919a114281ea6467e0
https://doi.org/10.1159/000218186
https://doi.org/10.1159/000218186
Autor:
Felipe Moreno, Charity Nofziger, Alejandra Pera, Giuliano Meyer, Marta Gandía, Simona Rodighiero, Concepción Hernández-Chico, Guido Bottà, Silvia Dossena, Markus Paulmichl
Publikováno v:
Proceedings of the National Academy of Sciences. 105:18608-18613
Pendred syndrome is an autosomal recessive disorder characterized by sensorineural hearing loss, with malformations of the inner ear, ranging from enlarged vestibular aqueduct (EVA) to Mondini malformation, and deficient iodide organification in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a78791e69e7c2ffbb64c4507d8eab9f
https://doi.org/10.1073/pnas.0805831105
https://doi.org/10.1073/pnas.0805831105
Autor:
Michela Bagnasco, Guido Bottà, Anna Mondini, Elena Bononi, Massimo Conese, Silvia Dossena, Luigi Lanata, Claudia Bazzini, Giuliano Meyer, Markus Paulmichl, Maria Lisa Garavaglia, Rossella Balsamo
Publikováno v:
Cellular Physiology and Biochemistry. 22:455-464
The mucoactive drug S-carbocysteine lysine salt monohydrate (S-CMC-Lys) stimulates glutathione (GSH) efflux from respiratory cells. Since GSH is one of the most important redox regulatory mechanisms, the aim of this study was to evaluate the S-CMC-Ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9313589a06cd1ce9a83df0e41add9f5a
https://doi.org/10.1159/000185494
https://doi.org/10.1159/000185494
Autor:
Faustina Lalatta, Pierangela Castorina, Simona Rodighiero, Paolo Beck-Peccoz, M. Muzza, Valentina Cirello, Markus Paulmichl, Umberto Ambrosetti, Guido Bottà, Silvia Dossena, Laura Fugazzola
Publikováno v:
European Journal of Endocrinology. 157:331-338
Objective: Pendred syndrome (PS) is characterized by the association of sensorineural hearing loss (SNHL) and a partial iodide organification defect at the thyroid level. It is caused by mutations in the SLC26A4 gene. The encoded transmembrane protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e6f56d65d29a2c04fa36a969ed31c9
https://doi.org/10.1530/eje-07-0263
https://doi.org/10.1530/eje-07-0263
Autor:
Elena Bononi, R. Novellini, M. L. Garavaglia, Fabiana Guizzardi, Andrea Binelli, Giuliano Meyer, Simona Rodighiero, Silvia Dossena, L. Daffonchio, Markus Paulmichl, S. Saino, Guido Bottà, Claudia Bazzini, Massimo Conese
Publikováno v:
Journal of Molecular Medicine. 84:97-107
Glutathione (GSH) is one of the most important defense mechanisms against oxidative stress in the respiratory epithelial lining fluid. Considering that GSH secretion in respiratory cells has been postulated to be at least partially electrogenic, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61023387d1ff49170aec1acc4265672d
https://doi.org/10.1007/s00109-005-0720-y
https://doi.org/10.1007/s00109-005-0720-y
Autor:
Ben C. Tilly, Martin Jakab, Markus Ritter, Robert Konrat, Rosaria Gandini, Johannes Fürst, Claudia Bazzini, Giuliano Meyer, Markus Paulmichl, S. Saino, Maria Lisa Garavaglia, Andreas Schedlbauer, Martin Gschwentner, Guido Bottà, Bettina Sarg, Georg Kontaxis, Herbert Lindner
Publikováno v:
Journal of Biological Chemistry, 280(35), 31276-31282. American Society for Biochemistry and Molecular Biology Inc.
ICln is a multifunctional protein involved in regulatory mechanisms as different as membrane ion transport and RNA splicing. The protein is water-soluble, and during regulatory volume decrease after cell swelling, it is able to migrate from the cytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb32906b2dba66ba5d9e9296f35bac4
https://doi.org/10.1074/jbc.m500541200
https://doi.org/10.1074/jbc.m500541200
Autor:
Piero Portincasa, Giuliano Meyer, Fabiana Guizzardi, Markus Paulmichl, Simona Rodighiero, Guido Bottà, S. Saino, Rosangela Manfredi, M. L. Garavaglia, Giuseppe Calamita, Claudia Bazzini, Chiara Sironi
Publikováno v:
Current Drug Targets - Immune, Endocrine & Metabolic Disorders. 5:143-151
The function of the gallbladder is not only to store bile, but also to concentrate it during the interdigestive phase by means of salt-dependent water reabsorption. On the contrary, secretions of water and salt take place during the digestive phase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8acc211bd259f24f49529384b6834d1
https://doi.org/10.2174/1568008054064805
https://doi.org/10.2174/1568008054064805
Autor:
Johannes Fürst, Silvia Dossena, Giuliano Meyer, Umberto Fascio, Chiara Sironi, Simona Rodighiero, Markus Paulmichl, Markus Ritter, M. L. Garavaglia, Guido Bottà, Andrea Ravasio, Silvia De Biasi, Claudia Bazzini, Valeria Vezzoli
Publikováno v:
Journal of Biological Chemistry. 280:19902-19910
Thiazides, such as hydrochlorothiazide (HCTZ), are used to control blood pressure and to reduce renal calcium excretion. These effects are a result of interactions with the NaCl-cotransporter (NCC). This is demonstrated by the fact that mutations wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee2fd27fee8a5ef4ea0655be0eaec32
https://doi.org/10.1074/jbc.m411961200
https://doi.org/10.1074/jbc.m411961200
Autor:
Valeria Vezzoli, Sabine Chwatal, Andrea Ravasio, Martin Jakab, Markus Ritter, Claudia Bazzini, Silvia Dossena, Johannes Fürst, Sonja Eichmüller, Giuliano Meyer, Brigitte Maier, Florian Lang, Guido Bottà, Giovanna Valenti, Markus Paulmichl
Publikováno v:
Journal of Biological Chemistry. 279:7136-7146
How can a large number of different phenotypes be generated by a limited number of genotypes? Promiscuity between different, structurally related and/or unrelated proteins seems to provide a plausible explanation to this pertinent question. Strategie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::954a63e22bf261995c758ed130387172
https://doi.org/10.1074/jbc.m307347200
https://doi.org/10.1074/jbc.m307347200