Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Guido C. Paesen"'
Autor:
Nathaniel S. Chapman, Ruben J. G. Hulswit, Jonna L. B. Westover, Robert Stass, Guido C. Paesen, Elad Binshtein, Joseph X. Reidy, Taylor B. Engdahl, Laura S. Handal, Alejandra Flores, Brian B. Gowen, Thomas A. Bowden, James E. Crowe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV
Externí odkaz:
https://doaj.org/article/b9951ffe5c244d7b912906b85005d70b
Autor:
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mark Hassall, Jehad Alzahrani, Guido C. Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J. Doores, Neil A. Ranson, Martin Stacey, Mark Page, Nicola J. Rose, Thomas A. Bowden, David J. Rowlands, Nicola J. Stonehouse
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens. Virus-like particles (VLPs) form the basis of two of the most successful licensed vaccin
Externí odkaz:
https://doaj.org/article/b7c301ef9e3a4446bd7a97505024123b
Autor:
Weng M. Ng, Mehmet Sahin, Stefanie A. Krumm, Jeffrey Seow, Antra Zeltina, Karl Harlos, Guido C. Paesen, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTf
Externí odkaz:
https://doaj.org/article/c0526be8772c4f10948cbdf141eb261d
Autor:
Ilona Rissanen, Robert Stass, Stefanie A Krumm, Jeffrey Seow, Ruben JG Hulswit, Guido C Paesen, Jussi Hepojoki, Olli Vapalahti, Åke Lundkvist, Olivier Reynard, Viktor Volchkov, Katie J Doores, Juha T Huiskonen, Thomas A Bowden
Publikováno v:
eLife, Vol 9 (2020)
The intricate lattice of Gn and Gc glycoprotein spike complexes on the hantavirus envelope facilitates host-cell entry and is the primary target of the neutralizing antibody-mediated immune response. Through study of a neutralizing monoclonal antibod
Externí odkaz:
https://doaj.org/article/a811ae9d2ec64aa9a3922c1b8fc9e42d
Publikováno v:
Viruses, Vol 13, Iss 2, p 353 (2021)
The Bunyavirales order accommodates related viruses (bunyaviruses) with segmented, linear, single-stranded, negative- or ambi-sense RNA genomes. Their glycoproteins form capsomeric projections or spikes on the virion surface and play a crucial role i
Externí odkaz:
https://doaj.org/article/a9c4cbd08231441c9d4a9352b8a17e20
Autor:
Max Renner, Mattia Bertinelli, Cédric Leyrat, Guido C Paesen, Laura Freitas Saraiva de Oliveira, Juha T Huiskonen, Jonathan M Grimes
Publikováno v:
eLife, Vol 5 (2016)
Non-segmented, (-)RNA viruses cause serious human diseases. Human metapneumovirus (HMPV), an emerging pathogen of this order of viruses (Mononegavirales) is one of the main causes of respiratory tract illness in children. To help elucidate the assemb
Externí odkaz:
https://doaj.org/article/dedf5f7e90ac41bb82ccfbd2349ba24f
Autor:
Natalie J Kingston, Keith Grehan, Joseph S Snowden, Mark Hassall, Jehad Alzahrani, Guido C Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J Doores, Neil A Ranson, Martin Stacey, Mark Page, Nicola J Rose, Thomas A Bowden, David J Rowlands, Nicola J Stonehouse
Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and to newly emerging pathogens. Virus-like particle (VLP) vaccines form the basis of two of the most successful licensed vacci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0345f2318ac7709ebb7dabbc45162e8e
https://doi.org/10.1101/2022.04.22.489148
https://doi.org/10.1101/2022.04.22.489148
Autor:
Christina Dold, Mariolina Salio, John Frater, Peter Simmonds, Christopher P. Conlon, J Slon-Campos, Z Yin, David I. Stuart, N F Schwabe, Guido C. Paesen, D Dong, Richard J. Cornall, Paul Thomson, T Lockett, Oliver W. Bayfield, U S Rajapaksa, J W Fry, P Supasa, Jonathan M. Grimes, R Levin, Wanwisa Dejnirattisai, Graham S. Ogg, Dannielle Wellington, Openshaw Pjm., Chen Y-L., Hawkins Dedp., P Zhang, Giorgio Napolitani, Tao Dong, J K Baillie, C Liu, Cesar Lopez-Camacho, Paul Sopp, M A Ansari, Alfred A. Antson, Ker D-S., Persephone Borrow, Susanna Dunachie, Andrew J. McMichael, Juthathip Mongkolsapaya, Yanchun Peng, B Wang, T Rostron, Shona C Moore, Lance Turtle, G Liu, T I de Silva, Krishanthi Subramaniam, Jeremy Ratcliff, Ho L-P., Benedikt M. Kessler, G Kerr, Yuguang Zhao, X Yao, Malcolm G Semple, Gavin R. Screaton, Paul Klenerman, Wayne Paes, R Jing, Alexander J. Mentzer, Y Zhang, Philip J. R. Goulder, Eleanor Barnes, Julian C. Knight
Publikováno v:
Nature Immunology
NATURE IMMUNOLOGY
Nat Immunol
NATURE IMMUNOLOGY
Nat Immunol
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f78680cf7c854968fa13a2ef61dd0a2
https://ora.ox.ac.uk/objects/uuid:e5e926ec-b256-4608-9956-84db12d56741
https://ora.ox.ac.uk/objects/uuid:e5e926ec-b256-4608-9956-84db12d56741
Autor:
Aekkachai Tuekprakhon, Thomas S. Walter, Donal T. Skelly, Beibei Wang, Marilda M. Siqueira, Thomas A. Bowden, Miles W. Carroll, David Hall, Derrick W. Crook, Susanna Dunachie, Paola Cristina Resende, Julian C. Knight, David I. Stuart, Cesar Lopez-Camacho, Piyada Supasa, Rubin Hulswit, Tao Dong, Guido C. Paesen, J Slon-Campos, S Bibi, Amy Flaxman, Fernanda Nascimento, Neil G. Paterson, Chang Liu, Sarah C. Gilbert, Juthathip Mongkolsapaya, Mark A. Williams, Alex Pauvolid-Corrêa, Paul Klenerman, Sandra Belij-Rammerstorfer, Helen M. Ginn, Eleanor Barnes, Helen M. E. Duyvesteyn, D. Zhou, Teresa Lambe, Valdinete Alves do Nascimento, Elizabeth A. Clutterbuck, Cristiano Fernandes da Costa, Sue Ann Costa Clemens, M Bittaye, Felipe Gomes Naveca, R Levin, R Nutalai, Yuguang Zhao, Andrew J. Pollard, Elizabeth E. Fry, Wanwisa Dejnirattisai, Jingshan Ren, Alexander J. Mentzer, Gavin R. Screaton, Christina Dold
SummaryTerminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutralizing antibody responses to the virus spike derived from early isolates. However, new strains have emerged with multiple mutations: P.1 from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00d2b37eb132a5eabf182afef4de1e8d
https://doi.org/10.1101/2021.03.12.435194
https://doi.org/10.1101/2021.03.12.435194
Autor:
Derrick W. Crook, Eleanor Barnes, Naomi Coombes, D. Zhou, Jingshan Ren, Duyvesteyn Hme., Bassam Hallis, Alexander J. Mentzer, Christina Dold, Sheila F Lumley, Cesar Lopez-Camacho, Aekkachai Tuekprakhon, Elizabeth E. Fry, Guido C. Paesen, Thomas S. Walter, Donal T. Skelly, Beibei Wang, Helen M. Ginn, David I. Stuart, Chang Liu, Sandra Belij-Rammerstorfer, Julian C. Knight, Susanna Dunachie, Juthathip Mongkolsapaya, S Bibi, Teresa Lambe, Amy Flaxman, Sarah C. Gilbert, P Supasa, Wanwisa Dejnirattisai, Paul Klenerman, M Bittaye, Miles W. Carroll, Tao Dong, Sue Charlton, R Levin, R Nutalai, Yuguang Zhao, William James, Gavin R. Screaton, Kevin R. Bewley, Elizabeth A. Clutterbuck, J Slon-Campos, Andrew J. Pollard
Publikováno v:
Cell
The race to produce vaccines against SARS-CoV-2 began when the first sequence was published, and this forms the basis for vaccines currently deployed globally. Independent lineages of SARS-CoV-2 have recently been reported: UK–B.1.1.7, South Africa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045e5452725516d41aae5b3a8540df38
https://pubmed.ncbi.nlm.nih.gov/33730597
https://pubmed.ncbi.nlm.nih.gov/33730597