Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Guido, Posern"'
Autor:
Richard Böhme, Andreas W. Schmidt, Nico Hesselbarth, Guido Posern, Andrea Sinz, Christian Ihling, Patrick Michl, Helmut Laumen, Jonas Rosendahl
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The dolichyl-diphosphooligosaccharide-protein glycosyltransferase non-catalytic subunit (DDOST) is a key component of the oligosaccharyltransferase complex catalyzing N-linked glycosylation in the endoplasmic reticulum lumen. DDOST is associ
Externí odkaz:
https://doaj.org/article/c5b4d3ce336549b9b9c3ee45ab3fbed2
Autor:
Igor Kovacevic, Paula Henriette Schmidt, Annkatrin Kowalski, Bernd J. Helms, Chris H. A. van de Lest, Alexander Kluttig, Guido Posern
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Elevated concentrations of palmitate in serum of obese individuals can impair endothelial function, contributing to development of cardiovascular disease. Although several molecular mechanisms of palmitate-induced endothelial dysfunction hav
Externí odkaz:
https://doaj.org/article/44ebdf5ee38d495d9485c5017c5c057d
Autor:
Anurag Kumar Singh, Amrita Rai, Anja Weber, Martin Gericke, Klaus-Peter Janssen, Markus Moser, Guido Posern
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-16 (2023)
Abstract The actin-regulated transcription factor MRTF-A represents a central relay in mechanotransduction and controls a subset of SRF-dependent target genes. However, gain-of-function studies in vivo are lacking. Here we characterize a conditional
Externí odkaz:
https://doaj.org/article/ef11d5185015412c903701ddcf0ad2a8
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-13 (2022)
Highlights Formation of mammary acini depends on crosstalk between matrix stiffness and MRTF-A Increased matrix stiffness elevates MRTF-A activity and protrusion formation Protrusion formation of MCF10A-derived and primary murine acini is MRTF-depend
Externí odkaz:
https://doaj.org/article/bb3b020bfe6544e6a967a7b6f523424d
Autor:
Amrita Rai, Anurag K. Singh, Nathalie Bleimling, Guido Posern, Ingrid R. Vetter, Roger S. Goody
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Rep15 is an effector that interacts with the GTPase Rab15. Here, the authors show that Rep15 also interacts with Rab3 paralogs and Rab34, present crystal structures of Rep15:Rab complexes and find that Rep15 depletion in glioblastoma cells decreases
Externí odkaz:
https://doaj.org/article/bc3756c4bd714733bf975e62ee0d8c3f
Autor:
Ekaterina Sidorenko, Maria Sokolova, Antti P. Pennanen, Salla Kyheröinen, Guido Posern, Roland Foisner, Maria K. Vartiainen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Myocardin-related transcription factor A (MRTF-A), a coactivator of serum response factor (SRF), regulates the expression of many cytoskeletal genes in response to cytoplasmic and nuclear actin dynamics. Here we describe a novel mechanism to
Externí odkaz:
https://doaj.org/article/02ab6360286c47dc8cfc463a97d95cc7
miRNA mediated downregulation of cyclase-associated protein 1 (CAP1) is required for myoblast fusion
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Myoblast fusion is essential for the formation, growth, and regeneration of skeletal muscle, but the molecular mechanisms that govern fusion and myofiber formation remain poorly understood. Past studies have shown an important role of the actin cytos
Externí odkaz:
https://doaj.org/article/7477d9b861bc4df1a3e22d000199d828
Autor:
Lisa Wieland, Kristina Engel, Ines Volkmer, Anna Krüger, Guido Posern, Malte E. Kornhuber, Martin S. Staege, Alexander Emmer
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Neuroblastoma (NB) is the commonest solid tumor outside the central nervous system in infancy and childhood with a unique biological heterogeneity. In patients with advanced, metastasizing neuroblastoma, treatment failure and poor prognosis is often
Externí odkaz:
https://doaj.org/article/e413ba26f8764312a2e89a26c6dfe93a
Publikováno v:
Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-14 (2018)
Abstract Background MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-mediated gene expression. The activity of MRTF-A is critically dependent on the dissociation of G-actin from N-terminal RPEL motifs. MRTF-SRF induction oft
Externí odkaz:
https://doaj.org/article/3c542579cb014cc4afb4f24a83de375c
Autor:
Franziska Lea Schümann, Elisabeth Groß, Marcus Bauer, Christian Rohde, Sarah Sandmann, Denis Terziev, Lutz P. Müller, Guido Posern, Andreas Wienke, Falko Fend, Martin-Leo Hansmann, Wolfram Klapper, Andreas Rosenwald, Harald Stein, Martin Dugas, Carsten Müller-Tidow, Claudia Wickenhauser, Mascha Binder, Thomas Weber
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1842 (2021)
T-cell lymphomas are highly heterogeneous and their prognosis is poor under the currently available therapies. Enhancers of zeste homologue 1 and 2 (EZH1/2) are histone H3 lysine-27 trimethyltransferases (H3K27me3). Despite the rapid development of n
Externí odkaz:
https://doaj.org/article/d63e8094f749409c9ef0bd7310d01020