Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei.

Autor: Francisco KR; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: krfranci@ucsd.edu., Monti L; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Yang W; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Park H; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Liu LJ; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Watkins K; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Amarasinghe DK; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Nalli M; Laboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy., Roberto Polaquini C; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University, São José do Rio Preto, SP 15054-000, Brazil., Regasini LO; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University, São José do Rio Preto, SP 15054-000, Brazil., Eduardo Miller Crotti A; Faculty of Philosophy, Sciences, and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14040-900, Brazil., Silvestri R; Laboratory Affiliated with the Institute Pasteur Italy - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy., Guidi Magalhães L; Research Group on Natural Products, Center for Research in Sciences and Technology, University of Franca, Franca, SP 14404-600, Brazil., Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Feb 01; Vol. 81, pp. 129123. Date of Electronic Publication: 2023 Jan 03.

Recent Advances on Mutant p53: Unveiling Novel Oncogenic Roles, Degradation Pathways, and Therapeutic Interventions.

Autor: Cordani, Marco^1,2 (AUTHOR) mcordani@ucm.es, Garufi, Alessia³ (AUTHOR) alessia.garufi@ifo.it, Benedetti, Rossella⁴ (AUTHOR) rossella.benedetti@uniroma1.it, Tafani, Marco⁴ (AUTHOR) marco.tafani@uniroma1.it, Aventaggiato, Michele⁴ (AUTHOR) michele.aventaggiato@uniroma1.it, D'Orazi, Gabriella^3,5 (AUTHOR) mcordani@ucm.es, Cirone, Mara⁴ (AUTHOR) mara.cirone@uniroma1.it

Publikováno v: Biomolecules (2218-273X). Jun2024, Vol. 14 Issue 6, p649. 24p.

In vitro anthelmintic activity of the crude hydroalcoholic extract of Piper cubeba fruits and isolated natural products against gastrointestinal nematodes in sheep.

Autor: de Paula Carlis MS; Departamento de Biologia e Zootecnia, Faculdade de Engenharia de Ilha Solteira, Universidade Estadual Paulista, Rua Monção, 226 - Zona Norte, Ilha Solteira, CEP 15385-000, São Paulo, Brazil., Féboli A; Departamento de Física e Química, Faculdade de Engenharia de Ilha Solteira, Universidade Estadual Paulista, Av Brasil, 56, Centro, Ilha Solteira, CEP 15385-000, São Paulo, Brazil., de Laurentiz AC; Departamento de Biologia e Zootecnia, Faculdade de Engenharia de Ilha Solteira, Universidade Estadual Paulista, Rua Monção, 226 - Zona Norte, Ilha Solteira, CEP 15385-000, São Paulo, Brazil., da Silva Filardi R; Departamento de Biologia e Zootecnia, Faculdade de Engenharia de Ilha Solteira, Universidade Estadual Paulista, Rua Monção, 226 - Zona Norte, Ilha Solteira, CEP 15385-000, São Paulo, Brazil., de Oliveira AHP; Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Av Sales de Oliveira 201, Parque Universitário, Franca, CEP 14404-600, São Paulo, Brazil., Andrade E Silva ML; Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Av Sales de Oliveira 201, Parque Universitário, Franca, CEP 14404-600, São Paulo, Brazil., Dos Anjos LA; Departamento de Biologia e Zootecnia, Faculdade de Engenharia de Ilha Solteira, Universidade Estadual Paulista, Rua Monção, 226 - Zona Norte, Ilha Solteira, CEP 15385-000, São Paulo, Brazil., Guidi Magalhães L; Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Av Sales de Oliveira 201, Parque Universitário, Franca, CEP 14404-600, São Paulo, Brazil., da Silva de Laurentiz R; Departamento de Física e Química, Faculdade de Engenharia de Ilha Solteira, Universidade Estadual Paulista, Av Brasil, 56, Centro, Ilha Solteira, CEP 15385-000, São Paulo, Brazil. Electronic address: rosangela@dfq.feis.unesp.br.

Publikováno v: Veterinary parasitology [Vet Parasitol] 2019 Nov; Vol. 275, pp. 108932. Date of Electronic Publication: 2019 Sep 30.

Targeting p53–MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trials.

Autor: Zhu, Haohao¹ (AUTHOR), Gao, Hui² (AUTHOR), Ji, Yingying¹ (AUTHOR), Zhou, Qin¹ (AUTHOR), Du, Zhiqiang¹ (AUTHOR), Tian, Lin¹ (AUTHOR), Jiang, Ying¹ (AUTHOR) jiangying911010@163.com, Yao, Kun¹ (AUTHOR) mhc2133@163.com, Zhou, Zhenhe¹ (AUTHOR) zhouzh@njmu.edu.cn

Publikováno v: Journal of Hematology & Oncology. 7/13/2022, Vol. 15 Issue 1, p1-23. 23p.

Anthelmintic Activities of Extract and Ellagitannins from Phyllanthus urinaria against Caenorhabditis elegans and Zoonotic or Animal Parasitic Nematodes.

Autor: Jato, Jonathan, Waindok, Patrick, Ngnodandi, François Ngnodandi Belga François, Orman, Emmanuel, Agyare, Christian, Bekoe, Emelia Oppong, Strube, Christina, Hensel, Andreas, Liebau, Eva, Spiegler, Verena

Publikováno v: Planta Medica; Oct2023, Vol. 89 Issue 13, p1215-1228, 14p