Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Guideng Li"'
Publikováno v:
Chinese Medical Journal, Vol 137, Iss 7, Pp 762-775 (2024)
Abstract. The efficacy of adaptive immune responses in cancer treatment relies heavily on the state of the T cells. Upon antigen exposure, T cells undergo metabolic reprogramming, leading to the development of functional effectors or memory populatio
Externí odkaz:
https://doaj.org/article/c32cfccebde44a73bb0cf75c1f108b6d
Autor:
Yuqian Wang, Zhe Wang, Juan Yang, Xiaobo Lei, Yisu Liu, Luke Frankiw, Jianwei Wang, Guideng Li
Publikováno v:
Advanced Science, Vol 11, Iss 13, Pp n/a-n/a (2024)
Abstract Deciphering cellular interactions is essential to both understand the mechanisms underlying a broad range of human diseases, but also to manipulate therapies targeting these diseases. Here, the formation of cell doublets resulting from speci
Externí odkaz:
https://doaj.org/article/f170345bbb53458abc990235c212b4ad
Autor:
Zhe Wang, Jingzhe Shang, Yajing Qiu, Hongcheng Cheng, Mengyuan Tao, Ermei Xie, Xin Pei, Wenhui Li, Lianjun Zhang, Aiping Wu, Guideng Li
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113796- (2024)
Summary: The acidic metabolic byproducts within the tumor microenvironment (TME) hinder T cell effector functions. However, their effects on T cell infiltration remain largely unexplored. Leveraging the comprehensive The Cancer Genome Atlas dataset,
Externí odkaz:
https://doaj.org/article/b3cec24690974f72aec035c07cd60699
Autor:
William Chour, Jongchan Choi, Jingyi Xie, Mary E. Chaffee, Thomas M. Schmitt, Kathryn Finton, Diana C. DeLucia, Alexander M. Xu, Yapeng Su, Daniel G. Chen, Rongyu Zhang, Dan Yuan, Sunga Hong, Alphonsus H. C. Ng, Jonah Z. Butler, Rick A. Edmark, Lesley C. Jones, Kim M. Murray, Songming Peng, Guideng Li, Roland K. Strong, John K. Lee, Jason D. Goldman, Philip D. Greenberg, James R. Heath
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract The discovery and characterization of antigen-specific CD8+ T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers. We adapt single-chain trimer (SCT) technologies into a high throughput
Externí odkaz:
https://doaj.org/article/3bdea162be0a4447904d5af92d6a6730
Autor:
Yapeng Su, Melissa E. Ko, Hanjun Cheng, Ronghui Zhu, Min Xue, Jessica Wang, Jihoon W. Lee, Luke Frankiw, Alexander Xu, Stephanie Wong, Lidia Robert, Kaitlyn Takata, Dan Yuan, Yue Lu, Sui Huang, Antoni Ribas, Raphael Levine, Garry P. Nolan, Wei Wei, Sylvia K. Plevritis, Guideng Li, David Baltimore, James R. Heath
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Detailed understanding of how cancer cells transition from a drug sensitive to a tolerant state is lacking. Here, using single cell proteomic and metabolic data the authors uncover that isogenic BRAF mutant melanoma cells can take two distinct paths
Externí odkaz:
https://doaj.org/article/ef83fd0a40a640fbb4a0b6caefb26789
Autor:
Tonika Lam, Lisa M Thomas, Clayton A White, Guideng Li, Egest J Pone, Zhenming Xu, Paolo Casali
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174195 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0080414.].
Externí odkaz:
https://doaj.org/article/4ef65b824f434301ad4a29087f34294d
Autor:
Guideng Li, Clayton A. White, Tonika Lam, Egest J. Pone, Daniel C. Tran, Ken L. Hayama, Hong Zan, Zhenming Xu, Paolo Casali
Publikováno v:
Cell Reports, Vol 5, Iss 3, Pp 702-714 (2013)
Class-switch DNA recombination (CSR) is central to the antibody response, in that it changes the immunoglobulin heavy chain (IgH) constant region, thereby diversifying biological effector functions of antibodies. The activation-induced cytidine deami
Externí odkaz:
https://doaj.org/article/909f8aded5874483ab5f5fd1ce264d6b
Autor:
Hong Zan, Clayton A. White, Lisa M. Thomas, Thach Mai, Guideng Li, Zhenming Xu, Jinsong Zhang, Paolo Casali
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1220-1232 (2012)
By diversifying the biological effector functions of antibodies, class switch DNA recombination (CSR) plays a critical role in the maturation of the immune response. It is initiated by activation-induced cytidine deaminase (AID)-mediated deoxycytosin
Externí odkaz:
https://doaj.org/article/a9d31f27fc4d4e26adf325b60375be38
Autor:
Tonika Lam, Lisa M Thomas, Clayton A White, Guideng Li, Egest J Pone, Zhenming Xu, Paolo Casali
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80414 (2013)
Class switch DNA recombination (CSR) of the immunoglobulin heavy chain (IgH) locus crucially diversifies antibody biological effector functions. CSR involves the induction of activation-induced cytidine deaminase (AID) expression and AID targeting to
Externí odkaz:
https://doaj.org/article/b3caa5d832f34c3da8f1f39c33e0ebbc
Autor:
Hongcheng Cheng, Yajing Qiu, Yue Xu, Li Chen, Kaili Ma, Mengyuan Tao, Luke Frankiw, Hongli Yin, Ermei Xie, Xiaoli Pan, Jing Du, Zhe Wang, Wenjie Zhu, Lu Chen, Lianjun Zhang, Guideng Li
Publikováno v:
Nature Metabolism. 5:314-330
The accumulation of acidic metabolic waste products within the tumor microenvironment inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains unclear how an acidic environment affects T cell metabolism and differenti