Co-Expression of TIGIT and Helios Marks Immunosenescent CD8 ⁺ T Cells During Aging.

Autor: Pieren DKJ; Centre for Infectious Disease Control, National Institute for Public Health and The Environment, Bilthoven, Netherlands., Smits NAM; Centre for Infectious Disease Control, National Institute for Public Health and The Environment, Bilthoven, Netherlands., Postel RJ; Centre for Infectious Disease Control, National Institute for Public Health and The Environment, Bilthoven, Netherlands., Kandiah V; Centre for Infectious Disease Control, National Institute for Public Health and The Environment, Bilthoven, Netherlands., de Wit J; Centre for Infectious Disease Control, National Institute for Public Health and The Environment, Bilthoven, Netherlands., van Beek J; Centre for Infectious Disease Control, National Institute for Public Health and The Environment, Bilthoven, Netherlands., van Baarle D; Centre for Infectious Disease Control, National Institute for Public Health and The Environment, Bilthoven, Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Guichelaar T; Centre for Infectious Disease Control, National Institute for Public Health and The Environment, Bilthoven, Netherlands.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 May 16; Vol. 13, pp. 833531. Date of Electronic Publication: 2022 May 16 (Print Publication: 2022).

Regulatory KIR ⁺ RA ⁺ T cells accumulate with age and are highly activated during viral respiratory disease.

Autor: Pieren DKJ; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Smits NAM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Hoeboer J; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Kandiah V; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Postel RJ; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Mariman R; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., van Beek J; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., van Baarle D; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., de Wit J; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Guichelaar T; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Publikováno v: Aging cell [Aging Cell] 2021 Jun; Vol. 20 (6), pp. e13372. Date of Electronic Publication: 2021 May 27.

Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness.

Autor: Pieren DKJ; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Smits NAM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Imholz S; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Nagarajah B; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., van Oostrom CT; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Brandt RMC; Department of Molecular Genetics, Erasmus MC, Rotterdam, Netherlands., Vermeij WP; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Dollé MET; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Guichelaar T; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.

Publikováno v: Frontiers in aging [Front Aging] 2021; Vol. 2. Date of Electronic Publication: 2021 May 11.

Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice.

Autor: Schilperoort M; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., van den Berg R; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Bosmans LA; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands., van Os BW; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands., Dollé MET; Centre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Smits NAM; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Guichelaar T; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., van Baarle D; Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Koemans L; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Berbée JFP; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Deboer T; Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden, The Netherlands., Meijer JH; Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden, The Netherlands., de Vries MR; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands., Vreeken D; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.; Division of Nephrology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands., van Gils JM; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.; Division of Nephrology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands., Willems van Dijk K; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., van Kerkhof LWM; Centre for Health Protection, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Lutgens E; Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität, Munich, Germany., Biermasz NR; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Rensen PCN; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands., Kooijman S; Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.

Publikováno v: Journal of pineal research [J Pineal Res] 2020 Jan; Vol. 68 (1), pp. e12614. Date of Electronic Publication: 2019 Oct 10.

Response kinetics reveal novel features of ageing in murine T cells.

Autor: Pieren DKJ; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Smits NAM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., van de Garde MDB; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Guichelaar T; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. teun.guichelaar@rivm.nl.

Publikováno v: Scientific reports [Sci Rep] 2019 Apr 03; Vol. 9 (1), pp. 5587. Date of Electronic Publication: 2019 Apr 03.