Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Guichang Zou"'
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-10 (2021)
Abstract Lipophilic statins which are blood brain barrier (BBB) permeable are speculated to affect the cholesterol synthesis and neural functions in the central nervous system. However, whether these statins can affect cholesterol levels and synaptic
Externí odkaz:
https://doaj.org/article/183bc99e0192451495e8eb5b5d352315
Autor:
Jin Ye, Guichang Zou, Ruichi Zhu, Chao Kong, Chenjian Miao, Mingjie Zhang, Jianchao Li, Wei Xiong, Chao Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The GABARAP protein is known to support the stability of GABAA receptors (GABAARs) in synapses, but the underlying molecular mechanisms remained to be elucidated. Here authors use biochemistry, X-ray crystallography and electrophsyiology and show tha
Externí odkaz:
https://doaj.org/article/7601d2b73eeb4f368fd223c36dd2f3fb
Autor:
Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang, Wei Xiong
Publikováno v:
iScience, Vol 19, Iss , Pp 634-646 (2019)
Summary: Hyperekplexia disease is usually caused by naturally occurring point mutations in glycine receptors (GlyRs). However, the γ-aminobutyric acid type A receptor (GABAAR) seems to be also involved regarding the therapeutic basis for hyperekplex
Externí odkaz:
https://doaj.org/article/e14890b2f1094986864cd6c4f2c680a9
Autor:
Guichang Zou, Xin Zuo, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu, Wei Xiong
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4209-4219.e7 (2020)
Summary: Cannabinoids are reported to rescue cocaine-induced seizures (CISs), a severe complication in cocaine users. However, the molecular targets for cannabinoid therapy of CISs remain unclear. Here, we report that the systemic administration of c
Externí odkaz:
https://doaj.org/article/3ee44fbe8f244cb2811bf91e30aa5396
Autor:
Shijin Xu, Rui Zhang, Guichang Zou, Shiyun Jin, Heyi Luo, Yiwen Hou, Zou Shi, Ru Zhao, Zhenxin Chen, Bin Wang, Chen Chen, Qi Xue, Meiyan Sun, Wei Xiong, Ye Zhang
Myocardial ischemia/reperfusion injury (MIRI), the major pathophysiology of cardiovascular disease, is a crucial therapeutic focus. To date, whether MIRI is centrally mediated and its underlying processing hierarchy remain elusive. We show that the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50e6b3e2ef36d2457c6830464c161d12
https://doi.org/10.21203/rs.3.rs-2678309/v1
https://doi.org/10.21203/rs.3.rs-2678309/v1
Autor:
Guichang Zou, Wei Xiong, Guanghui Liu, Shao Li, Guolin Zhang, Feng Liu, Biao Chen, Jian Li, Zhou Songyang, Yuangui Zhu, Ruijuan Sun, Yong Shen
Publikováno v:
Chinese Science Bulletin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b2a8331f8eca76a29b4cd48a1cac9ee
https://doi.org/10.1360/tb-2023-0023
https://doi.org/10.1360/tb-2023-0023
Autor:
Yiwen Hou, Guichang Zou, Xianglian Wang, Hui Guo, Xiao Ma, Xingyu Cheng, Zhiyong Xie, Xin Zuo, Jing Xia, Huanhuan Mao, Man Yuan, Qi Chen, Peng Cao, Yupeng Yang, Li Zhang, Wei Xiong
Publikováno v:
Science Advances. 9
Opioid analgesic tolerance, a root cause of opioid overdose and misuse, can develop through an associative learning. Despite intensive research, the locus and central pathway subserving the associative opioid analgesic tolerance (AOAT) remains unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25d43a62dfa3a584b4a66df996a6588c
https://doi.org/10.1126/sciadv.abo5627
https://doi.org/10.1126/sciadv.abo5627
Publikováno v:
Journal of Biological Chemistry. :104769
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fdb3a28f5f6599d513f0ed99adbb3d5
https://doi.org/10.1016/j.jbc.2023.104769
https://doi.org/10.1016/j.jbc.2023.104769
Autor:
Mingjie Zhang, Chao Kong, Guichang Zou, Ruichi Zhu, Chenjian Miao, Jin Ye, Chao Wang, Jianchao Li, Wei Xiong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
GABAA receptors (GABAARs) are the primary fast inhibitory ion channels in the central nervous system. Dysfunction of trafficking and localization of GABAARs to cell membranes is clinically associated with severe psychiatric disorders in humans. The G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af065c0131a919638dc776220916c339
https://doaj.org/article/7601d2b73eeb4f368fd223c36dd2f3fb
https://doaj.org/article/7601d2b73eeb4f368fd223c36dd2f3fb
Publikováno v:
Journal of Biological Chemistry. 295:138-145
The functions of the glycine receptor (GlyR) and GABAA receptor (GABAAR) are both impaired in hyperekplexia, a neurological disorder usually caused by GlyR mutations. Although emerging evidence indicates that cannabinoids can directly restore normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1ccaf546dcb3f5301823b5fcc950d08
https://doi.org/10.1074/jbc.ra119.011221
https://doi.org/10.1074/jbc.ra119.011221