Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.

Autor: Kirkman LA; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, NY 10065; lak9015@med.cornell.edu cnathan@med.cornell.edu gal2005@med.cornell.edu.; Department of Microbiology and Immunology, Weill Cornell Medicine, NY 10065., Zhan W; Department of Microbiology and Immunology, Weill Cornell Medicine, NY 10065., Visone J; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, NY 10065., Dziedziech A; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, NY 10065., Singh PK; Chemical Core Facility, Department of Biochemistry, Weill Cornell Medicine, NY 10065., Fan H; Department of Microbiology and Immunology, Weill Cornell Medicine, NY 10065., Tong X; Department of Microbiology and Immunology, Weill Cornell Medicine, NY 10065., Bruzual I; Department of Research and Development, Portland Veterans Affairs Medical Center, Oregon Health and Science University, Portland, OR 97239., Hara R; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065., Kawasaki M; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065., Imaeda T; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065., Okamoto R; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065., Sato K; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065., Michino M; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065., Alvaro EF; Diseases of the Developing World (DDW), Tres Cantos Medicine Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain., Guiang LF; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA 94901., Sanz L; Diseases of the Developing World (DDW), Tres Cantos Medicine Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760, Tres Cantos, Madrid, Spain., Mota DJ; Department of Medicine, University of California, San Francisco, CA 94143., Govindasamy K; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 11201., Wang R; NMR Analytical Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Ling Y; Department of Microbiology and Immunology, Weill Cornell Medicine, NY 10065., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Sukenick G; NMR Analytical Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Shi L; Department of Biophysics, Weill Cornell Medicine, NY 10065., Vendome J; Schrödinger, Inc., New York, NY 10036., Bhanot P; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 11201., Rosenthal PJ; Department of Medicine, University of California, San Francisco, CA 94143., Aso K; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065., Foley MA; Tri-Institutional Therapeutics Discovery Institute, New York, NY 10065., Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA 94901., Kafsack B; Department of Microbiology and Immunology, Weill Cornell Medicine, NY 10065., Doggett JS; Department of Research and Development, Portland Veterans Affairs Medical Center, Oregon Health and Science University, Portland, OR 97239., Nathan CF; Department of Microbiology and Immunology, Weill Cornell Medicine, NY 10065; lak9015@med.cornell.edu cnathan@med.cornell.edu gal2005@med.cornell.edu., Lin G; Department of Microbiology and Immunology, Weill Cornell Medicine, NY 10065; lak9015@med.cornell.edu cnathan@med.cornell.edu gal2005@med.cornell.edu.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 17; Vol. 115 (29), pp. E6863-E6870. Date of Electronic Publication: 2018 Jul 02.