Zobrazeno 1 - 10
of 68
pro vyhledávání: '"GuiHu Zhao"'
Autor:
Shiyu Zhang, Zheng Wang, Yijing Wang, Yixiao Zhu, Qiao Zhou, Xingxing Jian, Guihu Zhao, Jian Qiu, Kun Xia, Beisha Tang, Julian Mutz, Jinchen Li, Bin Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 representative aging-related biomarkers associated with all-cause mortality. W
Externí odkaz:
https://doaj.org/article/c603a664612e43f99fdb8d1fec1514d6
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e35649- (2024)
Background: Smoking is a widespread behavior, while the relationship between smoking and various diseases remains a topic of debate. Objective: We conducted analysis to further examine the identified associations and assess potential causal relations
Externí odkaz:
https://doaj.org/article/f324f286dc97402488e4d86a09225b3e
Autor:
Yuanfeng Huang, Qian Chen, Zheng Wang, Yijing Wang, Aojie Lian, Qiao Zhou, Guihu Zhao, Kun Xia, Beisha Tang, Bin Li, Jinchen Li
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract Substantial evidence shown that the age at onset (AAO) of Parkinson’s disease (PD) is a major determinant of clinical heterogeneity. However, the mechanisms underlying heterogeneity in the AAO remain unclear. To investigate the risk factor
Externí odkaz:
https://doaj.org/article/2ab4e991460f4a9ea0541ae83a60696e
Autor:
Kuokuo Li, Jifang Xiao, Zhengbao Ling, Tengfei Luo, Jingyu Xiong, Qian Chen, Lijie Dong, Yijing Wang, Xiaomeng Wang, Zhaowei Jiang, Lu Xia, Zhen Yu, Rong Hua, Rui Guo, Dongdong Tang, Mingrong Lv, Aojie Lian, Bin Li, GuiHu Zhao, Xiaojin He, Kun Xia, Yunxia Cao, Jinchen Li
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104928- (2024)
Summary: Background: Genomic variants outside of the canonical splicing site (±2) may generate abnormal mRNA splicing, which are defined as non-canonical splicing variants (NCSVs). However, the clinical interpretation of NCSVs in neurodevelopmental
Externí odkaz:
https://doaj.org/article/7a015e54ce934fb6a3f4f6af2d016784
Autor:
Zheng Wang, Guihu Zhao, Bin Li, Zhenghuan Fang, Qian Chen, Xiaomeng Wang, Tengfei Luo, Yijing Wang, Qiao Zhou, Kuokuo Li, Lu Xia, Yi Zhang, Xun Zhou, Hongxu Pan, Yuwen Zhao, Yige Wang, Lin Wang, Jifeng Guo, Beisha Tang, Kun Xia, Jinchen Li
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 3, Pp 649-661 (2023)
Non-coding variants in the human genome significantly influence human traits and complex diseases via their regulation and modification effects. Hence, an increasing number of computational methods are developed to predict the effects of variants in
Externí odkaz:
https://doaj.org/article/2ac6004b32a44c91aa2800ff830cba23
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5218-5225 (2022)
Transcriptomics studies have yielded great insights into disease processes by detecting differentially expressed genes (DEGs). In this study, due to the high heritability of Parkinson’s disease (PD), we performed bioinformatics analyses on nine tra
Externí odkaz:
https://doaj.org/article/cc463477b4d44aa4a8f4187ccf9e27ca
Autor:
Lijie Dong, Yijing Wang, Xiaomeng Wang, Tengfei Luo, Qiao Zhou, Guihu Zhao, Bin Li, Lu Xia, Kun Xia, Jinchen Li
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
BackgroundCommon polygenic risk and de novo variants (DNVs) capture a small proportion of autism spectrum disorder (ASD) liability, and ASD phenotypic heterogeneity remains difficult to explain. Integrating multiple genetic factors contribute to clar
Externí odkaz:
https://doaj.org/article/b4f138f17bba4aadbbb292bef002156c
Autor:
Tengfei Luo, Kuokuo Li, Zhengbao Ling, Guihu Zhao, Bin Li, Zheng Wang, Xiaomeng Wang, Ying Han, Lu Xia, Yi Zhang, Qiao Zhou, Zhenghuan Fang, Yijing Wang, Qian Chen, Xun Zhou, Hongxu Pan, Yuwen Zhao, Yige Wang, Lijie Dong, Yuanfeng Huang, Zhengmao Hu, Qian Pan, Kun Xia, Jinchen Li
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1414-1422 (2021)
Folate deficiency is an environmental risk factor for several developmental disorders. De novo mutations (DNMs) also play important etiological roles in various developmental disorders. However, it remains unclear whether DNMs in folate-related genes
Externí odkaz:
https://doaj.org/article/92cdb209b2234756b381e7dffe3a998f
Autor:
Bin Li, Zheng Wang, Qian Chen, Kuokuo Li, Xiaomeng Wang, Yijing Wang, Qian Zeng, Ying Han, Bin Lu, Yuwen Zhao, Rui Zhang, Li Jiang, Hongxu Pan, Tengfei Luo, Yi Zhang, Zhenghuan Fang, Xuewen Xiao, Xun Zhou, Rui Wang, Lu Zhou, Yige Wang, Zhenhua Yuan, Lu Xia, Jifeng Guo, Beisha Tang, Kun Xia, Guihu Zhao, Jinchen Li
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1603-1611 (2021)
Genotype–phenotype correlations are the basis of precision medicine of human genetic diseases. However, it remains a challenge for clinicians and researchers to conveniently access detailed individual-level clinical phenotypic features of patients
Externí odkaz:
https://doaj.org/article/d776ccf35aa543dab9583e7539073d3c
Autor:
Zhenhua Liu, Guihu Zhao, Yuhui Xiao, Sheng Zeng, Yanchun Yuan, Xun Zhou, Zhenghuan Fang, Runcheng He, Bin Li, Yuwen Zhao, Hongxu Pan, Yige Wang, Guoliang Yu, I-Feng Peng, Depeng Wang, Qingtuan Meng, Qian Xu, Qiying Sun, Xinxiang Yan, Lu Shen, Hong Jiang, Kun Xia, Junling Wang, Jifeng Guo, Fan Liang, Jinchen Li, Beisha Tang
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: Short tandem repeats (STRs) are highly variable elements that play a pivotal role in multiple genetic diseases and the regulation of gene expression. Long-read sequencing (LRS) offers a potential solution to genome-wide STR analysis. Howe
Externí odkaz:
https://doaj.org/article/364ecc92295a4f3ca3c13537829e73ef