Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Gui-bo Sun"'
Autor:
Ting Zhu, Bin-Yu Fang, Xiang-Bao Meng, Shu-Xia Zhang, Hong Wang, Ge Gao, Fei Liu, Yu Wu, Jin Hu, Gui-Bo Sun, Xiao-Bo Sun
Publikováno v:
Pharmaceutical Biology, Vol 60, Iss 1, Pp 195-205 (2022)
Context Folium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) is a compound preparation commonly used for treating cerebral ischaemia/reperfusion injury in ischaemic stroke in China. However, its potential mech
Externí odkaz:
https://doaj.org/article/079e4fa867ed4d2cb87cba593ce6dc30
Autor:
Nan Li, Ying-Xia Xiong, Fan Ye, Bing Jin, Jin-Jia Wu, Miao-Miao Han, Tian Liu, Yi-Kai Fan, Cun-Yu Li, Jiu-Shi Liu, Ying-Hua Zhang, Gui-Bo Sun, Yun Zhang, Zheng-Qi Dong
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 895 (2023)
The activity of polysaccharides is usually related to molecular weight. The molecular weight of polysaccharides is critical to their immunological effect in cancer therapy. Herein, the Codonopsis polysaccharides of different molecular weights were is
Externí odkaz:
https://doaj.org/article/7fbc592567d44aa3b6d3db404e5fb7e2
Autor:
Yu Tian, Shan Wang, Hai Shang, Wen-Qian Wang, Bao-Qi Wang, Xi Zhang, Xu-Dong Xu, Gui-Bo Sun, Xiao-Bo Sun
Publikováno v:
Pharmaceutical Biology, Vol 57, Iss 1, Pp 133-139 (2019)
Context: Calenduloside E (CE), one of the primary natural products found in Aralia elata (Miq.) Seem. (Araliaceae), possesses prominent anti-apoptotic potential. A previous study found that one of the anti-apoptotic CE targets is heat shock protein 9
Externí odkaz:
https://doaj.org/article/db3189fdc83b4c6f846173bbf370c6c2
Publikováno v:
Cellular Physiology and Biochemistry, Vol 41, Iss 5, Pp 1957-1969 (2017)
Background/Aims: This study aimed to investigate whether Salvianolic acid A (Sal A) conferred cardiac protection against Arsenic trioxide (ATO)-induced cardiotoxicity in H9c2 cells by inhibiting MAPK pathways activation. Methods: H9c2 cardiac cells w
Externí odkaz:
https://doaj.org/article/e8d770c9d04c46f490d2f25d9bc86077
Autor:
Zi-Ru Dai, Jing Ning, Gui-Bo Sun, Ping Wang, Feng Zhang, Hong-Ying Ma, Li-Wei Zou, Jie Hou, Jing-Jing Wu, Guang-Bo Ge, Xiao-Bo Sun, Ling Yang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Bufotalin (BFT), one of the naturally occurring bufodienolides, has multiple pharmacological and toxicological effects including antitumor activity and cardiotoxicity. This study aimed to character the metabolic pathway(s) of BFT and to identify the
Externí odkaz:
https://doaj.org/article/eabee42cdb1a406ca7305c2343efafb9
Autor:
Jing-yi Zhang, Min Wang, Rui-ying Wang, Xiao Sun, Yu-yang Du, Jing-xue Ye, Gui-bo Sun, Xiao-bo Sun
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Arsenic trioxide (ATO) is used as a therapeutic agent in the treatment of acute promyelocytic leukemia (APL). The therapeutic use of arsenic is limited due to its severe cardiovascular side effects. The cardio-protective effect of salvianolic acid A
Externí odkaz:
https://doaj.org/article/35ad4fd1922f4891b92c4b58d1fd64ce
Autor:
Shan Wang, Yu Tian, Jing-Yi Zhang, Hui-Bo Xu, Ping Zhou, Min Wang, Sen-Bao Lu, Yun Luo, Gui-Bo Sun, Xu-Dong Xu, Xiao-Bo Sun
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Calenduloside E (CE), a natural triterpenoid compound isolated from Aralia elata, can protect against ox-LDL-induced human umbilical vein endothelial cell (HUVEC) injury in our previous reports. However, the exact targets and mechanisms of CE remain
Externí odkaz:
https://doaj.org/article/e1a7b5722d1b41da87fbf2d92662c869
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Drug targets and modes of action remain two of the biggest challenges in drug development. To address these problems, chemical proteomic approaches have been introduced to profile targets in complex proteomes. Activity-based protein profiling (ABPP)
Externí odkaz:
https://doaj.org/article/51bee885593d40acaaea1bcc85fccdc6
Autor:
Yu Tian, Yu-Yang Du, Hai Shang, Min Wang, Zhong-Hao Sun, Bao-Qi Wang, Di Deng, Shan Wang, Xu-Dong Xu, Gui-Bo Sun, Xiao-Bo Sun
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Modulation of apoptosis is therapeutically effective in cardiomyocytes damage. Calenduloside E (CE), a naturally occurring triterpenoid saponin, is a potent anti-apoptotic agent. However, little is known about its synthetic analogues on the protectiv
Externí odkaz:
https://doaj.org/article/755c973c6930483ea3b58d15fcc8a3bc
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Modulation of oxidative stress is therapeutically effective in ischemia/reperfusion (I/R) injury. Myricitrin, a naturally occurring phenolic compound, is a potent antioxidant. However, little is known about its effect on I/R injury to cardiac myocyte
Externí odkaz:
https://doaj.org/article/cb6b7fa74538482fbfcb02713b5f3229