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Akademický článek

Crizotinib and Doxorubicin Cooperatively Reduces Drug Resistance by Mitigating MDR1 to Increase Hepatocellular Carcinoma Cells Death

Autor: Ming Shao, Run Shi, Zhen-Xing Gao, Shan-Shan Gao, Jing-Feng Li, Huan Li, Shu-Zhong Cui, Wei-Min Hu, Tian-Yun Chen, Gui-Ru Wu, Jie Zhang, Jiang Xu, Man-Sun Sy, Chaoyang Li

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

As the sixth most lethal cancers worldwide, hepatocellular carcinoma (HCC) has been treated with doxorubicin (Dox) for decades. However, chemotherapy resistance, especially for Dox is an even more prominent problem due to its high cardiotoxicity. To

Externí odkaz: https://doaj.org/article/4a314409de54406dab60d72499dc5173

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Pro-Prion is a Membrane Adaptor Protein for E3 Ligase C-Cbl to Ubiquitinate IGF-IR Promoting Melanoma Metastasis

Autor: Huan Li, Jie Zhang, Jing-Ru Ke, Ze Yu, Run Shi, Shan-Shan Gao, Jing-Feng Li, Zhen-Xing Gao, Changshu Ke, Hui-Xia Han, Jiang Xu, Qibin Leng, Gui-Ru Wu, Yingqiu Li, Lin Tao, Xianghui Zhang, Man-Sun Sy, Chaoyang li

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a200784c62bfe0bc0f1a9f59c41d0c9
https://doi.org/10.2139/ssrn.4063233

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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

Autor: Huan Li, Jie Zhang, Jing-Ru Ke, Ze Yu, Run Shi, Shan-Shan Gao, Jing-Feng Li, Zhen-Xing Gao, Chang-Shu Ke, Hui-Xia Han, Jiang Xu, Qibin Leng, Gui-Ru Wu, Yingqiu Li, Lin Tao, Xianghui Zhang, Man-Sun Sy, Chaoyang Li

Publikováno v: Cell Reports. 41:111834

Aberrant activation of receptor tyrosine kinase (RTK) is usually a result of mutation and plays important roles in tumorigenesis. How RTK without mutation affects tumorigenesis remains incompletely understood. Here we show that in human melanomas pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6847115613ea88389436ae8f9f7b46
https://doi.org/10.1016/j.celrep.2022.111834

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Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production

Autor: Man-Sun Sy, Chaoyang Li, Zhen Xing Gao, Jun Wang, Gui Ru Wu, Tian Chen Mu

Publikováno v: The Journal of Biological Chemistry

The expression of normal cellular prion protein (PrP) is required for the pathogenesis of prion diseases. However, the physiological functions of PrP remain ambiguous. Here, we identified PrP as being critical for tumor necrosis factor (TNF) α-trigg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528ce40643e719bd4ba7b7a62ed4671a
https://doi.org/10.1074/jbc.m117.787283

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Akademický článek

Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production.

Autor: Gui-Ru Wu^1,2, Tian-Chen Mu³, Zhen-Xing Gao¹, Jun Wang¹, Man-Sun Sy⁴, Chao-Yang Li^1,5 cyli@wh.iov.cn

Publikováno v: Journal of Biological Chemistry. 11/17/2017, Vol. 292 Issue 46, p18747-18759. 13p.

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