Výsledky vyhledávání

In vivo inhibitory activity of andrographolide derivative ADN-9 against liver cancer and its mechanisms involved in inhibition of tumor angiogenesis

Autor: Zhenji Wang, Zhenwei Wu, Gui-Fu Dai, Yan Guangming, Jiahui Ma, Wei Yang, Wang Yake, Jin Zhao, Yan Zhang, Shang Ning, Jiang Kunkun, Shen Pengpeng, Haiwei Xu, Guan Zhenzhen, Cuiyun Ma, Hu Yangyang

Publikováno v: Toxicology and Applied Pharmacology. 327:1-12

It is well known that liver cancer is a highly aggressive malignancy with poor prognosis. Andrographolide (AD), a major bioactive component of Andrographis paniculata (Burm. F.), is a potential anti-cancer pharmacophore and the synthesis of AD deriva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68675ec23c3d86a2a35d83c587b7a201
https://doi.org/10.1016/j.taap.2017.04.022

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Efficient hydrolysis of corncob residue through cellulolytic enzymes from Trichoderma strain G26 and l -lactic acid preparation with the hydrolysate

Autor: Xiangyun Lei, Yi Zhao, Huan-Fei Liu, Zhao Jin, Wei Yang, Jian Wu, Zhewei Zhao, Gui-Fu Dai, Gao Mingfu, Xing Xing Wang, Cuiyun Ma, Gao Xiaoxue, Fengjuan Wu, Pengyuan Guo, Lulu Xie, Fengwei Zhang

Publikováno v: Bioresource Technology. 193:331-336

To prepare fermentable hydrolysate from corncob residue (CCR), Trichoderma strain G26 was cultured on medium containing CCR for production of cellulolytic enzymes through solid-state fermentation (SSF), resulting in 71.3 IU/g (FPA), 136.2 IU/g (CMCas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afff926930f7223494009fb4ba81e92
https://doi.org/10.1016/j.biortech.2015.06.101

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Production of Cellulase by Aspergillus niger FC-1 and its Application in Hydrolysis of Corncob Residues

Autor: Jian Wu, Fang Xiaomin, Hui Qin Shi, Zhao Jin, Wei Yang, Xiang Yu Tian, Yi Zhao, Lu Lu Xie, Zhe Wei Zhao, Gui Fu Dai, Wu Di

Publikováno v: Advanced Materials Research. :891-896

In this study,the cellulase-producing ability of Aspergillusniger FC-1 through solid-state fermentation (SSF) and characteristics of the cellulase were investigated. The maximum activities of total cellulase (FPase) and endoglucanase (CMCase) were 8.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f1626fa2851d657327e4b54364dd241
https://doi.org/10.4028/www.scientific.net/amr.1120-1121.891

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Synthesis andin VitroAntiviral Activities of [(Dihydrofuran-2-yl)oxy]methyl-phosphonate Nucleosides with 2-Substituted Adenine as Base

Autor: Yingju Liu, Liu-Xi Zhao, Ya-Feng Wang, Fei Liu, Hong-Min Liu, Piet Herdewijn, Gui-Fu Dai, Ruigang Xu, Christophe Pannecouque, Feng-Wu Liu

Publikováno v: Chemistry & Biodiversity. 12:813-822

The synthesis of [(2',5'-dihydrofuran-2-yl)oxy]methyl-phosphonate nucleosides with a 2-substituted adenine base moiety starting from 2-deoxy-3,5-bis-O-(4-methylbenzoyl)-α-L-ribofuranosyl chloride and 2,6-dichloropurine is described. The key step is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229f54109447951d239e989cd3a26daa
https://doi.org/10.1002/cbdv.201400418

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Novel pyrazole fused heterocyclic ligands: Synthesis, characterization, DNA binding/cleavage activity and anti-BVDV activity

Autor: Dandan Wang, Yan-Chun Guo, Chao Han, Xing-Jie Dai, Jing-Chao Tao, Gui-Fu Dai, Fengjuan Wu, Huan-Fei Liu

Publikováno v: Chinese Chemical Letters. 26:534-538

A series of novel pyrazole fused heterocyclic derivatives were synthesized via a two-step procedure or a one-pot two step method, and their catalytic DNA cleavage abilities and anti-BVDV activities were also evaluated. The results obtained indicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::727b0a2c53ddb464c43e9026df685308
https://doi.org/10.1016/j.cclet.2015.01.006

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Improved inhibitory activities against tumor-cell migration and invasion by 15-benzylidene substitution derivatives of andrographolide

Autor: Liping Zhu, Haiwei Xu, Jing-Hui Song, Gui-Fu Dai, Hong-Min Liu, Gao Mingfu, Wu Jian, Fengjuan Wu, Yanan Wang, Shan-Shan Nie, Zhenwei Wu, Mengjiao Liu, Wei Han, Dan Zhao

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:6421-6426

In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure–activity relationships were studied. Compared to 1 , compounds 8a – 8d ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466d92fccefacbccb486bc8103f74c3c
https://doi.org/10.1016/j.bmcl.2013.09.049

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Cellulase Production by Submerged Fermentation Using Biological Materials of Corncob Residue with Aspergillus Niger FC-1

Autor: Xiao Yu Deng, Ming Fu Gao, Xin Da Shang, Gui Fu Dai, Fang Xiaomin, Biao Zhang, Jian Wu, Hui Qin Shi, Guang Yue Zhu, Yun Pan Liu, Yu Fei Zhang, Sheng Yao Jiang

Publikováno v: Advanced Materials Research. 648:116-119

In order to improve the cellulase-producing ability, the culture medium components and condition were optimized. The results showed that the cellulase activity in the fermentation broth remarkably increased by using 1% corncob residue combined with 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1891107c4e37c6b9b7960793e2a8c90
https://doi.org/10.4028/www.scientific.net/amr.648.116

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Anti-inflammatory effect of novel andrographolide derivatives through inhibition of NO and PGE2 production

Autor: Liping Zhu, Zhiwen Jiang, Weiyi Li, Gui-Fu Dai, Hong-Min Liu, Jin Zhao, Xiao-Rang Chen, Haiwei Xu, Rui-Jing Dong, Wen-Yan Ma

Publikováno v: International Immunopharmacology. 11:2144-2149

Andrographolide (1) is a major diterpene lactone exhibiting anti-inflammatory effects and is found in the plant Andrographis paniculata (Burm. f) Nees, which is widely used in Traditional Chinese Medicine. Synthesis of more effective drugs from andro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95559290ca07da2b6fe2ba4e659be2e
https://doi.org/10.1016/j.intimp.2011.09.010

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Rapid Determination of Pentose and Hexose Sugars in Mixed Sugars by Multiple Linear Regression Calibration Method

Autor: Yong Lei Kou, Biao Zhang, Gui Fu Dai, Ying Long He, Xiao Chen Liu, Jian Wu, Ping Wang

Publikováno v: Applied Mechanics and Materials. 145:159-163

This research provides an improvement for the method of Douglas to determine pentose and hexose sugars in mixed sugars. Specific absorption wave of 553 nm for pentose derivatives and 408 nm for hexose derivatives are selected for determination, and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ee4d9fc7ef4be3f25657589fee24812
https://doi.org/10.4028/www.scientific.net/amm.145.159

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Hydrolysis of Corncob Residue by Enzymes from Fungi C1067 and the Products Analysis by Capillary Electrophoresis

Autor: Xiao Min Fang, Gui Fu Dai, Jian Lu Ma, Huan Fei Liu, Jian Wu, Xin Jiong Guo

Publikováno v: Applied Mechanics and Materials. 145:68-72

To achieve high enzymatic hydrolytic efficiency of corncob residue, one strain, Trichoderma C1067, with the enzyme activity of corncob residue as high as 4.5g/L glucose liberated per hour in 0.5mL crude cellulase and 0.5mL citric acid /sodium citrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbdd4e850fb063fca8332becf2bb0489
https://doi.org/10.4028/www.scientific.net/amm.145.68

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