Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gui-Fang Dou"'
Autor:
Teng Luo, Fei-Xiang Zhang, Ke Zhao, Hui-Ying Gao, Shou-Guo Zhang, Lin Wang, Gui-Fang Dou, Ting Liu, Miao Yu, Yi-Qun Zhan, Hui Chen, Xiao-Ming Yang, Chang-Yan Li
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The compound [3-(1H-benzimidazol-2-methylene)-5-(2-methylphenylaminosulfo)-2-indolone], known as Indo5, is a novel selective inhibitor of c-Met and Trks, and it is a promising anticancer candidate against hepatocellular carcinoma (HCC). Assessing the
Externí odkaz:
https://doaj.org/article/378e2e5e4cf0476aa9a076f4272e65c4
Autor:
Yu-lu Liu, Xiao-xia Zhu, Li-yun Niu, Ya Gao, Hui GAN, Zhuo-na Wu, Jian LI, Su-xiang Feng, Gui-fang Dou, Ruo-lan Gu, Zhi-yun Meng
Publikováno v:
Journal of pharmaceutical sciences.
GEN-0828, a proposed clinical candidate for hemophilia and trauma hemorrhage treatment, is a novel recombinant activated human factor VII (rFVIIa). The purpose of this paper is to compare the pharmacokinetics and pharmacodynamics of GEN-0828 in hemop
Autor:
Shou-Song Tao, Jie Zhang, Wang Yu, Yi-Qun Zhan, Hui Chen, Xiao-Chun Zhang, Miao Yu, Chang-Yan Li, Gui-Fang Dou, Rong-Hua Yin, Guang-Ming Ren, Ya-Ting Li, Xiao-Ming Yang, Wen-Bing Ma, Liu Kai, Ge Changhui, Wen Zhang, Yang Xiao, Xuan-Yi Zhang, Bo-Xue Tian, Jian Li, Ting Wang, Xian Liu
Publikováno v:
Science immunology. 6(58)
Pharmacologically inhibiting nucleotide-binding domain and leucine-rich repeat-containing (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome activation results in potent therapeutic effects in a wide variety of preclinical inflammat
Autor:
Chutse Wu, Gui-Fang Dou, Xiaofang Wang, Yang Yang, Hui Chen, Lihou Dong, Miao Yu, Taoyun Liu, Yue Wan, Zhai Huali
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12886
International Journal of Molecular Sciences, Vol 22, Iss 12886, p 12886 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12886, p 12886 (2021)
International Journal of Molecular Sciences
Acute liver injury shares a common feature of hepatocytes death, immune system disorders, and cellular stress. Hepassocin (HPS) is a hepatokine that has ability to promote hepatocytes proliferation and to protect rats from D-galactose (D-Gal)- or car
Autor:
Heng-Chun Ren, Peng-Fei Tu, Yong Zhou, Gui-Fang Dou, Qin Li, Hong Liang, Qingying Zhang, Ri-Dong Qin, Ling-Yu Li
Publikováno v:
Fitoterapia. 119:100-107
Three new sesquiterpene glycosides (1-3), three new glycerol glycosides (4-6), two new alkaloids (7-8), together with seven known compounds (9-15) all of which were isolated from the genus Pilea for the first time, were isolated from the whole plants
Publikováno v:
Chinese Journal of Cancer Research
Objective This phase I study was to evaluate safety, maximum tolerated dose, pharmacokinetics and preliminary antitumor activity of chidamide, a novel subtype-selective histone deacetylase (HDAC) inhibitor, in combination with paclitaxel and carbopla
Autor:
Mei Dong, Lu Xianping, Ning Zhiqiang, Haixiang Cao, Jia-Lian Xu, Feng-Yi Feng, Puyuan Xing, Gui-Fang Dou, Zhi-Yun Meng, Yuankai Shi
Publikováno v:
Cancer Chemotherapy and Pharmacology. 69:1413-1422
Chidamide (CS055/HBI-8000) is a new benzamide class of histone deacetylase inhibitor with marked anti-tumor activity. This study reports the phase I results. Patients with advanced solid tumors or lymphomas received oral doses of 5, 10, 17.5, 25, 32.
Publikováno v:
Journal of Chromatography B. 852:617-624
A novel HPLC-UV method with pre-column derivatization by using 2-mercaptoethanol was established for determination of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE) in dog plasma. The derivatives were identified by mass spectrometry.
Publikováno v:
Journal of Chromatography B. 850:92-100
The pharmacokinetics (PK) and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine (3,4-DCPB), a novel antiepileptic drug, were investigated after its oral administration to rats (100 mg/kg) by HPLC. The absorption and elimination of 3,4-DCPB w
Autor:
Ying-Yuan Lu, Guo-Liang Zhang, Gui-Fang Dou, Pu Li, Zhi-Yun Meng, Zhong-Jun Li, Xin Wang, Jian Li, Shu-Chun Li, Hong Ren, Chuang Lu, Ya-Qing Lou
Publikováno v:
Scientific Reports
Fructose-based 3-acetyl-2,3-dihydro-1,3,4-oxadiazole (GLB) is a novel antitumor agent and belongs to glycosylated spiro-heterocyclic oxadiazole scaffold derivative. This research first reported a simple, specific, sensitive and stable high performanc