Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gui, Dan Yi"'
Autor:
Lunt, Sophia Y., Muralidhar, Vinayak, Israelsen, William J., Newhouse, Lauren, Ogrodzinski, Martin, Xu, Kali, Hollern, Daniel P., Bellinger, Gary, Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Vander Heiden, Matthew G., Hosios, Aaron Marc, Gui, Dan Yi, Acevedo, Paula N. Marin, Dayton, Talya Lucia, Manalis, Scott R, Yaffe, Michael B, Hecht, Vivian Chaya
Publikováno v:
PMC
Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms on tumor cells has been extensively studied, but whether PKM2 is required for normal cell proliferation is unknown. We examine how PKM2 deletion affects pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fc3381c20adef7d01a1c669923144b
https://pubmed.ncbi.nlm.nih.gov/25482511
https://pubmed.ncbi.nlm.nih.gov/25482511
Akademický článek
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Autor:
Kerry A. Pierce, Gregory Stephanopolous, Dan Y. Gui, Lakshmipriya Subbaraj, Mark A. Keibler, Tyler Jacks, Thales Papagiannakopoulos, Bryan T. Mott, Lucas B. Sullivan, Clary B. Clish, Thomas M. Wasylenko, Matthew G. Vander Heiden, Matthew R. Bauer, Alba Luengo, James P. O’Brien, Abhishek K. Jha, Shawn M. Davidson, Benjamin A. Olenchock, Christopher R. Chin, Julia E. Heyman
Publikováno v:
PMC
Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is less studied. We infused mice with lung cancers with isotope-labeled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de6a0e1b2ca0fee202deb10989c8a59
Publikováno v:
PMC
The role of pyruvate kinase M2 (PKM2) in cell proliferation is controversial. A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the direct activity of this enzyme as a protein kinase; however, a de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7d16bddfcefd5711cf117363e1f3ce
https://doi.org/10.1016/j.molcel.2015.07.013
https://doi.org/10.1016/j.molcel.2015.07.013
Autor:
Nadege Gitego, Aaron M. Hosios, Matthew G. Vander Heiden, Craig J. Thomas, Shawn M. Davidson, Lauren N. Bush, Dan Y. Gui, Alba Luengo, Lucas B. Sullivan, Elizaveta Freinkman
Publikováno v:
PMC
Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. Although metformin can act on cells autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da69b91ec71f501528b53cec4c743571
https://pubmed.ncbi.nlm.nih.gov/27746050
https://pubmed.ncbi.nlm.nih.gov/27746050
Autor:
Dan Y. Gui, Caroline A. Lewis, Seth J. Parker, Adam M. Feist, Courtney R. Green, Natalie I. Vokes, Matthew G. Vander Heiden, Christian M. Metallo, Brian P. Fiske, Douglas McCloskey
Publikováno v:
Molecular cell, vol 55, iss 2
PMC
Lewis, CA; Parker, SJ; Fiske, BP; McCloskey, D; Gui, DY; Green, CR; et al.(2014). Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells. Molecular Cell, 55(2), 253-263. doi: 10.1016/j.molcel.2014.05.008. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6n48402s
PMC
Lewis, CA; Parker, SJ; Fiske, BP; McCloskey, D; Gui, DY; Green, CR; et al.(2014). Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells. Molecular Cell, 55(2), 253-263. doi: 10.1016/j.molcel.2014.05.008. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6n48402s
Eukaryotic cells compartmentalize biochemical processes in different organelles, often relying on metabolic cycles to shuttle reducing equivalents across intracellular membranes. NADPH serves as the electron carrier for the maintenance of redox homeo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fe6d8efa28a71aae400d9a12d346ee
https://escholarship.org/uc/item/6n48402s
https://escholarship.org/uc/item/6n48402s
