Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Guglielmo Bove"'
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-4 (2024)
Abstract Gene expression is an intricate biological process that bridges gap between the genotype and the phenotype. Canonical and hereditable epigenetic mechanisms, such as histone and DNA modifications, regulate the release of genetic information e
Externí odkaz:
https://doaj.org/article/a3c1e332af5f46608acfc61505896699
Autor:
Roberta Pacifico, Nunzio Del Gaudio, Guglielmo Bove, Lucia Altucci, Lydia Siragusa, Gabriele Cruciani, Menotti Ruvo, Rosa Bellavita, Paolo Grieco, Mauro F. A. Adamo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1987-1994 (2022)
We have recently developed a new synthetic methodology that provided both N-aryl-5-hydroxytriazoles and N-pyridine-4-alkyl triazoles. A selection of these products was carried through virtual screening towards targets that are contemporary and valida
Externí odkaz:
https://doaj.org/article/f9c5fcf1b41543b299f0dd8f3efb65c3
Autor:
Nunzio Del Gaudio, Antonella Di Costanzo, Ning Qing Liu, Lidio Conte, Carmela Dell’Aversana, Guglielmo Bove, Rosaria Benedetti, Liliana Montella, Fortunato Ciardiello, Vincenzo Carafa, Concetta Ambrosino, Valeria Tucci, Mariarosaria Conte, Joost H. A. Martens, Hendrik G. Stunnenberg, Angela Nebbioso, Lucia Altucci
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers i
Externí odkaz:
https://doaj.org/article/07529a4a602742c3a53ad8261632a83c
Autor:
Liliana Montella, Nunzio Del Gaudio, Guglielmo Bove, Mariella Cuomo, Michela Buonaiuto, Davide Costabile, Roberta Visconti, Gaetano Facchini, Lucia Altucci, Lorenzo Chiariotti, Rosa Della Monica
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastomas are the most frequent and malignant brain tumor hallmarked by an invariably poor prognosis. They have been classically differentiated into primary isocitrate dehydrogenase 1 or 2 (IDH1 -2) wild-type (wt) glioblastoma (GBM) and secondary
Externí odkaz:
https://doaj.org/article/70f43cceeed8489eac57e87cf301a107
Autor:
Guglielmo, Bove, Sajid, Amin, Mehrad, Babaei, Rosaria, Benedetti, Angela, Nebbioso, Lucia, Altucci, Nunzio, Del Gaudio
Publikováno v:
International journal of cancerREFERENCES.
Chromatin has an extremely flexible structure that allows the fine regulation of gene expression. To orchestrate this process, small chemical modifications are dynamically added or removed on DNA, RNA and histone substrates. Epigenetic modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::927284f0fcefb8d0945b995c9a5135c1
https://pubmed.ncbi.nlm.nih.gov/36444503
https://pubmed.ncbi.nlm.nih.gov/36444503
Autor:
Liliana Montella, Mariella Cuomo, Nunzio Del Gaudio, Michela Buonaiuto, Davide Costabile, Roberta Visconti, Teodolinda Di Risi, Roberta Vinciguerra, Federica Trio, Sara Ferraro, Guglielmo Bove, Gaetano Facchini, Lucia Altucci, Lorenzo Chiariotti, Rosa Della Monica
Publikováno v:
International journal of cancer.
Glioblastoma, the most common and heterogeneous tumor affecting brain parenchyma, is dismally characterized by a very poor prognosis. Thus, the search of new, more effective treatments is a vital need. Here, we will review the druggable epigenetic fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55c00e3c051a72ef4d07e6a06681514
https://pubmed.ncbi.nlm.nih.gov/36479695
https://pubmed.ncbi.nlm.nih.gov/36479695
The OFD1 protein is necessary for the formation of primary cilia and left-right asymmetry establishment but additional functions have also been ascribed to this multitask protein. When mutated, this protein results in a variety of phenotypes ranging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2155e8551680e3d59154df00a0c9f85b
https://hdl.handle.net/11588/879804
https://hdl.handle.net/11588/879804
Autor:
Guglielmo Bove, Sajid Amin, Mehrad Babaei, Rosaria Benedetti, Angela Nebbioso, Lucia Altucci, Nunzio Del Gaudio
Chromatin has an extremely flexible structure that allows the fine regulation of gene expression. To orchestrate this process, small chemical modifications are dynamically added or removed on DNA, RNA, and histone substrates. Epigenetic modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d53fc5dc45c69c139528a1cfccaac9
https://hdl.handle.net/11591/483749
https://hdl.handle.net/11591/483749
Autor:
Margherita Brindisi, Simona Barone, Alice Rossi, Emilia Cassese, Nunzio Del Gaudio, Álvaro Javier Feliz Morel, Gessica Filocamo, Alessia Alberico, Ida De Fino, Davide Gugliandolo, Mehrad Babaei, Guglielmo Bove, Martina Croce, Camilla Montesano, Lucia Altucci, Alessandra Bragonzi, Vincenzo Summa
The latest studies identified the histone deacetylase (HDAC) class of enzymes as strategic components of the complex molecular machinery underlying inflammation in cystic fibrosis (CF). Compelling new support has been provided for HDAC6 isoform as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a7458b7cb2c7d185ed70cf9b9738f7
https://hdl.handle.net/11573/1669487
https://hdl.handle.net/11573/1669487