Evidence of Novel Susceptibility Variants for Prostate Cancer and a Multiancestry Polygenic Risk Score Associated with Aggressive Disease in Men of African Ancestry

Autor: Chen, Fei, Madduri, Ravi K., Rodriguez, Alex A., Darst, Burcu F., Chou, Alisha, Sheng, Xin, Wang, Anqi, Shen, Jiayi, Saunders, Edward J., Rhie, Suhn K., Bensen, Jeannette T., Ingles, Sue A., Kittles, Rick A., Strom, Sara S., Rybicki, Benjamin A., Nemesure, Barbara, Isaacs, William B., Stanford, Janet L., Zheng, Wei, Sanderson, Maureen, John, Esther M., Park, Jong Y., Xu, Jianfeng, Wang, Ying, Berndt, Sonja I., Huff, Chad D., Yeboah, Edward D., Tettey, Yao, Lachance, Joseph, Tang, Wei, Rentsch, Christopher T., Cho, Kelly, Mcmahon, Benjamin H., Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Sellers, Thomas A., Yamoah, Kosj, Murphy, Adam B., Crawford, Dana C., Patel, Alpa V., Bush, William S., Aldrich, Melinda C., Cussenot, Olivier, Petrovics, Gyorgy, Cullen, Jennifer, Neslund-Dudas, Christine M., Stern, Mariana C., Kote-Jarai, Zsofia, Govindasami, Koveela, Cook, Michael B., Chokkalingam, Anand P., Hsing, Ann W., Goodman, Phyllis J., Hoffmann, Thomas J., Drake, Bettina F., Hu, Jennifer J., Keaton, Jacob M., Hellwege, Jacklyn N., Clark, Peter E., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Ogunbiyi, Olufemi, Idowu, Michael O., Popoola, Olufemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Ajibola, Hafees O., Jamda, Mustapha A., Oluwole, Olabode P., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Mensah, James E., Diop, Halimatou, Van Den Eeden, Stephen K., Blanchet, Pascal, Fowke, Jay H., Casey, Graham, Hennis, Anselm J., Lubwama, Alexander, Thompson, Ian M., Jr., Leach, Robin, Easton, Douglas F., Preuss, Michael H., Loos, Ruth J., Gundell, Susan M., Wan, Peggy, Mohler, James L., Fontham, Elizabeth T., Smith, Gary J., Taylor, Jack A., Srivastava, Shiv, Eeles, Rosaline A., Carpten, John D., Kibel, Adam S., Multigner, Luc, Parent, Marie-Élise, Menegaux, Florence, Cancel-Tassin, Geraldine, Klein, Eric A., Andrews, Caroline, Rebbeck, Timothy R., Brureau, Laurent, Ambs, Stefan, Edwards, Todd L., Watya, Stephen, Chanock, Stephen J., Witte, John S., Blot, William J., Michael Gaziano, J., Justice, Amy C., Conti, David V., Haiman, Christopher A.

Publikováno v: In European Urology July 2023 84(1):13-21

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Additional file 2 of Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

Autor: Kim, Michelle S., Naidoo, Daphne, Hazra, Ujani, Quiver, Melanie H., Chen, Wenlong C., Simonti, Corinne N., Kachambwa, Paidamoyo, Harlemon, Maxine, Agalliu, Ilir, Baichoo, Shakuntala, Fernandez, Pedro, Hsing, Ann W., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Diop, Halimatou, Ndoye, Medina, Snyper, Nana Yaa, Adusei, Ben, Mensah, James E., Abrahams, Afua O. D., Biritwum, Richard, Adjei, Andrew A., Adebiyi, Akindele O., Shittu, Olayiwola, Ogunbiyi, Olufemi, Adebayo, Sikiru, Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell M., Ajibola, Hafees O., Oluwole, Olabode P., Jamda, Mustapha A., Singh, Elvira, Pentz, Audrey, Joffe, Maureen, Darst, Burcu F., Conti, David V., Haiman, Christopher A., Spies, Petrus V., van der Merwe, André, Rohan, Thomas E., Jacobson, Judith, Neugut, Alfred I., McBride, Jo, Andrews, Caroline, Petersen, Lindsay N., Rebbeck, Timothy R., Lachance, Joseph

Additional file 2: Table S2. Ability of PRS to distinguish between case and control status using a shared set of variants for both continental datasets.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cda915e9e457ac9090f50a5a61f6f9

Additional file 3 of Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

Autor: Kim, Michelle S., Naidoo, Daphne, Hazra, Ujani, Quiver, Melanie H., Chen, Wenlong C., Simonti, Corinne N., Kachambwa, Paidamoyo, Harlemon, Maxine, Agalliu, Ilir, Baichoo, Shakuntala, Fernandez, Pedro, Hsing, Ann W., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Diop, Halimatou, Ndoye, Medina, Snyper, Nana Yaa, Adusei, Ben, Mensah, James E., Abrahams, Afua O. D., Biritwum, Richard, Adjei, Andrew A., Adebiyi, Akindele O., Shittu, Olayiwola, Ogunbiyi, Olufemi, Adebayo, Sikiru, Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell M., Ajibola, Hafees O., Oluwole, Olabode P., Jamda, Mustapha A., Singh, Elvira, Pentz, Audrey, Joffe, Maureen, Darst, Burcu F., Conti, David V., Haiman, Christopher A., Spies, Petrus V., van der Merwe, André, Rohan, Thomas E., Jacobson, Judith, Neugut, Alfred I., McBride, Jo, Andrews, Caroline, Petersen, Lindsay N., Rebbeck, Timothy R., Lachance, Joseph

Additional file 3: Table S3. Ability of PRS to distinguish between aggressive and non-aggressive forms of CaP using the optimal set of variants for European and African datasets.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5594b15de3a3d8d7a523e22a21681f74

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