Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Guey Ying Liao"'
Publikováno v:
SLAS Discovery, Vol 28, Iss 3, Pp 88-94 (2023)
Deficiencies in brain-derived neurotrophic factor (BDNF) have been linked to several brain disorders, making compounds that can boost neuronal BDNF synthesis attractive as potential therapeutics. However, a sensitive and quantitative BDNF assay for h
Externí odkaz:
https://doaj.org/article/43336eeec251408d93ed97f14568976f
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The TrkB receptor is known to regulate obesity via appetite control, but the underlying neural circuits are not known. Here, the authors show that selective modulation of TrkB+ neurons in the paraventricular hypothalamus regulates food intake via cir
Externí odkaz:
https://doaj.org/article/c3b04a71789a4beeb8932ec97ffd3c5c
Autor:
Zhi-Xiang Xu, Gyu Hyun Kim, Ji-Wei Tan, Anna E. Riso, Ye Sun, Ethan Y. Xu, Guey-Ying Liao, Haifei Xu, Sang-Hoon Lee, Na-Young Do, Chan Hee Lee, Amy E. Clipperton-Allen, Soonwook Kwon, Damon T. Page, Kea Joo Lee, Baoji Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The main cell types involved in autism spectrum disorders through elevated protein synthesis are not well identified. Here, the authors show that overexpression of translation initiation factor eIF4E in microglia results in autism-like behaviour in m
Externí odkaz:
https://doaj.org/article/2eeb7a9bfcc54e13b36e4785832892af
Publikováno v:
Endocrinology
High prevalence of obesity is attributable in part to consumption of highly palatable, fat-rich foods. However, the mechanism controlling dietary fat intake is largely unknown. In this study we investigated the role of brain-derived neurotrophic fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6635329d5cac79892f615d58f0f70e
https://europepmc.org/articles/PMC10205178/
https://europepmc.org/articles/PMC10205178/
Autor:
Guey-Ying Liao, Karine Bouyer, Anna Kamitakahara, Niaz Sahibzada, Chien-Hua Wang, Michael Rutlin, Richard B. Simerly, Baoji Xu
Publikováno v:
Molecular Metabolism, Vol 4, Iss 6, Pp 471-482 (2015)
Objective: Brain-derived neurotrophic factor (BDNF) is a potent regulator of neuronal development, and the Bdnf gene produces two populations of transcripts with either a short or long 3′ untranslated region (3′ UTR). Deficiencies in BDNF signali
Externí odkaz:
https://doaj.org/article/c6487db4ae374db7a9b8dc59a5a518f1
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3256-3261
Genetic evidence indicates that brain-derived neurotrophic factor (BDNF) signaling through the TrkB receptor plays a critical role in the control of energy balance. Mutations in the BDNF or the TrkB-encoding NTRK2 gene have been found to cause severe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c9749ec0aff1d19a85842c3b433c2b
https://doi.org/10.1073/pnas.1815744116
https://doi.org/10.1073/pnas.1815744116
Publikováno v:
Proc Natl Acad Sci U S A
Mutations in the TrkB neurotrophin receptor lead to profound obesity in humans, and expression of TrkB in the dorsomedial hypothalamus (DMH) is critical for maintaining energy homeostasis. However, the functional implications of TrkB-fexpressing neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bb9a4681b2ea4c114ba7479c011f75
https://pubmed.ncbi.nlm.nih.gov/33468645
https://pubmed.ncbi.nlm.nih.gov/33468645
Mutations in the TrkB neurotrophin receptor lead to profound obesity in humans, and expression of TrkB in the dorsomedial hypothalamus (DMH) is critical for maintaining energy homeostasis. However, the functional implications of TrkB-expressing neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f5d0b08978229bde8417f7abbd404d
https://doi.org/10.1101/2020.09.02.279745
https://doi.org/10.1101/2020.09.02.279745
Autor:
Soonwook Kwon, Kea Joo Lee, Sang-Hoon Lee, Amy E. Clipperton-Allen, Ji Wei Tan, Guey Ying Liao, Zhi-Xiang Xu, Chan Hee Lee, Damon T. Page, Baoji Xu, Na Young Do, Haifei Xu, Gyu Hyun Kim, Anna Riso, Ethan Y. Xu, Ye Sun
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Mutations that inactivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly affect males and exhibit social interaction and communication deficits and repetitive behaviors. However, the cells that cause ASD th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e77987005e939257d5d7891cd4ce1db
http://europepmc.org/articles/PMC7156673
http://europepmc.org/articles/PMC7156673
The TrkB receptor is critical for the control of energy balance, as mutations in its gene (NTRK2) lead to hyperphagia and severe obesity in humans and mice. The main neural substrate mediating the appetite-suppressing activity of TrkB, however, remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d2319ab0704f450f13e1601deb0bd6