Distinct cellular mediators drive the Janus faces of toll-like receptor 4 regulation of network excitability which impacts working memory performance after brain injury

Autor: Korgaonkar, Akshata A., Nguyen, Susan, Li, Ying, Sekhar, Dipika, Subramanian, Deepak, Guevarra, Jenieve, Pang, Kevin C.H., Santhakumar, Vijayalakshmi

Publikováno v: In Brain Behavior and Immunity August 2020 88:381-395

Toll-like Receptor 4 Signaling in Neurons Enhances Calcium-Permeable α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Currents and Drives Post-Traumatic Epileptogenesis

Autor: Korgaonkar, Akshata A, Li, Ying, Sekhar, Dipika, Subramanian, Deepak, Guevarra, Jenieve, Swietek, Bogumila, Pallottie, Alexandra, Singh, Sukwinder, Kella, Kruthi, Elkabes, Stella, Santhakumar, Vijayalakshmi

Publikováno v: Annals of neurology, vol 87, iss 4

ObjectiveTraumatic brain injury is a major risk factor for acquired epilepsies, and understanding the mechanisms underlying the early pathophysiology could yield viable therapeutic targets. Growing evidence indicates a role for inflammatory signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::71a66a78a940d990a0874cb26f679c1b
https://escholarship.org/uc/item/0wk4r3tt

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Dendritic morphology and inhibitory regulation distinguish dentate semilunar granule cells from granule cells through distinct stages of postnatal development.

Autor: Gupta A; Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA.; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA., Proddutur A; Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA.; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA., Chang YJ; Office of Advance Research Computing, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Raturi V; Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Guevarra J; Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Shah Y; Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Elgammal FS; Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA., Santhakumar V; Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, 07103, USA. vijayas@ucr.edu.; Department of Molecular, Cell and Systems Biology, University of California, Riverside, CA, 92521, USA. vijayas@ucr.edu.

Publikováno v: Brain structure & function [Brain Struct Funct] 2020 Dec; Vol. 225 (9), pp. 2841-2855. Date of Electronic Publication: 2020 Oct 29.