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Use of a Systems Pharmacology Model Based Approach Toward Dose Optimization of Parathyroid Hormone Therapy in Hypoparathyroidism.

Autor: Khurana M; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland,, USA., Zadezensky I; EMD Serono, Washington, DC, USA., Lowy N; Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland,, USA., Roman D; Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland,, USA., Guettier JM; Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt, Germany., Li L; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland,, USA., Florian J; Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland,, USA., Sahajwalla CG; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland,, USA., Sinha V; Merck & Co, North Wales, Pennsylvania,, USA., Mehrotra N; Merck & Co, North Wales, Pennsylvania,, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2019 Mar; Vol. 105 (3), pp. 710-718. Date of Electronic Publication: 2018 Oct 22.

Joining forces: a call for greater collaboration to study new medicines in children and adolescents with type 2 diabetes.

Autor: Karres J; Paediatric Medicines, European Medicines Agency, London, U.K. janina.karres@ema.europa.eu., Pratt V; Division of Metabolism and Endocrinology Products, U.S. Food and Drug Administration, Silver Spring, MD., Guettier JM; Division of Metabolism and Endocrinology Products, U.S. Food and Drug Administration, Silver Spring, MD., Temeck J; Office of Pediatric Therapeutics, U.S. Food and Drug Administration, Silver Spring, MD., Tamborlane WV; Center for Clinical Investigation, Yale School of Medicine, New Haven, CT., Dunger D; Department of Paediatrics, University of Cambridge, Cambridge, U.K., Bejnariu C; Paediatric Medicines, European Medicines Agency, London, U.K., De Beaufort C; Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Tomasi P; Paediatric Medicines, European Medicines Agency, London, U.K.

Publikováno v: Diabetes care [Diabetes Care] 2014 Oct; Vol. 37 (10), pp. 2665-7.

Chronic activation of a designer G(q)-coupled receptor improves β cell function.

Autor: Jain S; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA., Ruiz de Azua I, Lu H, White MF, Guettier JM, Wess J

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2013 Apr; Vol. 123 (4), pp. 1750-62. Date of Electronic Publication: 2013 Mar 08.

Critical metabolic roles of β-cell M3 muscarinic acetylcholine receptors.

Autor: Ruiz de Azua I; Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, USA., Gautam D, Jain S, Guettier JM, Wess J

Publikováno v: Life sciences [Life Sci] 2012 Nov 27; Vol. 91 (21-22), pp. 986-91. Date of Electronic Publication: 2012 Apr 13.