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Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications.

Autor: Guerrero RF; Department of Biological Sciences, North Carolina State University, Raleigh, United States., Dorji T; Department of Mathematics and Statistics, University of Vermont, Burlington, United States., Harris RM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States., Shoulders MD; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States., Ogbunugafor CB; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States.; Department of Ecology and Evolutionary Biology, Yale University, New Haven, United States.; Santa Fe Institute, Santa Fe, United States.; Public Health Modeling Unit, Yale School of Public Health, New Haven, United States.

Publikováno v: ELife [Elife] 2024 Jun 04; Vol. 12. Date of Electronic Publication: 2024 Jun 04.

Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas.

Autor: Khan RR; Department of Computer Science, Columbia University, New York, NY, USA., Guerrero RF; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.; Department of Computer Science, Indiana University, Bloomington, IN, USA., Wapner RJ; Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA., Hahn MW; Department of Computer Science, Indiana University, Bloomington, IN, USA.; Department of Biology, Indiana University, Bloomington, IN, USA., Raja A; Department of Computer Science, CUNY Hunter College, New York, NY, USA., Salleb-Aouissi A; Department of Computer Science, Columbia University, New York, NY, USA., Grobman WA; Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Simhan H; University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Silver RM; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA., Chung JH; Department of Obstetrics and Gynecology, University of California, Irvine, Orange, CA, USA., Reddy UM; Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA., Radivojac P; Khoury College of Computer Sciences, Northeastern University, Boston, MA, USA., Pe'er I; Department of Computer Science, Columbia University, New York, NY, USA., Haas DM; Indiana University School of Medicine, Indianapolis, IN, 46202, USA. dahaas@iu.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 May 07; Vol. 14 (1), pp. 10514. Date of Electronic Publication: 2024 May 07.

Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b.

Autor: Yan Q; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032, USA., Guerrero RF; Department of Computer Science, Indiana University, Bloomington, IN 47405, USA.; Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA., Khan RR; Department of Computer Science, Columbia University, New York, NY 10032, USA., Surujnarine AA; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032, USA., Wapner RJ; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032, USA., Hahn MW; Department of Computer Science, Indiana University, Bloomington, IN 47405, USA.; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Raja A; Department of Computer Science, CUNY Hunter College, New York, NY 10065, USA., Salleb-Aouissi A; Department of Computer Science, Columbia University, New York, NY 10032, USA., Grobman WA; Department of Obstetrics and Gynecology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Simhan H; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15213, USA., Blue NR; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA., Silver R; Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA., Chung JH; Department of Obstetrics and Gynecology, University of California, Irvine, Orange, CA 92697, USA., Reddy UM; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032, USA., Radivojac P; Khoury College of Computer Sciences, Northeastern University, Boston, MA 02115, USA., Pe'er I; Department of Computer Science, Columbia University, New York, NY 10032, USA., Haas DM; Department of Obstetrics and Gynecology, Indiana University, Indianapolis, IN 46202, USA.

Publikováno v: Genetics [Genetics] 2023 Oct 04; Vol. 225 (2).

Polygenic prediction of preeclampsia and gestational hypertension.

Autor: Honigberg MC; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. mhonigberg@mgh.harvard.edu.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. mhonigberg@mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. mhonigberg@mgh.harvard.edu., Truong B; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Khan RR; Department of Computer Science, Columbia University, New York, NY, USA., Xiao B; University of Pennsylvania, Philadelphia, PA, USA., Bhatta L; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway., Vy HMT; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Guerrero RF; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA., Schuermans A; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Faculty of Medicine, KU Leuven, Leuven, Belgium., Selvaraj MS; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Patel AP; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Koyama S; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cho SMJ; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Integrative Research Center for Cerebrovascular and Cardiovascular Diseases, Seoul, Republic of Korea., Vellarikkal SK; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Trinder M; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada., Urbut SM; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Gray KJ; Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway., Patil S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Zöllner S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Antopia MC; Department of Integrative Biology, University of Texas at San Antonio, San Antonio, TX, USA., Saxena R; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Do R; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yan Q; Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA., Pe'er I; Department of Computer Science, Columbia University, New York, NY, USA., Verma SS; University of Pennsylvania, Philadelphia, PA, USA., Gupta RM; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Haas DM; Indiana University School of Medicine, Indianapolis, IN, USA., Martin HC; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK., van Heel DA; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Laisk T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Natarajan P; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu.

Publikováno v: Nature medicine [Nat Med] 2023 Jun; Vol. 29 (6), pp. 1540-1549. Date of Electronic Publication: 2023 May 29.