Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma

Autor: Zomerman, Walderik W., Plasschaert, Sabine L.A., Conroy, Siobhan, Scherpen, Frank J., Meeuwsen-de Boer, Tiny G.J., Lourens, Harm J., Guerrero Llobet, Sergi, Smit, Marlinde J., Slagter-Menkema, Lorian, Seitz, Annika, Gidding, Corrie E.M., Hulleman, Esther, Wesseling, Pieter, Meijer, Lisethe, van Kempen, Leon C., van den Berg, Anke, Warmerdam, Daniël O., Kruyt, Frank A.E., Foijer, Floris, van Vugt, Marcel A.T.M., den Dunnen, Wilfred F.A., Hoving, Eelco W., Guryev, Victor, de Bont, Eveline S.J.M., Bruggeman, Sophia W.M.

Publikováno v: In Cell Reports 20 March 2018 22(12):3206-3216

Chapter Six - Replication stress: Driver and therapeutic target in genomically instable cancers

Autor: Schoonen, Pepijn M., Guerrero Llobet, Sergi, van Vugt, Marcel A.T.M. ^*

Publikováno v: In Advances in Protein Chemistry and Structural Biology 2019 115:157-201

An mRNA expression-based signature for oncogene-induced replication-stress

Autor: Guerrero Llobet, Sergi, Bhattacharya, Arkajyoti, Everts, Marieke, Kok, Klaas, van der Vegt, Bert, Fehrmann, Rudolf S. N., van Vugt, Marcel A. T. M.

Publikováno v: Oncogene; 20220101, Issue: Preprints p1-9, 9p

The RECQL helicase prevents replication fork collapse during replication stress.

Autor: Benedict B; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., van Bueren MA; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., van Gemert FP; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Lieftink C; Division of Molecular Carcinogenesis, Robotics and Screening Center, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Guerrero Llobet S; Department of Medical Oncology, Cancer Research Center Groningen, University Medical Center Groningen, Groningen, The Netherlands., van Vugt MA; Department of Medical Oncology, Cancer Research Center Groningen, University Medical Center Groningen, Groningen, The Netherlands., Beijersbergen RL; Division of Molecular Carcinogenesis, Robotics and Screening Center, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Te Riele H; Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands h.t.riele@nki.nl.

Publikováno v: Life science alliance [Life Sci Alliance] 2020 Aug 20; Vol. 3 (10). Date of Electronic Publication: 2020 Aug 20 (Print Publication: 2020).

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Autor: Gogola E; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, Amsterdam 1066CX, the Netherlands., Duarte AA; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, Amsterdam 1066CX, the Netherlands., de Ruiter JR; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, Amsterdam 1066CX, the Netherlands., Wiegant WW; Department of Human Genetics, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands., Schmid JA; Institute of Molecular Cancer Research, University of Zurich, Zurich CH-8057, Switzerland., de Bruijn R; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, Amsterdam 1066CX, the Netherlands., James DI; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4BX, UK., Guerrero Llobet S; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen 9723GZ, the Netherlands., Vis DJ; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, Amsterdam 1066CX, the Netherlands., Annunziato S; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, Amsterdam 1066CX, the Netherlands., van den Broek B; Division of Cell Biology and BioImaging Facility, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands., Barazas M; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, Amsterdam 1066CX, the Netherlands., Kersbergen A; Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands., van de Ven M; Mouse Clinic for Cancer and Aging (MCCA), Preclinical Intervention Unit, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands., Tarsounas M; CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK., Ogilvie DJ; Drug Discovery Unit, Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4BX, UK., van Vugt M; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen 9723GZ, the Netherlands., Wessels LFA; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, Amsterdam 1066CX, the Netherlands., Bartkova J; Danish Cancer Society Research Center, Copenhagen 2100, Denmark; Karolinska Institute, Department of Medical Biochemistry and Biophysics, Division of Genome Biology, Science for Life Laboratory, Stockholm 171 77, Sweden., Gromova I; Danish Cancer Society Research Center, Copenhagen 2100, Denmark., Andújar-Sánchez M; Pathology Department, Complejo Hospt. Univ. Insular Materno Infantil, Las Palmas, Gran Canaria, Spain., Bartek J; Danish Cancer Society Research Center, Copenhagen 2100, Denmark; Karolinska Institute, Department of Medical Biochemistry and Biophysics, Division of Genome Biology, Science for Life Laboratory, Stockholm 171 77, Sweden., Lopes M; Institute of Molecular Cancer Research, University of Zurich, Zurich CH-8057, Switzerland., van Attikum H; Department of Human Genetics, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands., Borst P; Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands., Jonkers J; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Cancer Genomics Netherlands, Oncode Institute, Amsterdam 1066CX, the Netherlands. Electronic address: j.jonkers@nki.nl., Rottenberg S; Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam 1066CX, the Netherlands; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern 3012, Switzerland. Electronic address: sven.rottenberg@vetsuisse.unibe.ch.

Publikováno v: Cancer cell [Cancer Cell] 2018 Jun 11; Vol. 33 (6), pp. 1078-1093.e12.