Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Guenther Hochhaus"'
Autor:
Per Bäckman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Ben Forbes, Jayne Hastedt, Anthony Hickey, Guenther Hochhaus, Wenlei Jiang, Stavros Kassinos, Philip J. Kuehl, David Prime, Yoen-Ju Son, Simon P. Teague, Ulrika Tehler, Jennifer Wylie
Publikováno v:
Molecular Pharmaceutics. 19:2040-2047
This work is the second in a series of publications outlining the fundamental principles and proposed design of a biopharmaceutics classifications system for inhaled drugs and drug products (the iBCS). Here, a mechanistic computer-based model has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e43bf5bce93c041df00495ef002eafe
https://doi.org/10.1021/acs.molpharmaceut.2c00112
https://doi.org/10.1021/acs.molpharmaceut.2c00112
Autor:
Jayne E. Hastedt, Per Bäckman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Ben Forbes, Anthony J. Hickey, Guenther Hochhaus, Wenlei Jiang, Stavros Kassinos, Philip J. Kuehl, David Prime, Yoen-Ju Son, Simon Teague, Ulrika Tehler, Jennifer Wylie
Publikováno v:
Molecular Pharmaceutics. 19:2032-2039
For oral drugs, the formulator and discovery chemist have a tool available to them that can be used to navigate the risks associated with the selection and development of immediate release oral drugs and drug products. This tool is the biopharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e324d60f5473a739c5702ca14cbb982f
https://doi.org/10.1021/acs.molpharmaceut.2c00113
https://doi.org/10.1021/acs.molpharmaceut.2c00113
Autor:
Jayne E. Hastedt, Per Bäckman, Andrew R. Clark, William Doub, Anthony Hickey, Guenther Hochhaus, Phil J. Kuehl, Claus-Michael Lehr, Peter Mauser, Jason McConville, Ralph Niven, Masahiro Sakagimi, Jeffry G. Weers
Publikováno v:
AAPS Open, Vol 2, Iss 1, Pp 1-20 (2016)
Abstract The Biopharmaceutics Classification System (BCS), developed in the 1990s for oral immediate release drugs, is utilized by R&D scientists and regulators to streamline product development and regulatory approval timelines. This elegant, scienc
Externí odkaz:
https://doaj.org/article/dc4a2a80e1784e56a752697b1c07da75
Publikováno v:
The Journal of Clinical Pharmacology. 60:1051-1060
Development of effective therapeutics that slow Huntington's disease progression is a research priority that requires an understanding of natural disease progression. We applied a population-modeling approach to describe the progression of 2 routinel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c2e9fb1912564d3261ffb38e18ffdf7
https://doi.org/10.1002/jcph.1598
https://doi.org/10.1002/jcph.1598
Autor:
Andre Hermans, Kailas Thakker, Shirlynn Chen, Margareth Marques, Matthias G. Wacker, Changquan Calvin Sun, Sandra Klein, Sanjaykumar Patel, Tapash Ghosh, Hanlin Li, Justin Yong Soon Tay, Johannes Kraemer, Anne Seidlitz, Sarah Nielsen, Celine Valeria Liew, Przemysław Dorożyński, Christos Reppas, Katharina Pruessmann, Fernando J. Muzzio, Yang Yang, Paul Wan Sia Heng, Guenther Hochhaus, Daniel Willett
Publikováno v:
Dissolution Technologies. 27:52-70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24734d6b4bd6d6fb1be5558496ea2dbd
https://doi.org/10.14227/dt270220p52
https://doi.org/10.14227/dt270220p52
Autor:
Sagar S, Bachhav, Poonam, Sheth, Dennis, Sandell, Mårten, Svensson, Sharvari, Bhagwat, Denise S, Conti, Oluwamurewa, Oguntimein, Sneha, Dhapare, Bhawana, Saluja, Lawrence, Winner, Jürgen B, Bulitta, Guenther, Hochhaus
Publikováno v:
The AAPS Journal. 24
The therapeutic benefits of metered dose inhalers (MDIs) in pulmonary disorders are mainly driven by aerosol performance, which depends on formulation variables (drug and excipients), device design, and patient interactions. The present study provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc30a3b3f9e36e614ba7800318261f0b
https://doi.org/10.1208/s12248-021-00638-1
https://doi.org/10.1208/s12248-021-00638-1
Publikováno v:
Drug Development and Industrial Pharmacy. 45:1101-1110
Peptide YY(3–36) (PYY(3–36)) is an endogenous appetite suppressing peptide. The present research was to perform pharmacokinetic/pharmacodynamic (PK/PD) analysis for predicting the concentration- an...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bafb7d577544ce0f04a6f2942f14aca9
https://doi.org/10.1080/03639045.2019.1593443
https://doi.org/10.1080/03639045.2019.1593443
Autor:
Elham Amini, Per Bäckman, Erica Bäckström, Martyn Biddiscombe, Britta Bonn, Jens Markus Borghardt, Joy Conway, Anne Haaije de Boer, Martin Donnelley, Zachary Enlo-Scott, Ben Forbes, Markus Fridén, Mark Gardner, Anthony J. Hickey, Anneke Himstedt, Guenther Hochhaus, Eric A. Hoffman, Stavros Kassinos, Pantelis Koullapis, Ching-Long Lin, Hans Lundbäck, Kaye Morgan, Bo Olsson, David Parsons, Matthew Perry, Fotos Stylianou, Mårten Svensson, Magda Swedrowska, Josué Sznitman, Kyrre Thalberg, Omar Usmani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3f38ff3881f729112d0edfae6949002
https://doi.org/10.1016/b978-0-12-814974-4.00023-7
https://doi.org/10.1016/b978-0-12-814974-4.00023-7
Autor:
Elham Amini, Guenther Hochhaus
Publikováno v:
Inhaled Medicines ISBN: 9780128149744
The unique physiology of the lungs necessitates special considerations for developing a robust and discriminate dissolution method for orally inhaled drug products (OIDPs). Despite the importance of establishing a bio-relevant in vitro dissolution me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cdcc344ee0c1c536c240a9f147a623a
https://doi.org/10.1016/b978-0-12-814974-4.00008-0
https://doi.org/10.1016/b978-0-12-814974-4.00008-0
Autor:
Jayne E. Hastedt, Per Bäckman, Andrew R. Clark, William Doub, Anthony Hickey, Guenther Hochhaus, Phil J. Kuehl, Claus-Michael Lehr, Peter Mauser, Jason McConville, Ralph Niven, Masahiro Sakagami, Jeffry G. Weers
Publikováno v:
AAPS Open, Vol 2, Iss 1, Pp 1-1 (2016)
Externí odkaz:
https://doaj.org/article/6e5951894e0a4f65983b1feb9e14ab9c