Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Guennadi, Kozlov"'
Autor:
Guennadi Kozlov, Jianning Jiang, Tyler Rutherford, Anne M. Noronha, Christopher J. Wilds, Kalle Gehring
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 764-773 (2024)
La-related proteins (LARPs) are a family of RNA-binding proteins that share a conserved La motif (LaM) domain. LARP1 plays a role in regulating ribosomal protein synthesis and stabilizing mRNAs and has a unique structure without an RNA binding RRM do
Externí odkaz:
https://doaj.org/article/6b6546ccc14b42b59f428ad7279add2a
Autor:
Luba Mahbub, Guennadi Kozlov, Pengyu Zong, Emma L Lee, Sandra Tetteh, Thushara Nethramangalath, Caroline Knorn, Jianning Jiang, Ashkan Shahsavan, Lixia Yue, Loren Runnels, Kalle Gehring
Publikováno v:
eLife, Vol 12 (2023)
Cystathionine-β-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) are an evolutionarily conserved family of magnesium transporters. They promote efflux of Mg2+ ions on their own and influx of divalent cations when expresse
Externí odkaz:
https://doaj.org/article/936846b136cd4ffd8569d36738791439
Autor:
Yu Seby Chen, Guennadi Kozlov, Brandon E. Moeller, Ahmed Rohaim, Rayan Fakih, Benoît Roux, John E. Burke, Kalle Gehring
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CNNM/CorB proteins are a conserved family of membrane proteins associated with Mg2+ transport. Here, structures of an archaeal CorB protein in apo state and with Mg2+-ATP bound and accompanying biophysical experiments suggest direct Mg2+ transport by
Externí odkaz:
https://doaj.org/article/9173b3bf4c7d453b84ee3eb1b8577812
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract The phosphatases of regenerating liver (PRLs) are involved in tumorigenesis and metastatic cancer yet their cellular function remains unclear. Recent reports have shown PRL phosphatases bind tightly to the CNNM family of membrane proteins to
Externí odkaz:
https://doaj.org/article/0fb93675d99f4329802dc664671cbeb7
Autor:
Luba Mahbub, Guennadi Kozlov, Pengyu Zong, Sandra Tetteh, Thushara Nethramangalath, Caroline Knorn, Jianning Jiang, Ashkan Shahsavan, Emma Lee, Lixia Yue, Loren W. Runnels, Kalle Gehring
Cystathionine-β-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) are an evolutionarily conserved family of magnesium transporters. They promote efflux of Mg2+ions on their own or uptake of divalent cations when coupled to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81fadc602a48e6bbe4320cd94e1bb5ee
https://doi.org/10.1101/2023.01.19.524765
https://doi.org/10.1101/2023.01.19.524765
Autor:
Guennadi Kozlov, Sandy Mattijssen, Jianning Jiang, Samuel Nyandwi, Tara Sprules, James R Iben, Steven L Coon, Sergei Gaidamakov, Anne M Noronha, Christopher J Wilds, Richard J Maraia, Kalle Gehring
Publikováno v:
Nucleic acids research. 50(16)
La-related proteins (LARPs) comprise a family of RNA-binding proteins involved in a wide range of posttranscriptional regulatory activities. LARPs share a unique tandem of two RNA-binding domains, La motif (LaM) and RNA recognition motif (RRM), toget
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37717c15758c06e0ab5cdf66c9afe7a9
https://pubmed.ncbi.nlm.nih.gov/35979957
https://pubmed.ncbi.nlm.nih.gov/35979957
Autor:
Kalle Gehring, Edward A. Fon, Véronique Sauvé, George Sung, Guennadi Kozlov, Rayan Fakih, Anshu Saran, Emma J. MacDougall
Publikováno v:
The EMBO Journal. 41
PINK1 and parkin constitute a mitochondrial quality control system mutated in Parkinson’s disease. PINK1, a kinase, phosphorylates ubiquitin to recruit parkin, an E3 ubiquitin ligase, to mitochondria. PINK1 controls both parkin localization and act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3335655f9af76911f597ddd1155e7002
https://doi.org/10.15252/embj.2021109460
https://doi.org/10.15252/embj.2021109460
Autor:
Kalle Gehring, Guennadi Kozlov, Richard J. Maraia, Bruno D. Fonseca, Sergei Gaidamakov, Sandy Mattijssen, Amitabh Ranjan
Publikováno v:
RNA Biol
The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1, LARP1B, LARP3 (La protein), LARP4, LARP4B, LARP6, and LARP7 in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7976e99ad1b46f774f064e2388fc08
https://doi.org/10.1080/15476286.2020.1860376
https://doi.org/10.1080/15476286.2020.1860376
Autor:
Guennadi Kozlov, Kalle Gehring
Publikováno v:
The Febs Journal
The endoplasmic reticulum (ER) is the major folding compartment for secreted and membrane proteins and is the site of a specific chaperone system, the calnexin cycle, for folding N‐glycosylated proteins. Recent structures of components of the calne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106d39a185169d84b5d1be04fabfaffa
http://europepmc.org/articles/PMC7687155
http://europepmc.org/articles/PMC7687155
Autor:
Sharon Kaisari, Shirly Miniowitz-Shemtov, Danielle Sitry-Shevah, Pnina Shomer, Guennadi Kozlov, Kalle Gehring, Avram Hershko
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance The mitotic checkpoint system is essential for the prevention of mistakes in the segregation of chromosomes in mitosis. As long as chromosomes are not attached correctly to the mitotic spindle, a mitotic checkpoint complex (MCC) is assem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092ee69c5a2863319f1f9a797ec450a1
https://doi.org/10.1073/pnas.2121478119
https://doi.org/10.1073/pnas.2121478119