Zobrazeno 1 - 10
of 1 559
pro vyhledávání: '"Guengerich FP"'
Autor:
Guengerich Fp, Parikh A
Publikováno v:
Protein Expression and Purification. 9:346-354
An enzymatically active human cytochrome P450 (P450) 1A2:rat NADPH-P450 reductase fusion protein was purified and partially characterized following heterologous expression inEscherichia coli. A cDNA was engineered to include the coding sequence for h
Publikováno v:
Biochemistry. 35:464-471
Although there are many reports of epoxy alcohol synthesis from lipoxygenase products (fatty acid hydroperoxides) in mammalian tissues, there are no well-defined examples of the stereoselective synthesis of individual epoxy alcohol diastereomers. An
Publikováno v:
Chemical Research in Toxicology. 9:318-325
ESR spin trapping was used to investigate the reaction of rabbit cytochrome P450 (P450) 1A2 with cumene hydroperoxide. Cumene hydroperoxide-derived peroxyl, alkoxyl, and carbon-centered radicals were formed and trapped during the reaction. The relati
Publikováno v:
Biochemistry. 35:2512-2520
Variously substituted alkylanthracenes were studied as models for polycyclic hydrocarbon oxidations. 9-Methylanthracene was oxidized to 9-(hydroxymethyl)anthracene, 10-methyl-10-hydroxy-9-anthrone, and anthraquinone in several systems, including (i)
Publikováno v:
Chirality. 2:150-155
Rates of hydrolysis of racemic and enantiomeric oxazepam 3-acetates (OXA) by esterases in human and rat liver microsomes and rat brain S9 fraction were compared. When rac-OXA was the substrate, esterases in human and rat liver microsomes were highly
Autor:
Guengerich Fp
Publikováno v:
Biological chemistry. 383(10)
Cytochrome P450 (P450) reactions are of interest because of their relevance to the oxidative metabolism of drugs, steroids, carcinogens, and other chemicals. One of the considerations about functional characterization is which steps of the catalytic
Autor:
Guengerich Fp
Publikováno v:
Archives of Biochemistry and Biophysics. 507:1-2
Autor:
Guengerich Fp
Publikováno v:
Chemico-biological interactions. 106(3)
Historically there has been considerable interest in comparing patterns of biotransformation of xenobiotic chemicals in experimental animal models and humans, e.g. in areas such as drug metabolism and chemical carcinogenesis. With the availability of
Autor:
Guengerich Fp
Many adverse drug-drug interactions are attributable to pharmacokinetic problems and can be understood in terms of alterations of P450-catalyzed reactions. Much is now known about the human P450 enzymes and what they do, and it has been possible to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8da01a9b9a1d771c6d1e6fe5c76649a
https://doi.org/10.1016/s1054-3589(08)60200-8
https://doi.org/10.1016/s1054-3589(08)60200-8
Autor:
Guengerich Fp
Publisher Summary The most thoroughly studied of the dihaloalkanes is ethylene dibromide. Considerable evidence now exists to support the view that glutathione (GSH) conjugation is critical to mutagenicity and probably tumorigenesis. The major DNA ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28e8b96b4855bb9f897464d1566e63f7
https://doi.org/10.1016/s1054-3589(08)61034-0
https://doi.org/10.1016/s1054-3589(08)61034-0